Naslov
Dilemmas in the diagnosis and therapy of gestational breast cancer: Review of literature
(Dilemmas in the Diagnosis and Therapy of Gestational Breast Cancer: Review of Literature)

Autori
Fajdic, Josip ; Gotovac, Nikola ; Hrgovic, Zlatko

Izvornik
Tumor Diagnostik und Therapie (0722-219X) 29 (2008), 3; 150-153

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Breast cancer ; Diagnosis ; Management ; Pregnancy

Sažetak
Aim: In spite of the general consensus on the issue, to point to major dilemmas encountered in this entity of multidisciplinary interest, and to review current concepts on how to achieve optimal diagnostic and therapeutic outcome. Results: Recent literature data show the rate of gestational breast cancer according to most protocols to range from 0.2 to 3.8%. By definition, clinical manifestation of this type of carcinoma is expected to occur during pregnancy or within one year of delivery. The mode of treatment and prognosis are identical to those in women with breast carcinoma beyond pregnancy, except for radiotherapy which is not indicated during pregnancy and selective use of cytostatics in polychemotherapy during the first trimester. The only exception to this practice are women with advanced stage of the disease due to delayed diagnosis. Results of large studies indicate that therapy for breast cancer has no adverse effect on the prognosis of subsequent pregnancy. Methods: Recent and older published work available to authors has been reviewed by having in mind common and acceptable methods of treatment used today as well as opinions and data published by more cited authors having in mind institutions with biggest experience in treatment of gestational breast cancer. Public databases and other relevant published literature were used. Conclusion: The evaluation and management of women with gestational breast cancer require a multidisciplinary approach. Chemotherapeutic regimen should be individualized to maximally reduce the risk if administered in the second and third trimester. Surgical therapy may include mastectomy and sparing operative procedures. Sentinel node biopsy should be considered in node negative patients. Radiotherapy should be postponed to the postpartum period.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA