Naslov
OVER-DOSE CAFFEINE TOXICITY IN RATS AND TREATMENT WITH STABLE GASTRIC PENTADECAPEPTIDE BPC 157

Autori
Vuković, Vlasta ; Sablić, Marko ; Krezić, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Pharmaca 2022 ; 52 Suppl 2 / Mršić-Pelčić, Jasenka ; Vitezić, Dinko ; Janković, Tamara - Zagreb, 2022, 169-169

Skup
10TH CROATIAN CONGRESS OF PHARMACOLOGY AND THE 1ST CROATIAN CONGRESS OF CLINICAL PHARMACOLOGY WITH INTERNATIONAL PARTICIPATION

Mjesto i datum
Opatija, Hrvatska, 22.09.2022. - 25.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
BPC 157 ; Pentadecapeptide ; Rat

Sažetak
Introduction: Antagonist of adenosine A2A receptors, caffeine, during overdosing, manifests convulsions, arrhythmias, muscle spasms, urination etc. In this study, we administered caffeine to the rats at doses close to LD50 and above LD50 (i.e. LD50 for Wistar rats 367 mg/kg (Adamson RH. Regul Toxicol Pharmacol. 2016 Oct ; 80:274-6. doi: 10.1016/j.yrtph.2016.07.011.)). We observed the effect of stable gastric pentadecapeptide BPC 157 on mitigation of caffeine overdose. Materials and methods: We used male Wistar rats, weighing 250 g. Caffeine was administered in the solution, intraperitoneally (two groups ; the first group - below LD50 (200 mg/kg), the second group - above LD50 (400 mg/kg)). Therapy (BPC 157 (10 ng/kg) or saline (5 ml/kg)) was given intraperitoneally immediately after caffeine. We monitored survival duration of animals, ECG and blood pressures in: inferior caval vein, portal vein, abdominal aorta and superior sagittal sinus as described before (Biomedicines. 2022 ; 10(7):1462). Results: Before fatal outcome, without therapy, caffeine intoxicated rats exhibited severe brain swelling, portal hypertension, caval hypertension, increased intracranial pressure and aortic hypotension and severe supraventricular arrhythmias and extrasystoles, known to be characteristic for the vascular and multiorgan failure-induced occlusion/occlusion like syndromes recently described following major vessel occlusion and alike noxious procedures (Biomedicines. 2022 ; 10(7):1462). These noxious effects were counteracted in the BPC 157 caffeine rats. Conclusions: We found beneficial effects of BPC 157 in the treatment of caffeine overdose.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti

POVEZANOST RADA