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Gapp G. Steenwyk P. L. Germain W. Matsushima K. L. M. Rudolph F. Manuella M. Roszkowski G. Vernaz T. Ghosh P. Pelczar I. M. Mansuy E. A. Miska Springer US Molecular Psychiatry, doi:10.1038/s41380-018-0271-6 10.1038/s41380-018-0271-6 http://dx.doi.org/10.1038/s41380-018-0271-6 journal Molecular Psychiatry © 2018, The Author(s) 1476-5578 10.1038/s41380-018-0271-6 springer.com springerlink.com 2010-04-23 True 10.1038/s41380-018-0271-6 springer.com springerlink.com Adobe Illustrator CS5.1 2020-04-08T15:58:45+05:30 2020-04-08T15:58:45+05:30 2020-04-08T15:58:45+05:30 True VoR xmp.did:F0E81B155F79EA1192789911B4F9F11E xmp.iid:F0E81B155F79EA1192789911B4F9F11E default 1 uuid:e61e8ba0-e806-4df3-9b0d-c26260ff4735 converted uuid:9e141f34-6983-46e5-91ff-247a7ee60fe2 converted to PDF/A-2b pdfToolbox 2018-11-08T13:20:36+05:30 saved xmp.iid:F0E81B155F79EA1192789911B4F9F11E 2020-04-08T15:58:45+05:30 Adobe Illustrator CS5.1 / uuid:64330ba0-2aaa-467e-83c1-558fac591cac uuid:e61e8ba0-e806-4df3-9b0d-c26260ff4735 uuid:e61e8ba0-e806-4df3-9b0d-c26260ff4735 1 default 2 B 1 False False 210.000274 279.000024 Millimeters Cyan Yellow Default Swatch Group 0 P. L. Germain http://orcid.org/0000-0003-3418-4218 K. L. M. Rudolph http://orcid.org/0000-0002-9866-7051 G. Vernaz http://orcid.org/0000-0001-8942-2370 I. M. Mansuy http://orcid.org/0000-0001-7785-5371 E. A. Miska http://orcid.org/0000-0002-4450-576X http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the name of an author. name Text Gives the ORCID of an author. orcid URI http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text endstream endobj 60 0 obj << /Metadata 61 0 R >> endobj 63 0 obj << /Length 27504 /Subtype /XML /Type /Metadata >> stream application/postscript doi:10.1038/s41380-018-0271-6 Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma K. Gapp G. Steenwyk P. L. Germain W. Matsushima K. L. M. Rudolph F. Manuella M. Roszkowski G. Vernaz T. Ghosh P. Pelczar I. M. Mansuy E. A. Miska Springer US Molecular Psychiatry, doi:10.1038/s41380-018-0271-6 10.1038/s41380-018-0271-6 http://dx.doi.org/10.1038/s41380-018-0271-6 journal Molecular Psychiatry © 2018, The Author(s) 1476-5578 10.1038/s41380-018-0271-6 springer.com springerlink.com 2010-04-23 True 10.1038/s41380-018-0271-6 springer.com springerlink.com Adobe Illustrator CS5.1 2020-04-08T15:58:45+05:30 2020-04-08T15:58:45+05:30 2020-04-08T15:58:45+05:30 True VoR xmp.did:F0E81B155F79EA1192789911B4F9F11E xmp.iid:F0E81B155F79EA1192789911B4F9F11E default 1 uuid:e61e8ba0-e806-4df3-9b0d-c26260ff4735 converted uuid:9e141f34-6983-46e5-91ff-247a7ee60fe2 converted to PDF/A-2b pdfToolbox 2018-11-08T13:20:36+05:30 saved xmp.iid:F0E81B155F79EA1192789911B4F9F11E 2020-04-08T15:58:45+05:30 Adobe Illustrator CS5.1 / uuid:64330ba0-2aaa-467e-83c1-558fac591cac uuid:e61e8ba0-e806-4df3-9b0d-c26260ff4735 uuid:e61e8ba0-e806-4df3-9b0d-c26260ff4735 1 default 2 B 1 False False 210.000274 279.000024 Millimeters Cyan Yellow Default Swatch Group 0 P. L. Germain http://orcid.org/0000-0003-3418-4218 K. L. M. Rudolph http://orcid.org/0000-0002-9866-7051 G. Vernaz http://orcid.org/0000-0001-8942-2370 I. M. Mansuy http://orcid.org/0000-0001-7785-5371 E. A. Miska http://orcid.org/0000-0002-4450-576X http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the name of an author. name Text Gives the ORCID of an author. orcid URI http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text endstream endobj 62 0 obj << /Metadata 63 0 R >> endobj 65 0 obj << /Length 27504 /Subtype /XML /Type /Metadata >> stream application/postscript doi:10.1038/s41380-018-0271-6 Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma K. Gapp G. Steenwyk P. L. Germain W. Matsushima K. L. M. Rudolph F. Manuella M. Roszkowski G. Vernaz T. Ghosh P. Pelczar I. M. Mansuy E. A. Miska Springer US Molecular Psychiatry, doi:10.1038/s41380-018-0271-6 10.1038/s41380-018-0271-6 http://dx.doi.org/10.1038/s41380-018-0271-6 journal Molecular Psychiatry © 2018, The Author(s) 1476-5578 10.1038/s41380-018-0271-6 springer.com springerlink.com 2010-04-23 True 10.1038/s41380-018-0271-6 springer.com springerlink.com Adobe Illustrator CS5.1 2020-04-08T15:58:45+05:30 2020-04-08T15:58:45+05:30 2020-04-08T15:58:45+05:30 True VoR xmp.did:F0E81B155F79EA1192789911B4F9F11E xmp.iid:F0E81B155F79EA1192789911B4F9F11E default 1 uuid:e61e8ba0-e806-4df3-9b0d-c26260ff4735 converted uuid:9e141f34-6983-46e5-91ff-247a7ee60fe2 converted to PDF/A-2b pdfToolbox 2018-11-08T13:20:36+05:30 saved xmp.iid:F0E81B155F79EA1192789911B4F9F11E 2020-04-08T15:58:45+05:30 Adobe Illustrator CS5.1 / uuid:64330ba0-2aaa-467e-83c1-558fac591cac uuid:e61e8ba0-e806-4df3-9b0d-c26260ff4735 uuid:e61e8ba0-e806-4df3-9b0d-c26260ff4735 1 default 2 B 1 False False 210.000274 279.000024 Millimeters Cyan Yellow Default Swatch Group 0 P. L. Germain http://orcid.org/0000-0003-3418-4218 K. L. M. Rudolph http://orcid.org/0000-0002-9866-7051 G. Vernaz http://orcid.org/0000-0001-8942-2370 I. M. Mansuy http://orcid.org/0000-0001-7785-5371 E. A. Miska http://orcid.org/0000-0002-4450-576X http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the name of an author. name Text Gives the ORCID of an author. orcid URI http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text endstream endobj 64 0 obj << /Metadata 65 0 R >> endobj 67 0 obj << /Length 27504 /Subtype /XML /Type /Metadata >> stream application/postscript doi:10.1038/s41380-018-0271-6 Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma K. Gapp G. Steenwyk P. L. Germain W. Matsushima K. L. M. Rudolph F. Manuella M. Roszkowski G. Vernaz T. Ghosh P. Pelczar I. M. Mansuy E. A. Miska Springer US Molecular Psychiatry, doi:10.1038/s41380-018-0271-6 10.1038/s41380-018-0271-6 http://dx.doi.org/10.1038/s41380-018-0271-6 journal Molecular Psychiatry © 2018, The Author(s) 1476-5578 10.1038/s41380-018-0271-6 springer.com springerlink.com 2010-04-23 True 10.1038/s41380-018-0271-6 springer.com springerlink.com Adobe Illustrator CS5.1 2020-04-08T15:58:45+05:30 2020-04-08T15:58:45+05:30 2020-04-08T15:58:45+05:30 True VoR xmp.did:F0E81B155F79EA1192789911B4F9F11E xmp.iid:F0E81B155F79EA1192789911B4F9F11E default 1 uuid:e61e8ba0-e806-4df3-9b0d-c26260ff4735 converted uuid:9e141f34-6983-46e5-91ff-247a7ee60fe2 converted to PDF/A-2b pdfToolbox 2018-11-08T13:20:36+05:30 saved xmp.iid:F0E81B155F79EA1192789911B4F9F11E 2020-04-08T15:58:45+05:30 Adobe Illustrator CS5.1 / uuid:64330ba0-2aaa-467e-83c1-558fac591cac uuid:e61e8ba0-e806-4df3-9b0d-c26260ff4735 uuid:e61e8ba0-e806-4df3-9b0d-c26260ff4735 1 default 2 B 1 False False 210.000274 279.000024 Millimeters Cyan Yellow Default Swatch Group 0 P. L. Germain http://orcid.org/0000-0003-3418-4218 K. L. M. Rudolph http://orcid.org/0000-0002-9866-7051 G. Vernaz http://orcid.org/0000-0001-8942-2370 I. M. Mansuy http://orcid.org/0000-0001-7785-5371 E. A. Miska http://orcid.org/0000-0002-4450-576X http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). 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-30.798 0 l S Q q 1 0 0 1 253.6912 323.338 cm 0 0 m 0 110 l S Q q 1 0 0 1 284.6141 323.338 cm 0 0 m -30.798 0 l S Q q 1 0 0 1 253.6912 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 284.6141 433.338 cm 0 0 m -30.798 0 l S Q q 1 0 0 1 253.6912 563.338 cm 0 0 m 0 148.833 l S Q q 1 0 0 1 284.6141 563.338 cm 0 0 m -30.798 0 l S Q q 1 0 0 1 284.6141 712.0458 cm 0 0 m -30.798 0 l S Q q 1 0 0 1 284.7391 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 305.1621 45.8651 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 284.7391 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 305.1621 138.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 284.7391 192.338 cm 0 0 m 0 57 l S Q q 1 0 0 1 305.1621 192.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 284.7391 249.338 cm 0 0 m 0 74 l S Q q 1 0 0 1 305.1621 249.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 284.7391 323.338 cm 0 0 m 0 110 l S Q q 1 0 0 1 305.1621 323.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 284.7391 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 305.1621 433.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 284.7391 563.338 cm 0 0 m 0 148.833 l S Q q 1 0 0 1 305.1621 563.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 305.1621 712.0458 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 305.2871 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 325.7101 45.8651 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 305.2871 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 325.7101 138.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 305.2871 192.338 cm 0 0 m 0 57 l S Q q 1 0 0 1 325.7101 192.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 305.2871 249.338 cm 0 0 m 0 74 l S Q q 1 0 0 1 325.7101 249.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 305.2871 323.338 cm 0 0 m 0 110 l S Q q 1 0 0 1 325.7101 323.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 305.2871 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 325.7101 433.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 305.2871 563.338 cm 0 0 m 0 148.833 l S Q q 1 0 0 1 325.7101 563.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 325.7101 712.0458 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 325.8351 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 335.7581 45.8651 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 325.8351 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 335.7581 138.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 325.8351 192.338 cm 0 0 m 0 57 l S Q q 1 0 0 1 335.7581 192.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 325.8351 249.338 cm 0 0 m 0 74 l S Q q 1 0 0 1 335.7581 249.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 325.8351 323.338 cm 0 0 m 0 110 l S Q q 1 0 0 1 335.7581 323.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 325.8351 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 335.7581 433.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 325.8351 563.338 cm 0 0 m 0 148.833 l S Q q 1 0 0 1 335.7581 563.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 335.7581 712.0458 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 335.8831 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 345.806 45.8651 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 335.8831 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 345.806 138.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 335.8831 192.338 cm 0 0 m 0 57 l S Q q 1 0 0 1 345.806 192.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 335.8831 249.338 cm 0 0 m 0 74 l S Q q 1 0 0 1 345.806 249.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 335.8831 323.338 cm 0 0 m 0 110 l S Q q 1 0 0 1 345.806 323.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 335.8831 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 345.806 433.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 335.8831 563.338 cm 0 0 m 0 148.833 l S Q q 1 0 0 1 345.806 563.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 345.806 712.0458 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 345.931 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 355.854 45.8651 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 345.931 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 355.854 138.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 345.931 192.338 cm 0 0 m 0 57 l S Q q 1 0 0 1 355.854 192.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 345.931 249.338 cm 0 0 m 0 74 l S Q q 1 0 0 1 355.854 249.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 345.931 323.338 cm 0 0 m 0 110 l S Q q 1 0 0 1 355.854 323.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 345.931 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 355.854 433.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 345.931 563.338 cm 0 0 m 0 148.833 l S Q q 1 0 0 1 355.854 563.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 355.854 712.0458 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 355.979 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 365.902 45.8651 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 355.979 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 365.902 138.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 355.979 192.338 cm 0 0 m 0 57 l S Q q 1 0 0 1 365.902 192.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 355.979 249.338 cm 0 0 m 0 74 l S Q q 1 0 0 1 365.902 249.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 355.979 323.338 cm 0 0 m 0 110 l S Q q 1 0 0 1 365.902 323.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 355.979 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 365.902 433.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 355.979 563.338 cm 0 0 m 0 148.833 l S Q q 1 0 0 1 365.902 563.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 365.902 712.0458 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 366.027 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 375.95 45.8651 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 366.027 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 375.95 138.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 366.027 192.338 cm 0 0 m 0 57 l S Q q 1 0 0 1 375.95 192.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 366.027 249.338 cm 0 0 m 0 74 l S Q q 1 0 0 1 375.95 249.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 366.027 323.338 cm 0 0 m 0 110 l S Q q 1 0 0 1 375.95 323.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 366.027 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 375.95 433.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 366.027 563.338 cm 0 0 m 0 148.833 l S Q q 1 0 0 1 375.95 563.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 375.95 712.0458 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 376.075 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 396.4979 45.8651 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 376.075 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 396.4979 138.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 376.075 192.338 cm 0 0 m 0 57 l S Q q 1 0 0 1 396.4979 192.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 376.075 249.338 cm 0 0 m 0 74 l S Q q 1 0 0 1 396.4979 249.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 376.075 323.338 cm 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0 0 m -9.798 0 l S Q q 1 0 0 1 406.5459 712.0458 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 406.6709 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 416.5939 45.8651 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 406.6709 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 416.5939 138.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 406.6709 192.338 cm 0 0 m 0 57 l S Q q 1 0 0 1 416.5939 192.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 406.6709 249.338 cm 0 0 m 0 74 l S Q q 1 0 0 1 416.5939 249.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 406.6709 323.338 cm 0 0 m 0 110 l S Q q 1 0 0 1 416.5939 323.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 406.6709 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 416.5939 433.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 406.6709 563.338 cm 0 0 m 0 148.833 l S Q q 1 0 0 1 416.5939 563.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 416.5939 712.0458 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 416.7189 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 426.6418 45.8651 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 416.7189 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 426.6418 138.338 cm 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m 0 110 l S Q q 1 0 0 1 436.6898 323.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 426.7668 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 436.6898 433.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 426.7668 563.338 cm 0 0 m 0 148.833 l S Q q 1 0 0 1 436.6898 563.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 436.6898 712.0458 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 436.8148 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 446.7378 45.8651 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 436.8148 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 446.7378 138.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 436.8148 192.338 cm 0 0 m 0 57 l S Q q 1 0 0 1 446.7378 192.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 436.8148 249.338 cm 0 0 m 0 74 l S Q q 1 0 0 1 446.7378 249.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 436.8148 323.338 cm 0 0 m 0 110 l S Q q 1 0 0 1 446.7378 323.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 436.8148 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 446.7378 433.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 436.8148 563.338 cm 0 0 m 0 148.833 l S Q q 1 0 0 1 446.7378 563.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 446.7378 712.0458 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 446.8628 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 456.7858 45.8651 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 446.8628 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 456.7858 138.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 446.8628 192.338 cm 0 0 m 0 57 l S Q q 1 0 0 1 456.7858 192.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 446.8628 249.338 cm 0 0 m 0 74 l S Q q 1 0 0 1 456.7858 249.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 446.8628 323.338 cm 0 0 m 0 110 l S Q q 1 0 0 1 456.7858 323.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 446.8628 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 456.7858 433.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 446.8628 563.338 cm 0 0 m 0 148.833 l S Q q 1 0 0 1 456.7858 563.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 456.7858 712.0458 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 456.9108 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 466.8337 45.8651 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 456.9108 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 466.8337 138.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 456.9108 192.338 cm 0 0 m 0 57 l S Q q 1 0 0 1 466.8337 192.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 456.9108 249.338 cm 0 0 m 0 74 l S Q q 1 0 0 1 466.8337 249.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 456.9108 323.338 cm 0 0 m 0 110 l S Q q 1 0 0 1 466.8337 323.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 456.9108 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 466.8337 433.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 456.9108 563.338 cm 0 0 m 0 148.833 l S Q q 1 0 0 1 466.8337 563.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 466.8337 712.0458 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 466.9587 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 476.8817 45.8651 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 466.9587 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 476.8817 138.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 466.9587 192.338 cm 0 0 m 0 57 l S Q q 1 0 0 1 476.8817 192.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 466.9587 249.338 cm 0 0 m 0 74 l S Q q 1 0 0 1 476.8817 249.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 466.9587 323.338 cm 0 0 m 0 110 l S Q q 1 0 0 1 476.8817 323.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 466.9587 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 476.8817 433.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 466.9587 563.338 cm 0 0 m 0 148.833 l S Q q 1 0 0 1 476.8817 563.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 476.8817 712.0458 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 477.0067 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 486.9297 45.8651 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 477.0067 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 486.9297 138.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 477.0067 192.338 cm 0 0 m 0 57 l S Q q 1 0 0 1 486.9297 192.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 477.0067 249.338 cm 0 0 m 0 74 l S Q q 1 0 0 1 486.9297 249.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 477.0067 323.338 cm 0 0 m 0 110 l S Q q 1 0 0 1 486.9297 323.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 477.0067 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 486.9297 433.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 477.0067 563.338 cm 0 0 m 0 148.833 l S Q q 1 0 0 1 486.9297 563.338 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 486.9297 712.0458 cm 0 0 m -9.798 0 l S Q q 1 0 0 1 487.0547 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 507.4777 45.8651 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 507.6027 45.7401 cm 0 0 m 0 92.598 l S Q q 1 0 0 1 487.0547 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 507.4777 138.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 507.6027 138.338 cm 0 0 m 0 54 l S Q q 1 0 0 1 487.0547 192.338 cm 0 0 m 0 57 l S Q q 1 0 0 1 507.4777 192.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 507.6027 192.338 cm 0 0 m 0 57 l S Q q 1 0 0 1 487.0547 249.338 cm 0 0 m 0 74 l S Q q 1 0 0 1 507.4777 249.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 507.6027 249.338 cm 0 0 m 0 74 l S Q q 1 0 0 1 487.0547 323.338 cm 0 0 m 0 110 l S Q q 1 0 0 1 507.4777 323.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 507.6027 323.338 cm 0 0 m 0 110 l S Q q 1 0 0 1 487.0547 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 507.4777 433.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 507.6027 433.338 cm 0 0 m 0 130 l S Q q 1 0 0 1 487.0547 563.338 cm 0 0 m 0 148.833 l S Q q 1 0 0 1 507.4777 563.338 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 507.4777 712.0458 cm 0 0 m -20.298 0 l S Q q 1 0 0 1 507.6027 563.338 cm 0 0 m 0 148.833 l S Q BT /GS1 gs /T1_1 1 Tf 0 8 -8 0 89.1845 48.7001 Tm [(S)6 (tudy)]TJ 11.559 0 Td (Country)Tj 7.56 1.312 Td [(Number)23.1 ( o)5 (f)20 ( )]TJ -0.436 -1.312 Td [(P)17 (articipants)]TJ 6.751 0 Td (Liquid Sample)Tj 9.25 0 Td [(M)7 (olecular)23 ( M)7 (e)4.1 (thod)]TJ 13.75 0 Td [(M)7 (olecular)23 ( F)34.1 (eatur)8 (e o)5 (f)20 ( Int)7 (er)8.1 (est)]TJ 16.25 0 Td [(T)63 (umor)23 ( E)9 (ntity)]TJ /T1_0 1 Tf -64.684 -1.36 Td (Shah et)Tj /Span<>> BDC 3.47 0 Td ( )Tj EMC (al, 2021)Tj 0 4.664 -4.664 0 97.4035 105.459 Tm (16)Tj -0.006 Tc 0.006 Tw 0 8 -8 0 100.0675 141.1727 Tm [(U)-6 (SA)]TJ 0 Tc 0 Tw 9.526 0 Td (17)Tj 4.349 0 Td (Plasma)Tj -0.012 Tw 9.25 0 Td [(CAPP)13 (-Seq t)7 (ar)12 (get)7.1 (ed )-12 (gene )]TJ 0 Tw 0 -1.312 Td (panel)Tj 13.75 1.312 Td (CNAs)Tj 16.25 0 Td [(E)17 (wing sar)12.1 (c)12 (oma, ost)7 (eosar)12 (c)12 (oma, )]TJ 0 -1.312 Td [(rhabdom)8 (y)11 (osar)12 (c)12 (oma, s)8.1 (yno)11 (vial sar)12 (c)12 (oma)]TJ -64.684 -1.256 Td [(T)91 (ombolan et)]TJ /Span<>> BDC 5.671 0 Td ( )Tj EMC (al, 2022)Tj 0 4.664 -4.664 0 117.9515 124.6109 Tm (18)Tj 0 8 -8 0 120.6155 141.1727 Tm [(I)5 (t)7 (aly)]TJ 9.526 0 Td (17)Tj 4.349 0 Td (Plasma)Tj 9.25 0 Td (ddPCR)Tj 13.75 0 Td [(SNV)47 (s)]TJ 16.25 0 Td [(Rhabdom)8 (y)11 (osar)12 (c)12 (oma)]TJ -64.684 -1.256 Td [(T)91 (ombolan et)]TJ /Span<>> BDC 5.671 0 Td ( )Tj EMC (al, 2018)Tj 0 4.664 -4.664 0 127.9995 123.347 Tm (19)Tj 0 8 -8 0 130.6635 141.1727 Tm [(I)5 (t)7 (aly)]TJ 9.791 0 Td (1)Tj 4.084 0 Td (Plasma)Tj 9.25 0 Td (ddPCR)Tj -0.031 Tw 13.75 0 Td [(BRAF)24 ( V)12 (600E)]TJ 0 Tw 16.25 0 Td [(Rhabdom)8 (y)11 (osar)12 (c)12 (oma)]TJ -64.684 -1.256 Td [(L)60 (y)7 (skj\346r)24 ( et)]TJ /Span<>> BDC 4.575 0 Td ( )Tj EMC (al, 2022)Tj 0 4.664 -4.664 0 138.0474 115.8429 Tm (17)Tj 0 8 -8 0 140.7114 141.1727 Tm [(E)9 (ngland)]TJ 9.43 0 Td (72)Tj 4.445 0 Td (Plasma)Tj 9.25 0 Td (ddPCR)Tj 13.75 0 Td [(M)6 (eth)8 (ylation signatur)12.1 (es)]TJ 16.25 0 Td [(Ost)7 (eosar)12 (c)12 (oma)]TJ -64.684 -1.256 Td (Shulman et)Tj /Span<>> BDC 5.139 0 Td ( )Tj EMC (al, 2018)Tj 0 4.664 -4.664 0 148.0954 119.0909 Tm (14)Tj -0.006 Tc 0.006 Tw 0 8 -8 0 150.7594 141.1727 Tm [(U)-6 (SA)]TJ 0 Tc 0 Tw 8.603 0 Td [(94+)13 (72)]TJ 5.272 0 Td (Plasma)Tj 9.25 0 Td (NGS)Tj 13.75 0 Td [(CNAs, SNV)47 (s)]TJ 16.25 0 Td [(E)17 (wing sar)12.1 (c)12 (oma, ost)7 (eosar)12 (c)12 (oma)]TJ -64.684 -1.256 Td (Krumbholz et)Tj /Span<>> BDC 6.057 0 Td ( )Tj EMC (al, 2016)Tj 0 4.664 -4.664 0 158.1434 126.3868 Tm (13)Tj 0 8 -8 0 160.8074 141.1727 Tm [(German)8 (y)]TJ 9.392 0 Td (20)Tj 4.483 0 Td (Plasma)Tj 9.25 0 Td (ddPCR)Tj 13.75 0 Td [(EW)6 (SR1)]TJ 16.25 0 Td [(E)17 (wing sar)12.1 (c)12 (oma)]TJ -64.684 -1.256 Td [(P)18 (eneder)24 ( et)]TJ /Span<>> BDC 4.927 0 Td ( )Tj EMC (al, 2021)Tj 0 4.664 -4.664 0 168.1913 117.1151 Tm (5)Tj 0 8 -8 0 170.8553 141.1727 Tm [(Int)7 (ernational)]TJ 9.214 0 Td (148)Tj 4.661 0 Td (Plasma)Tj -0.013 Tc 0.013 Tw 9.25 0 Td [(WG)-13 (S)]TJ 0 Tc 0 Tw 13.75 0 Td [(F)36 (r)12 (agment)7 (ation patt)7.1 (ern)]TJ 16.25 0 Td [(E)17 (wing sar)12.1 (c)12 (oma, ost)7 (eosar)12 (c)12 (oma, )]TJ 0 -1.312 Td [(rhabdom)8 (y)11 (osar)12 (c)12 (oma, s)8.1 (yno)11 (vial sar)12 (c)12 (oma)]TJ -64.684 -1.256 Td (Jim\351nez et)Tj /Span<>> BDC 4.706 0 Td ( )Tj EMC (al, 2021)Tj 0 4.664 -4.664 0 188.7393 115.3469 Tm (26)Tj -0.012 Tc 0.012 Tw 0 8 -8 0 191.4033 141.1727 Tm [(F)24 (ra)-12 (n)-11.9 (ce)]TJ 0 Tc 0 Tw 9.514 0 Td (19)Tj 4.361 0 Td (Plasma)Tj 9.25 0 Td (High-deep NGS)Tj 13.75 0 Td (RB1)Tj 16.25 0 Td [(R)21 (etinoblast)7.1 (oma)]TJ -64.684 -1.256 Td [(K)19 (o)5 (thari et)]TJ /Span<>> BDC 4.415 0 Td ( )Tj EMC (al, 2020)Tj 0 4.664 -4.664 0 198.7873 115.1868 Tm (20)Tj -0.006 Tc 0.006 Tw 0 8 -8 0 201.4513 141.1727 Tm [(U)-6 (SA)]TJ 0 Tc 0 Tw 9.489 0 Td (10)Tj 4.386 0 Td (Plasma)Tj 9.25 0 Td (NGS)Tj 13.75 0 Td (RB1)Tj 16.25 0 Td [(R)21 (etinoblast)7.1 (oma)]TJ -64.684 -1.256 Td [(P)18 (olski et)]TJ /Span<>> BDC 3.718 0 Td ( )Tj EMC (al, 2020)Tj 0 4.664 -4.664 0 208.8353 109.6109 Tm (21)Tj -0.006 Tc 0.006 Tw 0 8 -8 0 211.4993 141.1727 Tm [(U)-6 (SA)]TJ 0 Tc 0 Tw 9.374 0 Td (50)Tj 4.501 0 Td (AH)Tj -0.032 Tw 9.25 0 Td [(Shallo)9 (w)24 ( W)13 (GS)]TJ 0 Tw 13.75 0 Td (SCNAs)Tj 16.25 0 Td [(R)21 (etinoblast)7.1 (oma)]TJ -64.684 -1.256 Td [(X)18 (u et)]TJ /Span<>> BDC 2.284 0 Td ( )Tj EMC (al, 2020)Tj 0 4.664 -4.664 0 218.8832 98.1391 Tm (24)Tj -0.006 Tc 0.006 Tw 0 8 -8 0 221.5472 141.1727 Tm [(U)-6 (SA)]TJ 0 Tc 0 Tw 9.384 0 Td (46)Tj 4.491 0 Td (AH)Tj -0.032 Tw 9.25 0 Td [(Shallo)9 (w)24 ( W)13 (GS)]TJ 0 Tw 13.75 0 Td [(SCNAs \()23 (6p ampli\032c)12.1 (ation)41 (\))]TJ 16.25 0 Td [(R)21 (etinoblast)7.1 (oma)]TJ -64.684 -1.256 Td [(Berry)25 ( et)]TJ /Span<>> BDC 3.583 0 Td ( )Tj EMC (al, 2020)Tj 0 4.664 -4.664 0 228.9312 108.5309 Tm (25)Tj -0.006 Tc 0.006 Tw 0 8 -8 0 231.5952 141.1727 Tm [(U)-6 (SA)]TJ 0 Tc 0 Tw 9.526 0 Td (17)Tj 4.349 0 Td (AH, plasma)Tj -0.032 Tw 9.25 0 Td [(Shallo)9 (w)24 ( W)13 (GS)]TJ 0 Tw 13.75 0 Td (SCNAs)Tj 16.25 0 Td [(R)21 (etinoblast)7.1 (oma)]TJ -64.684 -1.256 Td [(Berry)25 ( et)]TJ /Span<>> BDC 3.583 0 Td ( )Tj EMC (al, 2018)Tj 0 4.664 -4.664 0 238.9792 106.6429 Tm (23)Tj -0.006 Tc 0.006 Tw 0 8 -8 0 241.6432 141.1727 Tm [(U)-6 (SA)]TJ 0 Tc 0 Tw 9.417 0 Td (26)Tj 4.458 0 Td (AH)Tj -0.032 Tw 9.25 0 Td [(Shallo)9 (w)24 ( W)13 (GS)]TJ 0 Tw 13.75 0 Td [(SCNAs, M)22 (Y)41 (CN)]TJ 16.25 0 Td [(R)21 (etinoblast)7.1 (oma)]TJ -64.684 -1.256 Td [(Berry)25 ( et)]TJ /Span<>> BDC 3.583 0 Td ( )Tj EMC (al, 2017)Tj 0 4.664 -4.664 0 249.0272 106.3869 Tm (22)Tj -0.006 Tc 0.006 Tw 0 8 -8 0 251.6912 141.1727 Tm [(U)-6 (SA)]TJ 0 Tc 0 Tw 9.691 0 Td (3)Tj 4.184 0 Td (AH)Tj -0.032 Tw 9.25 0 Td [(Shallo)9 (w)24 ( W)13 (GS)]TJ 0 Tw 13.75 0 Td [(CNV)47 (s, RB1)]TJ 16.25 0 Td [(R)21 (etinoblast)7.1 (oma)]TJ -64.684 -1.256 Td [(S)5 (un et)]TJ /Span<>> BDC 2.818 0 Td ( )Tj EMC (al, 2021)Tj 0 4.664 -4.664 0 259.0751 100.2431 Tm (28)Tj 0 8 -8 0 261.7391 141.1727 Tm (China)Tj 9.395 0 Td (58)Tj 4.48 0 Td [(CSF)71 (, plasma)]TJ 9.25 0 Td [(NGS/WE)11 (S)]TJ 13.75 0 Td [(KM)12 (T2D)19 (, KM)12.1 (T2C, SMARCA4, )]TJ 0 -1.312 Td [(BCOR, )29 (TP53, PT)24.1 (CH1, EP300, NF1, )]TJ 0 -1.312 Td (SETD2, MED12, SPEN)Tj 16.25 2.625 Td [(M)6 (edulloblast)7 (oma)]TJ -64.684 -3.881 Td (Li et)Tj /Span<>> BDC 1.862 0 Td ( )Tj EMC (al, 2020)Tj 0 4.664 -4.664 0 290.1231 94.763 Tm (29)Tj -0.006 Tc 0.006 Tw 0 8 -8 0 292.7871 141.1727 Tm [(U)-6 (SA)]TJ 0 Tc 0 Tw 7.304 0 Td [(4+8 health)8 (y)25.1 ( )]TJ 0.847 -1.312 Td [(c)12 (ontr)12 (ols)]TJ 5.724 1.312 Td (CSF)Tj 9.25 0 Td [(W)13 (GBS, CMS-IP)13.1 (-Seq)]TJ 13.75 0 Td [(M)6 (eth)8 (ylation and )]TJ 0 -1.312 Td [(h)8 (y)11 (dr)12 (o)15 (xymeth)8 (ylation signatur)12.2 (es)]TJ 16.25 1.312 Td [(M)6 (edulloblast)7 (oma)]TJ -64.684 -2.568 Td [(Bruz)5 (ek et)]TJ /Span<>> BDC 4.265 0 Td ( )Tj EMC (al, 2020)Tj 0 4.664 -4.664 0 310.6711 113.987 Tm (31)Tj -0.006 Tc 0.006 Tw 0 8 -8 0 313.3351 141.1727 Tm [(U)-6 (SA)]TJ 0 Tc 0 Tw 7.173 0 Td [(12+6 health)8 (y)25.1 ( )]TJ 0.978 -1.312 Td [(c)12 (ontr)12 (ols)]TJ 5.724 1.312 Td (CSF)Tj 9.25 0 Td [(N)10 (anopor)12 (e sequencing)]TJ 13.75 0 Td [(HIS)5 (TIH3B K27M, H3F3A)31.1 ( K27M)]TJ 16.25 0 Td [(p)10 (HGG)]TJ -64.684 -2.568 Td (Li et)Tj /Span<>> BDC 1.862 0 Td ( )Tj EMC (al, 2021)Tj 0 4.664 -4.664 0 331.2191 92.5951 Tm (32)Tj -0.006 Tc 0.006 Tw 0 8 -8 0 333.8831 141.1727 Tm [(U)-6 (SA)]TJ 0 Tc 0 Tw 9.489 0 Td (10)Tj 4.386 0 Td (CSF)Tj 9.25 0 Td (ddPCR)Tj 13.75 0 Td (H3.3K27M)Tj 16.25 0 Td [(D)5 (i\031use midline glioma)]TJ -64.684 -1.256 Td [(S)5 (t)7 (allar)12 (d et)]TJ /Span<>> BDC 4.719 0 Td ( )Tj EMC (al, 2018)Tj 0 4.664 -4.664 0 341.267 115.7312 Tm (33)Tj -0.006 Tc 0.006 Tw 0 8 -8 0 343.931 141.1727 Tm [(U)-6 (SA)]TJ 0 Tc 0 Tw 9.662 0 Td (4)Tj 4.213 0 Td (CSF)Tj 9.25 0 Td (ddPCR)Tj 13.75 0 Td [(H3F3A)31 ( K27M)]TJ 16.25 0 Td [(p)10 (HGG)9 (, D)5 (i\031use midline glioma)]TJ -64.684 -1.256 Td [(Mueller)24 ( et)]TJ /Span<>> BDC 4.59 0 Td ( )Tj EMC (al, 2019)Tj 0 4.664 -4.664 0 351.315 114.6431 Tm (35)Tj -0.006 Tc 0.006 Tw 0 8 -8 0 353.979 141.1727 Tm [(U)-6 (SA)]TJ 0 Tc 0 Tw 9.526 0 Td (17)Tj 4.349 0 Td (Plasma)Tj 9.25 0 Td (ddPCR)Tj 13.75 0 Td [(HIS)5 (TIH3B K27M, H3F3A)31.1 ( K27M)]TJ 16.25 0 Td [(D)5 (i\031use midline glioma)]TJ -64.684 -1.256 Td [(Cant)7 (or)24 ( et)]TJ /Span<>> BDC 4.254 0 Td ( )Tj EMC (al, 2022)Tj 0 4.664 -4.664 0 361.363 113.275 Tm (34)Tj -0.006 Tc 0.006 Tw 0 8 -8 0 364.027 141.1727 Tm [(U)-6 (SA)]TJ 0 Tc 0 Tw 9.414 0 Td (28)Tj 4.461 0 Td [(CSF)71 (, plasma)]TJ 9.25 0 Td (ddPCR)Tj 13.75 0 Td [(H3F3A)31 ( K27M)]TJ 16.25 0 Td [(D)5 (i\031use midline glioma)]TJ -64.684 -1.256 Td [(P)18 (ag\350s et)]TJ /Span<>> BDC 3.931 0 Td ( )Tj EMC (al, 2022)Tj 0 4.664 -4.664 0 371.4109 110.691 Tm (30)Tj -0.006 Tc 0.006 Tw 0 8 -8 0 374.075 141.1727 Tm [(U)-6 (SA)]TJ 0 Tc 0 Tw 9.132 0 Td (258)Tj 4.743 0 Td [(CSF)71 (, plasma, urine)]TJ 9.25 0 Td [(ULP)13 (-)29 (W)13 (GS deep sequencing)]TJ 13.75 0 Td [(SCNAs, SNV)47.1 (s)]TJ 16.25 0 Td [(Ov)11 (er)24 ( 13 )12 (types o)6.1 (f)21 ( CNS )12 (tumor)4 (s)]TJ -64.684 -1.256 Td (Applebaum et)Tj /Span<>> BDC 6.454 0 Td ( )Tj EMC (al, )Tj -6.454 -1.312 Td (2020)Tj 0 4.664 -4.664 0 391.9589 66.8115 Tm (43)Tj -0.006 Tc 0.006 Tw 0 8 -8 0 384.1229 141.1727 Tm [(U)-6 (SA)]TJ 0 Tc 0 Tw 6.768 0 Td [(53+34 health)8.1 (y)25 ( )]TJ 1.383 -1.312 Td [(c)12 (ontr)12 (ols)]TJ 5.724 1.312 Td (Plasma)Tj -0.012 Tw 9.25 0 Td [(N)10 (ano-hm)7 (C-Seal t)7 (echnology)]TJ 0 Tw 13.75 0 Td [(5-hm)7 (C)]TJ 16.25 0 Td [(N)10 (eur)12 (oblast)7 (oma)]TJ -64.684 -2.568 Td [(S)5 (u et)]TJ /Span<>> BDC 2.255 0 Td ( )Tj EMC (al, 2020)Tj 0 4.664 -4.664 0 402.0069 97.9072 Tm (36)Tj 0 8 -8 0 404.6709 141.1727 Tm (China)Tj 9.346 0 Td (116)Tj 4.529 0 Td (Plasma)Tj 9.25 0 Td (qPCR)Tj 13.75 0 Td [(cfDNA)31 ( c)12 (onc)12.1 (entr)12 (ation)]TJ 16.25 0 Td [(N)10 (eur)12 (oblast)7 (oma)]TJ -64.684 -1.256 Td [(S)5 (u et)]TJ /Span<>> BDC 2.255 0 Td ( )Tj EMC (al, 2019)Tj 0 4.664 -4.664 0 412.0549 95.9632 Tm (37)Tj 0 8 -8 0 414.7189 141.1727 Tm (China)Tj 9.395 0 Td (58)Tj 4.48 0 Td (Plasma)Tj 9.25 0 Td (qPCR)Tj 13.75 0 Td [(cfDNA)31 ( c)12 (onc)12.1 (entr)12 (ation)]TJ 16.25 0 Td [(N)10 (eur)12 (oblast)7 (oma)]TJ -64.684 -1.256 Td [(I)10 (ehar)12 (a et)]TJ /Span<>> BDC 4.139 0 Td ( )Tj EMC (al, 2019)Tj 0 4.664 -4.664 0 422.1028 111.035 Tm (38)Tj 0 8 -8 0 424.7668 141.1727 Tm [(J)10 (apan)]TJ 9.375 0 Td (80)Tj 4.5 0 Td (Plasma)Tj 9.25 0 Td [(qR)6 (T)55 (-PCR)]TJ -0.041 Tc 0.041 Tw 13.75 0 Td [(M)-19 (YC)-41 (N)]TJ 0 Tc 0 Tw 16.25 0 Td [(N)10 (eur)12 (oblast)7 (oma)]TJ -64.684 -1.256 Td [(Combar)12 (et)19 ( et)]TJ /Span<>> BDC 5.74 0 Td ( )Tj EMC (al, 2015)Tj 0 4.664 -4.664 0 432.1508 123.915 Tm (42)Tj -0.012 Tc 0.012 Tw 0 8 -8 0 434.8148 141.1727 Tm [(F)24 (ra)-12 (n)-11.9 (ce)]TJ 0 Tc 0 Tw 9.328 0 Td (114)Tj 4.547 0 Td (Plasma)Tj 9.25 0 Td (ddPCR)Tj 13.75 0 Td (ALK)Tj 16.25 0 Td [(N)10 (eur)12 (oblast)7 (oma)]TJ -64.684 -1.256 Td [(Chic)12 (ar)12 (d 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P)18.1 (o)4.9 (t)7 (entially)25 ( pr)12 (ognostic genetic )14.4 (f)7 (eatur)12 (e\2278q )]TJ 0.084 Tw 0 -1.294 Td [(gain )12 (that)19 ( harbor)4 (s M)22 (Y)41 (C gene )23.9 (w)10 (as det)7 (ect)7 (able in 7)64 (4.5% ct)5 (DNA-)]TJ 0.182 Tw 0 -1.294 Td [(positiv)11.1 (e patients. )29 (Their)24 ( 3-)14 (y)11 (ear)24 ( e)9 (v)11 (ent)19 (-)16 (fr)12 (ee surviv)11 (al )23.9 (w)10 (as lo)9 (w)10 (er)23.9 ( )]TJ 0 Tw 0 -1.294 Td [(than in patients )24 (without)19 ( 8q gain\22760% c)12 (ompar)12 (ed )12 (t)7 (o 80.9%.)]TJ 4.9555 0 0 4.9555 281.1749 179.5595 Tm (14)Tj 0.086 Tw 8.5 0 0 8.5 56.6929 157.225 Tm [(The abo)11 (v)11 (e-mentioned CAPP)13 (-Seq )0.5 (ct)5 (DNA)31 ( assay)25 ( det)7 (ect)7 (ed )29.5 (TP53 )]TJ 0.327 Tw 0 -1.294 Td [(tr)12 (ansloc)12 (ations in 3/3 patients )24.4 (with kno)9 (wn )0.5 (aberr)12 (ation )0.5 (at)19 ( a )]TJ 0.152 Tw 0 -1.294 Td [(median )31.4 (AF)24 ( o)6 (f)21 ( 1.2%. )29.3 (The )31.4 (A)51 (TRX intr)12 (onic )12.4 (tr)12 (ansloc)12 (ations )12.3 (that)19.1 ( ar)12.1 (e )]TJ 0.291 Tw 0 -1.294 Td [(normally)25.1 ( pr)12.1 (esent)19 ( in 14% o)6 (f)21 ( ost)7 (eosar)12 (c)12 (oma )12.2 (tumor)4 (s )24.2 (w)10 (er)12 (e no)5 (t)19 ( )]TJ 0.223 Tw 0 -1.294 Td [(identi\032ed in an)8 (y)25 ( o)6 (f)21.1 ( )12.1 (the patients in )12.1 (the study)38.1 (. Cop)11 (y)25 ( number)24 ( )]TJ -0.014 Tw 0 -1.294 Td [(alt)7 (er)12 (ations )24.4 (w)10 (er)12 (e det)7 (ect)7 (ed )12.4 (thr)12 (oughout)19.1 ( )12.3 (the genome including 8q )]TJ -0.012 Tw 0 -1.294 Td [(gain\227suggestiv)11 (e )-12 (o)6 (f)21 ( )-12 (possible )19 (A)51 (T7519 t)7 (ar)12 (get)7 (ed tr)12 (eatment)19 (.)]TJ 0 Tw 4.9555 0 0 4.9555 272.8458 94.0555 Tm (16)Tj 0.174 Tw 8.5 0 0 8.5 56.6929 71.7211 Tm [(The analy)7 (sis o)6 (f)21 ( ct)5 (DNA)31 ( meth)8.1 (ylation patt)7 (erns arises as a ne)7 (w)24 ( )]TJ 0.184 Tw 0 -1.294 Td [(appr)12 (oach )0.5 (in )0.5 (ost)7 (eosar)12 (c)12 (oma )0.5 (diagnosis. )0.5 (I)5 (t)19 ( )0.5 (pr)12 (esents )0.5 (a )25.5 (v)11 (aluable )]TJ 0.151 Tw 0 -1.294 Td [(biomark)29 (er)24 ( as meth)8 (ylation o)6 (f)21 ( CpG islands oc)12 (cur)4 (s as an early)25 ( )]TJ 0.049 Tw 29.886 77.179 Td [(e)9 (v)11 (ent)19 ( in )12 (tumor)24 ( )12.1 (tissue )14 (f)7.1 (ormation and r)12 (emains c)12 (onst)7 (ant)19.1 ( )12 (thr)12 (ough )]TJ 0.183 Tw 0 -1.294 Td [(tumor)24 ( e)9 (v)11 (olution. U)10 (sing 2 duple)10 (x)15 (ed ddPCR assay)7 (s c)12 (ont)7 (aining )]TJ 0.281 Tw 0 -1.294 Td [(meth)8 (ylation mark)29 (er)4 (s c)12 (g02169391, c)12 (g22082800, c)12 (g25680486, )]TJ 0.221 Tw 0 -1.294 Td [(and c)12 (g26100986, 40% o)6 (f)21 ( patients )24.3 (w)10 (er)12 (e e)9 (v)11 (aluat)7 (ed as ct)5 (DNA)31.1 ( )]TJ 0.253 Tw 0 -1.294 Td [(ost)7 (eosar)12 (c)12 (oma )0.6 (positiv)10.9 (e )0.6 (aft)7 (er)24 ( )0.6 (setting )0.6 (a )0.6 (minimum )0.6 (o)6 (f)21 ( )0.6 (2 )0.5 (mark)]TJ 0 Tw 27.988 0 Td (-)Tj 0.259 Tw -27.988 -1.294 Td [(er)4 (s as a limit)19 ( o)6 (f)21 ( det)7 (ection. )30.7 (A)31 ( higher)24 ( r)12 (at)7 (e o)6 (f)21 ( det)7 (ection )23.7 (w)10 (as )]TJ 0.2 Tw 0 -1.294 Td [(observ)11 (ed among patients )23.7 (with met)7 (ast)7 (asiz)5 (ed )24.8 (v)10.9 (er)4.1 (sus patients )]TJ 0 Tw 0 -1.294 Td [(with loc)12 (aliz)5 (ed disease\22763% c)12 (ompar)12.1 (ed )24.1 (with 32%. )29.2 (The det)6.9 (ection )]TJ 0.201 Tw 0 -1.294 Td [(o)6 (f)21 ( pr)12 (etr)12 (eatment)19 ( ct)5 (DNA)31 ( )24.2 (w)10 (as associat)7 (ed )24.2 (with inf)7.1 (erior)24 ( surviv)11 (al )]TJ 0.037 Tw 0 -1.294 Td [(out)7 (c)12 (omes but)19 ( no)5 (t)19 ( )23.8 (with )11.8 (tumor)24 ( siz)5 (e. F)37 (alse-positiv)11 (e ct)5 (DNA)31 ( r)12 (esults )]TJ 0 Tw 0 -1.294 Td [(w)10 (er)12 (e observ)11 (ed in 2.6% o)6 (f)21 ( health)8 (y)25.1 ( patients.)]TJ 4.9555 0 0 4.9555 473.3444 598.5753 Tm (17)Tj /T1_1 1 Tf 8.5 0 0 8.5 310.7244 574.7448 Tm [(R)5 (habdom)6 (y)10 (osar)8 (c)6 (oma. )]TJ /T1_0 1 Tf 0.323 Tw 10.351 0 Td [(Rhabdom)8 (y)11 (osar)12 (c)12 (oma is an aggr)12 (essiv)11 (e )]TJ -0.013 Tw -10.351 -1.294 Td [(malignant)19.1 ( )12.2 (tumor)24.1 ( o)6 (f)21 ( striat)7 (ed muscle origin. I)5 (t)19.1 ( deriv)11 (es )14.3 (fr)12 (om mes)]TJ 0 Tw (-)Tj 0.045 Tw 0 -1.294 Td [(ench)8 (ymal tissue that)19 ( )1.6 (f)7 (ailed t)6.9 (o )-12.4 (c)12 (omplet)7 (e )-12.4 (m)8.1 (y)11 (ogenic )-12.4 (di\031)7 (er)12.1 (entia)]TJ 0 Tw (-)Tj 0.041 Tw 0 -1.294 Td [(tion but)19.1 ( r)12 (et)7 (ained e)10 (xpr)12 (ession o)6 (f)21 ( desmin and m)8 (y)11 (ogenin. Despit)7 (e )]TJ 0.298 Tw 0 -1.294 Td [(impr)12 (o)11 (v)11 (ement)19 ( in )11.9 (ther)12.1 (ap)11 (y)38 (, it)19 ( is still char)12 (act)7.1 (eriz)5 (ed b)11 (y)25 ( a high )]TJ 0.14 Tw 0 -1.294 Td [(mort)7 (ality)25 ( r)12 (at)7 (e in childr)12 (en and adolesc)12 (ents\227up )11.8 (t)7 (o 70% o)11 (v)11 (er)24 ( 3 )]TJ 0.026 Tw 0 -1.294 Td [(y)11 (ear)4 (s in patients )23.8 (with met)7 (ast)7 (ases at)19 ( )11.8 (the )11.9 (time o)6.1 (f)20.9 ( diagnosis. )28.9 (The )]TJ 0.301 Tw 0 -1.294 Td [(most)19 ( )0.5 (c)12 (ommon )0.5 (hist)7 (ologic)12 (al )0.5 (sub)5 (types )0.5 (o)6 (f)21 ( )0.5 (rhabdom)8 (y)10.9 (osar)12 (c)12 (oma )]TJ 0.194 Tw 0 -1.294 Td [(ar)12 (e embry)11.1 (onal \()23 (60% o)6 (f)21 ( c)12 (ases)39 (\), alv)11 (eolar)24 ( \(30%\), and bo)5 (try)11 (oid )]TJ 0 Tw 0 -1.294 Td (\(10%\).)Tj 4.9555 0 0 4.9555 332.9346 478.5753 Tm [(18,)22 (19)]TJ 0.205 Tw 8.5 0 0 8.5 310.7244 454.7448 Tm [(T)91 (ombolan et)]TJ /Span<>> BDC 5.876 0 Td ( )Tj EMC (al)Tj 0 Tw 4.9555 0 0 4.9555 371.8882 457.5753 Tm (18)Tj 0.205 Tw 8.5 0 0 8.5 376.3283 454.7448 Tm [( ob)5 (t)7 (ained multiple plasma samples )14.1 (fr)12 (om 17 )]TJ 0.07 Tw -7.718 -1.294 Td [(pediatric patients during )12.4 (the c)12 (our)4 (se o)6 (f)21 ( )12.3 (tr)12.1 (eatment)19 ( and quanti)]TJ 0 Tw (-)Tj 0.053 Tw 0 -1.294 Td [(\032ed bo)5 (th cir)12.1 (culating )12.2 (tumor)24 ( c)12 (ells and cfDNA)31 ( at)19 ( di\031)7 (er)12 (ent)19.1 ( points )]TJ -0.05 Tw 0 -1.294 Td [(o)6 (f)21 ( disease st)7 (at)7 (es. )28.7 (The)9 (y)25 ( )13.7 (f)7 (ound a positiv)11 (e c)12 (orr)12.1 (elation betw)10 (een )11.7 (the )]TJ 0.065 Tw 0 -1.294 Td [(number)24 ( o)6 (f)21 ( CT)24 (Cs and cfDNA)31.1 ( le)9 (v)11 (els. )31 (A)15 (ft)7 (er)24 ( pr)12 (oc)12 (essing )11.9 (tumor)23.9 ( )12 (tis)]TJ 0 Tw (-)Tj 0.014 Tw 0 -1.294 Td [(sue ob)5 (t)7 (ained b)11 (y)25 ( biops)8.1 (y)25 ( b)11 (y)25 ( )23.7 (whole e)10 (x)15 (ome sequencing and iden)]TJ 0 Tw (-)Tj 0.052 Tw 0 -1.294 Td [(tifying somatic alt)7 (er)12.1 (ations \()16 (MAP3K4, FE)11 (S, F)8 (GFR)13 (4, MCTP1, )28.8 (TEK, )]TJ 0.08 Tw 0 -1.294 Td [(S)5 (T)52 (A)15 (G2\), )11.7 (the)9 (y)25 ( also managed )11.8 (t)7 (o det)7 (ect)19 ( )11.7 (them in cfDNA)31.1 ( samples )]TJ 0.027 Tw 0 -1.294 Td [(using ddPCR )12.3 (t)7 (echnology)38 (. )29.2 (The)9 (y)25 ( demonstr)12 (at)7 (ed )12.2 (the po)5 (t)7 (ential use )]TJ -0.011 Tw 0 -1.294 Td [(o)6 (f)21 ( )12.3 (these )12.3 (tr)12 (acking biomark)29.1 (er)4 (s )14.2 (f)7 (or)24 ( )12.3 (the e)9 (v)11 (aluation o)6 (f)21 ( disease e)9 (v)11 (o)]TJ 0 Tw (-)Tj 0 -1.294 Td [(lution and pr)12 (ediction o)6 (f)21 ( r)12 (elapse.)]TJ 4.9555 0 0 4.9555 434.2192 347.5753 Tm (18)Tj 0.388 Tw 8.5 0 0 8.5 310.7244 323.7448 Tm [(S)5 (imilarly)38.1 (, lik)29 (e E)17 (wing sar)12 (c)12 (oma, rhabdom)8 (y)11 (osar)12 (c)12 (oma is also )]TJ -0.039 Tw 0 -1.294 Td [(char)12 (act)7 (eriz)5 (ed b)11 (y)25 ( )0.5 (c)12 (anonic )14.5 (fusion )0.5 (genes )0.5 (P)38 (AX3-F)8.1 (O)22 (X)22 (O1 )0.5 (and )0.5 (P)38 (AX7)49 (-)]TJ 0.011 Tw 0 -1.294 Td [(F)8 (O)22 (X)22 (O1 )23.8 (which ar)12 (e associat)7 (ed )23.8 (with dismal pr)12 (ognosis. CAPP)13 (-Seq )]TJ 0.066 Tw 0 -1.294 Td [(appr)12 (oach managed )11.7 (t)7 (o det)7 (ect)19 ( P)38 (AX3-F)8.1 (O)21.9 (X)22 (O1 gene in 3 patients )]TJ 0.07 Tw 0 -1.294 Td [(with a median )31.2 (AF)24 ( o)6 (f)21 ( 10.7%. )29.2 (The analy)7 (sis o)6 (f)21 ( ct)5 (DNA)31 ( o)6 (f)21 ( a patient)19 ( )]TJ 0.177 Tw 0 -1.294 Td [(su\031)7 (ering )14.5 (fr)12 (om alv)11 (eolar)24 ( )0.5 (rhabdom)8 (y)11 (osar)12 (c)12 (oma )0.5 (r)12 (e)8.9 (v)11 (ealed )0.5 (a r)12 (ar)12 (e )]TJ 0.293 Tw 0 -1.294 Td [(P)38 (AX3-NCO)15 (A)14 (1 )12.5 (tr)12 (ansloc)12 (ation )24.5 (which )0.6 (is )0.5 (also )0.5 (associat)7 (ed )24.5 (with )0.5 (a )]TJ 0.17 Tw 0 -1.294 Td [(w)10 (or)4 (se pr)12 (ognosis. )29.2 (This appr)12 (oach managed )12.2 (t)7 (o pr)12 (edict)19.1 ( clinic)12 (al )]TJ 0.142 Tw 0 -1.294 Td [(r)12 (elapse )0.5 (b)11 (y)25 ( )0.5 (r)12 (ec)12 (ognizing )0.5 (ne)7 (w)24 ( )0.5 (positivity)25 ( )14.5 (f)7 (or)24 ( )0.5 (P)38 (AX3-NCO)15 (A)14 (1 )14.4 (fusion )]TJ 0 Tw 0 -1.294 Td [(gene in )12.1 (the plasma o)6 (f)21 ( an RMS patient)19 ( in r)12 (emission.)]TJ 4.9555 0 0 4.9555 506.9781 227.5753 Tm (16)Tj 0.153 0.961 0.902 0.051 k /GS0 gs /T1_1 1 Tf 8.5 0 0 8.5 310.7244 203.7448 Tm [(R)21 (e)4 (tinoblast)7 (oma)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.183 Tw 0 -1.294 Td [(R)21 (etinoblast)7 (oma is )11.8 (the most)19 ( c)12 (ommon intr)12 (aocular)24 ( malignanc)4.1 (y)25 ( )]TJ 0.114 Tw 0 -1.294 Td [(in )12.1 (the pediatric population )24 (with an annual incidenc)12 (e o)6 (f)21 ( 10-)20 (14 )]TJ 0.189 Tw 0 -1.294 Td [(c)12 (ases per)24 ( million.)]TJ 0 Tw 4.9555 0 0 4.9555 380.7545 173.5753 Tm (20)Tj 0.189 Tw 8.5 0 0 8.5 386.3641 170.7448 Tm [( )29 (The initiating )14 (f)7 (act)7 (or)24 ( )14.1 (f)7 (or)24 ( )12 (tumor)24 ( genesis is )]TJ 0.092 Tw -8.899 -1.294 Td [(the biallelic inactiv)11 (ation o)6 (f)21 ( RB1 )12.3 (tumor)24 ( suppr)12 (essor)24 ( gene. )0.5 (In )12.4 (the )]TJ -0.02 Tw 0 -1.294 Td [(her)12 (edit)7 (ary)25.1 ( )13.9 (f)7 (orm o)6 (f)21 ( disease, )23.9 (which pr)12 (esent)7 (ed in 40% o)6 (f)21 ( patients, )]TJ 0.121 Tw 0 -1.294 Td [(1 mut)7 (ant)19.1 ( allele originat)7.1 (es )13.7 (fr)12 (om germline c)12 (ells )23.7 (while )11.7 (the o)5 (ther)24 ( )]TJ 0.099 Tw 0 -1.294 Td [(mut)7 (ation is somatic and oc)12 (cur)4.1 (s in )12.1 (the r)12 (etinal c)12 (ell. In )12.1 (the c)12 (ase )]TJ 0.057 Tw 0 -1.294 Td [(o)6 (f)21 ( a non-her)12 (edit)7.1 (ary)25 ( )12.4 (tumor)58 (, bo)5 (th alleles ar)12 (e inactiv)11 (at)7 (ed due )12.4 (t)7 (o )]TJ 0.119 Tw 0 -1.294 Td [(somatic mut)7 (ations. Sec)12 (ondary)25 ( genomic e)9 (v)11 (ents such as chr)12 (o)]TJ 0 Tw (-)Tj 0.414 Tw 0 -1.294 Td [(mosomal r)12 (earr)12.1 (angements\227in particular)58 (, r)12 (ecurr)12 (ent)19.1 ( somatic )]TJ 0.022 Tw 0 -1.294 Td [(c)12 (op)11 (y)25 ( number)24 ( alt)7 (er)12 (ations c)12 (ontribut)7 (e )12.3 (t)7 (o disease pr)12 (ogr)12 (ession.)]TJ 0 Tw 4.9555 0 0 4.9555 539.5844 85.5752 Tm [(20-)14 (22)]TJ 8.5 0 0 8.5 552.7559 82.7448 Tm ( )Tj 0.139 Tw -28.474 -1.294 Td [(R)21 (etinoblast)7 (oma belongs )12.4 (t)7 (o a gr)12 (oup o)6 (f)21 ( r)12 (ar)12 (e c)12 (anc)12 (er)4 (s in )24.4 (which )]TJ 0.375 Tw 0 -1.294 Td [(biops)8 (y)25 ( )0.5 (is )0.5 (c)12 (ontr)12 (aindic)12 (at)7 (ed )0.5 (due )12.5 (t)7 (o )12.5 (the )0.5 (risk )0.5 (o)6 (f)21 ( )12.5 (tumor)24 ( )0.5 (seed)]TJ 0 Tw (-)Tj 0.091 Tw 0 -1.294 Td [(ing. 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)25.3 (v)11 (alue in neur)12 (oblast)7 (oma patients.)]TJ 0 Tw 4.9555 0 0 4.9555 252.2201 100.0633 Tm (39)Tj 0.142 Tw 8.5 0 0 8.5 257.6215 97.2328 Tm [( R)21 (ecurr)12 (ent)19.1 ( )]TJ -0.011 Tw -23.639 -1.294 Td [(segment)7 (al chr)12 (omosomal alt)7 (er)12 (ations, such as 17q gain, 1p dele)]TJ 0 Tw (-)Tj 0.195 Tw 0 -1.294 Td [(tion, and 11q deletion, ar)12 (e associat)7 (ed )23.8 (with dismal pr)12 (ognosis )]TJ 0.192 Tw 0 -1.294 Td [(wher)12 (eas numeric)12 (al chr)12.1 (omosomal alt)7 (er)12 (ations o)6.1 (\031)6.9 (er)24 ( op)5 (timistic )]TJ 0.01 Tw 0 -1.294 Td [(pr)12 (ojections. )28.6 (The r)12 (at)7 (e o)6 (f)21 ( r)12 (ecurr)12 (ent)19 ( somatic mut)7 (ations is lo)9 (w)33 (, )11.6 (the )]TJ 0.149 Tw 29.886 76.766 Td [(most)19 ( c)12 (ommonly)25 ( e)9 (v)11 (aluat)7 (ed being M)22 (Y)41 (CN and anaplastic lym)]TJ 0 Tw (-)Tj 0 -1.294 Td [(phoma kinase \()35 (ALK\).)]TJ 4.9555 0 0 4.9555 390.3684 697.5753 Tm [(39)10 (,40)]TJ 0.151 Tw 8.5 0 0 8.5 310.7244 674.7448 Tm [(The ampli\032c)12 (ation o)6 (f)21 ( M)22 (Y)41 (CN onc)12.1 (ogene pr)12 (esent)19 ( in 20%-)14 (25% o)6 (f)21 ( )]TJ -0.014 Tw 0 -1.294 Td [(patients is )0.5 (associat)7.1 (ed )24.4 (with )0.5 (an )0.5 (aggr)12 (essiv)11 (e )14.5 (f)7 (orm )0.5 (o)6 (f)21 ( )12.5 (the disease.)]TJ 0 Tw 4.9555 0 0 4.9555 546.8242 666.5753 Tm (40)Tj 8.5 0 0 8.5 552.7559 663.7448 Tm ( )Tj -0.015 Tw -28.474 -1.294 Td [(I)5 (t)19 ( is assessed b)11 (y)25 ( M)22 (Y)41 (CN/N-ac)12 (etyl gluc)12 (osamine kinase r)12 (atio. )29.1 (The )]TJ 0.017 Tw 0 -1.294 Td [(NA)15 (GK)11 ( \(2p12.3)17 (\) gene is used as a r)12 (ef)7 (er)12 (enc)12 (e bec)12 (ause o)6 (f)21 ( its posi)]TJ 0 Tw (-)Tj -0.042 Tw 0 -1.294 Td [(tion close )11.7 (t)7 (o )11.8 (the c)12 (entr)12.1 (omer)12 (e o)6 (f)21 ( )11.8 (the same chr)12.1 (omosome on )23.7 (which )]TJ 0.122 Tw 0 -1.294 Td [(M)22 (Y)41 (CN )0.6 (\(2p24)21 (\) )0.5 (is )0.5 (loc)12 (at)7 (ed.)]TJ 0 Tw 4.9555 0 0 4.9555 407.1165 622.5753 Tm (38)Tj 0.122 Tw 8.5 0 0 8.5 412.5526 619.7448 Tm [( )0.5 (In )0.6 (c)12 (omparison )12.5 (t)7 (o )12.6 (the )0.5 (biopsied )0.5 (pri)]TJ 0 Tw (-)Tj 0.065 Tw -11.98 -1.294 Td [(mary)25 ( )12.1 (tumor)24 ( )12 (tissue e)9 (v)11 (aluation b)11 (y)25 ( Int)7 (erphase FISH \(I-FISH\) and )]TJ 0.28 Tw 0 -1.294 Td [(Southern blo)5 (tting, ct)5 (DNA)31 ( analy)7 (sis b)11 (y)25 ( r)12 (eal-)13 (time quantit)7 (ativ)11 (e )]TJ 0.102 Tw 0 -1.294 Td [(polymer)12 (ase chain r)12 (eaction \(PCR\) and )11.9 (the r)12 (atio o)6.1 (f)21 ( M)22 (Y)41 (CN and )]TJ 0.108 Tw 0 -1.294 Td [(NA)15 (GK)11 ( gene dosage \()16 (M/N r)12.1 (atio)45 (\) det)7 (ect)7 (ed M)22 (Y)41 (CN gene ampli)]TJ 0 Tw (-)Tj 0.096 Tw 0 -1.294 Td [(\032c)12 (ation )23.6 (with a sensitivity)25 ( o)6 (f)21 ( 86%-)20.1 (100% and speci\032city)25 ( o)6 (f)21 ( 95%-)]TJ 0.103 Tw 0 -1.294 Td [(100%. )32 (While I)10 (ehar)12 (a et)]TJ /Span<>> BDC 9.95 0 Td ( )Tj EMC (al)Tj 0 Tw 4.9555 0 0 4.9555 405.6515 556.5753 Tm (38)Tj 0.103 Tw 8.5 0 0 8.5 411.0876 553.7448 Tm [( c)12 (orr)12 (ectly)25.1 ( classi\032ed all )12 (the samples, )]TJ -0.045 Tw -11.807 -1.294 Td [(Y)107 (agyu et)]TJ /Span<>> BDC 3.895 0 Td ( )Tj EMC (al)Tj 0 Tw 4.9555 0 0 4.9555 352.9218 545.5753 Tm (41)Tj -0.045 Tw 8.5 0 0 8.5 357.5106 542.7448 Tm [( observ)11 (ed lo)9 (w)10 (er)24 ( sensitivity)25 ( o)6 (f)21 ( just)19 ( 67% in st)7 (age 1 and )]TJ 0.045 Tw -5.504 -1.294 Td [(st)7 (age 2 neur)12 (oblast)7 (oma c)12 (ases. )29.4 (The M)22 (Y)41 (CN ampli\032c)12 (ation \()16 (MNA)34 (\) )]TJ -0.026 Tw 0 -1.294 Td [(st)7 (atus is pr)12 (o)11 (v)11 (en as a )24.7 (v)11 (aluable negativ)11 (ely)25 ( associat)7 (ed pr)12 (ognostic )]TJ -0.049 Tw 0 -1.294 Td [(f)7 (act)7 (or)24 ( in inf)7.1 (antile NB )23.8 (while )11.8 (the st)7 (atistic)12 (ally)25 ( signi\032c)12 (ant)19 ( di\031)7 (er)12 (enc)12 (e )]TJ 0.039 Tw 0 -1.294 Td [(in surviv)11 (al betw)10 (een MNA-positiv)11 (e and MNA-negativ)11 (e patients )]TJ 0 Tw 0 -1.294 Td [(o)11 (v)11 (er)24 ( 18 months o)6 (f)21 ( age )24 (w)10 (as no)5 (t)19 ( observ)11 (ed.)]TJ 4.9555 0 0 4.9555 468.1517 490.5753 Tm (41)Tj 0.191 Tw 8.5 0 0 8.5 310.7244 467.7448 Tm [(A)8 (ctiv)11 (ating )0.6 (mut)7 (ation )0.5 (o)6 (f)21 ( )31.5 (ALK)11 ( )12.5 (tyr)12 (osine )0.6 (kinase )0.5 (r)12 (ec)12 (ep)5 (t)7 (or)24 ( )0.5 (bec)12 (ame )]TJ 0.088 Tw 0 -1.294 Td [(the c)12 (ent)7 (er)24 ( o)6 (f)21 ( int)7 (er)12 (est)19.1 ( aft)7 (er)24 ( )12.1 (the de)9 (v)11 (elopment)19.1 ( o)6 (f)21 ( )12.1 (t)7 (ar)12 (get)7 (ed )12 (ther)]TJ 0 Tw 27.988 0 Td (-)Tj 0.123 Tw -27.988 -1.294 Td [(ap)11 (y)25 ( )24.4 (with criz)5 (o)5 (tinib. )29.4 (The )0.5 (mut)7 (ation )0.5 (o)6 (f)21 ( )31.4 (ALK)11 ( )0.5 (is )0.5 (pr)12 (esent)19 ( in )0.5 (8%-)20 (10% )]TJ 0.152 Tw 0 -1.294 Td [(o)6 (f)21 ( neur)12 (oblast)7 (oma patients at)19.1 ( )12 (the )12.1 (time o)6 (f)21 ( diagnosis. )29.1 (T)91 (o dat)7 (e, )]TJ 0.162 Tw 0 -1.294 Td [(mor)12 (e )12.1 (than 50 di\031)7 (er)12 (ent)19 ( )31 (ALK)11.1 ( mut)7 (ations hav)11.1 (e been described. )]TJ 0.104 Tw 0 -1.294 Td [(Mut)7 (ations )0.5 (in ho)5 (tspo)5 (ts F117)64 (4L)29 ( in e)10 (x)15 (on 23 \()31 (positions 3520 )29.4 (T)29 ( )]TJ /T1_2 1 Tf 0 Tw (\035)Tj /T1_0 1 Tf 0.104 Tw ( C )Tj 0.06 Tw 0 -1.294 Td (and 3522 C )Tj /T1_2 1 Tf 0 Tw (\035)Tj /T1_0 1 Tf 0.06 Tw [( )30.6 (A)34 (\) and R1275Q in e)10 (x)15 (on 25 \()31 (position 3824 G )]TJ /T1_2 1 Tf 0 Tw (\035)Tj /T1_0 1 Tf -0.034 Tc 0.063 Tw [( A\))-34 ( )]TJ 0 Tc 0.061 Tw 0 -1.294 Td [(ac)12 (c)12 (ount)19 ( )13.8 (f)7 (or)24 ( 70% o)6 (f)21 ( all )30.7 (ALK)11 ( mut)7 (ations. U)10 (sing ddPCR, )11.8 (the)9 (y)25 ( hav)11.1 (e )]TJ 0.244 Tw 0 -1.294 Td [(been det)7 (ect)7 (ed in 21.62% o)6 (f)21 ( patients included in a study)25 ( b)11 (y)25 ( )]TJ 0.063 Tw 0 -1.294 Td [(Combar)12 (et)19 ( )0.5 (et)]TJ /Span<>> BDC 5.803 0 Td ( )Tj EMC (al)Tj 0 Tw 4.9555 0 0 4.9555 370.0551 371.5753 Tm (42)Tj 0.063 Tw 8.5 0 0 8.5 375.6003 368.7448 Tm [( )24.4 (with a sensitivity)25 ( )0.5 (o)6 (f)21 ( 100%, )0.5 (85%, )0.5 (and 92%, )0.5 (and )]TJ 0 Tw -7.632 -1.294 Td [(speci\032city)25 ( o)6 (f)21 ( 100%, 91%, and 98%, r)12 (espectiv)11 (ely)38 (.)]TJ -0.013 Tw 0 -2.353 Td [(S)5 (tudies perf)7.1 (orming genomic c)12 (op)10.9 (y)25.1 ( number)24 ( pr)12 (o)6 (\032ling using bo)5 (th, )]TJ 0.366 Tw 0 -1.294 Td [(whole-genome sequencing and molecular)24 ( in)8 (v)11 (er)4 (sion pr)12 (obe )]TJ 0.23 Tw 0 -1.294 Td [(assay)38 (, hav)11 (e demonstr)12 (at)7 (ed subst)7 (antial spatial and )12.2 (t)7 (empor)12 (al )]TJ 0.162 Tw 0 -1.294 Td [(het)7 (er)12 (ogeneity)25 ( o)6 (f)21 ( neur)12 (oblast)7 (oma )12.4 (tumor)4 (s. )31.4 (An incr)12.1 (ease in seg)]TJ 0 Tw (-)Tj 0.184 Tw 0 -1.294 Td [(ment)7 (al chr)12.1 (omosomal alt)7 (er)12 (ations o)11 (v)11 (er)24 ( )11.8 (the c)12 (our)4.1 (se o)6 (f)21 ( )11.8 (the dis)]TJ 0 Tw (-)Tj 0.125 Tw 0 -1.294 Td [(ease as )23.6 (w)10 (ell as )11.6 (the emer)12 (genc)12 (e o)6 (f)21 ( ne)7 (w)24 ( somatic mut)7 (ations as )]TJ 0.066 Tw 0 -1.294 Td [(the r)12 (esult)19 ( o)6 (f)21 ( subclonal e)9 (v)11 (olution )23.8 (w)10 (as observ)11 (ed.)]TJ 0 Tw 4.9555 0 0 4.9555 494.633 274.5753 Tm (40)Tj 0.066 Tw 8.5 0 0 8.5 500.5646 271.7448 Tm [( Int)7 (er)12 (estingly)38 (, )]TJ 0.245 Tw -22.334 -1.294 Td [(while )0.5 (most)19 ( alt)7 (er)12 (ations )24.4 (w)10 (er)12 (e observ)11.1 (ed bo)5 (th )0.5 (b)10.9 (y)25.1 ( )12.4 (tumor)24 ( )12.4 (tissue )]TJ 0.005 Tw 0 -1.294 Td [(and cfDNA)31 ( analy)7 (sis )0.5 (\()45.9 (e.g., )0.5 (M)22 (Y)41 (CN, )0.5 (5p gain c)12 (ont)7 (aining )0.5 (IRX1/IRX2, )]TJ 0.259 Tw 0 -1.294 Td [(CCDC148/PKP)34 (4 gain, )30.8 (A)51 (TRX deletion, )30.8 (A)9.9 (UTS2 deletion)41 (\), some )]TJ 0.334 Tw 0 -1.294 Td [(w)10 (er)12 (e only)25.1 ( det)7 (ect)7 (able b)11 (y)25 ( )11.9 (tumor)24 ( )11.9 (tissue \()28.1 (CDKN2A/B, PTPRD)19.1 (, )]TJ 0.217 Tw 0 -1.294 Td [(and 12q )0.5 (deletions)39 (\) or)24 ( )0.5 (cfDNA)31 ( analy)7 (sis \(LIN28B, )0.5 (IGF1R, )29.4 (TER)6 (T\). )]TJ 0.159 Tw 0 -1.294 Td [(Alt)7 (er)12 (ations observ)10.9 (ed solely)25 ( in cfDNA)31 ( )24.1 (w)10 (er)12 (e det)7 (ect)7 (ed at)19 ( lo)9 (w)10 (er)24 ( )]TJ 0 Tw 0 -1.294 Td [(fr)12 (actions )12 (than ct)5 (DNA)31 ( suggesting )12 (their)23.9 ( subclonal origin.)]TJ 4.9555 0 0 4.9555 521.3427 197.5753 Tm [(39)10 (,40)]TJ 0.189 Tw 8.5 0 0 8.5 310.7243 174.7448 Tm [(5-Hy)11 (d)]TJ /Span<>> BDC ( )Tj EMC 2.868 0 Td [(r)12 (o)15 (xym)]TJ /Span<>> BDC ( )Tj EMC 2.837 0 Td [(eth)8 (yl)]TJ /Span<>> BDC ( )Tj EMC 2.208 0 Td [(c)4 (yt)7 (os)]TJ /Span<>> BDC ( )Tj EMC 2.356 0 Td [(ine \()13 (5-hm)7 (C\) is )14.3 (f)7 (ormed as an int)7 (erme)]TJ 0 Tw (-)Tj 0.34 Tw -10.269 -1.294 Td [(diat)7 (e in )11.9 (the pr)12.1 (oc)12 (ess o)6 (f)21 ( c)4 (yt)7 (osine demet)]TJ /Span<>> BDC ( )Tj EMC 19.25 0 Td [(h)8 (ylat)]TJ /Span<>> BDC ( )Tj EMC 2.264 0 Td (ion\227e)Tj /Span<>> BDC ( )Tj EMC 2.741 0 Td (pigen)Tj /Span<>> BDC ( )Tj EMC 2.581 0 Td (etic )Tj 0.137 Tw -26.836 -1.294 Td [(change r)12 (esponsible )14.1 (f)7 (or)24 ( )12.2 (the activ)11 (ation o)6 (f)21 ( gene e)10 (xpr)12 (ession. B)10.9 (y)25.1 ( )]TJ -0.062 Tw 0 -1.294 Td [(c)12 (omparing epigenetic pr)12 (o)6 (\032les o)6 (f)21 ( patients )23.7 (with and )23.6 (without)19 ( clin)]TJ 0 Tw (-)Tj 0.123 Tw 0 -1.294 Td [(ic)12 (al e)9 (videnc)12 (e o)6 (f)21 ( neur)12 (oblast)7 (oma, )31.1 (Applebaum et)]TJ /Span<>> BDC 21.854 0 Td ( )Tj EMC (al)Tj 0 Tw 4.9555 0 0 4.9555 507.0097 133.5753 Tm (43)Tj 0.123 Tw 8.5 0 0 8.5 512.5945 130.7448 Tm ( identi\032ed )Tj 0.156 Tw -23.749 -1.294 Td [(347 genes )11.8 (that)19 ( sho)9 (w)10 (ed signi\032c)12 (antly)25 ( di\031)7 (er)12 (ent)19 ( 5-hm)7 (C aggr)12 (e)]TJ 0 Tw (-)Tj 0.029 Tw 0 -1.294 Td [(gat)7 (es. Utilizing )12 (these \032ndings, )12 (the)9 (y)25 ( managed )11.9 (t)7 (o pr)12 (edict)19 ( met)7.1 (a)]TJ 0 Tw (-)Tj 0.017 Tw 0 -1.294 Td [(st)7 (atic bur)12 (den in a c)12 (ohort)19 ( o)6 (f)21 ( 21 patients )23.6 (with a sensitivity)25 ( o)6 (f)21 ( 70% )]TJ 0.19 Tw 0 -1.294 Td [(and speci\032city)25 ( o)6.1 (f)21 ( 89)10 (.5%, r)12 (espectiv)11 (ely)38 (. M)6 (or)12 (eo)11 (v)11 (er)58 (, )11.6 (the change )]TJ 0.258 Tw 0 -1.294 Td [(in 5-hm)7 (C pr)12 (o)6 (\032les o)11 (v)11 (er)23.9 ( )12.2 (the c)12 (our)4 (se o)6 (f)21 ( )12.2 (the disease r)12 (e\027ect)7.1 (ed )]TJ 0.07 Tw 0 -1.294 Td [(the changes in )12.3 (tumor)24.1 ( bur)12 (den; henc)12 (e, r)12 (eal-)13 (time assessment)19 ( o)5.9 (f)21.1 ( )]TJ -0.038 Tw 0 -1.294 Td [(5-hm)7 (C st)7 (atus in patients su\031)7 (ering )13.8 (fr)12 (om neur)12 (oblast)7 (oma may)25 ( be )]TJ ET q 0 Tw 0 g /GS0 gs 0 TL/Fm1 Do Q BT /T1_1 1 Tf 0 Tw 7 0 0 7 56.6929 21.1059 Tm (246)Tj ET endstream endobj 387 0 obj << /BaseEncoding /WinAnsiEncoding /Differences [24 /scedilla /uniFB03 /uniFB00 /uniFB02 /dotlessi /gbreve /f_j /uniFB01] /Type /Encoding >> endobj 389 0 obj << /Filter /FlateDecode /Length 100745 /Subtype /Type1C >> stream H\W{pTg 4CkKQJyLtIYͲMděݛ݅wBj Vp SVXQ[`:)kGvZZF~9wu8i=Y9X3u'f9.@<ۮ2ߥ+jh 5ǯ?hXM54580LD?P4%R jjTZKCm>#nj80#9u#'6uzJD7 t^K =Fo' ]g#7=> C8}>KF/З idng0L$!&ͬg60)ğ'ŗ39xEFvRKZ%%L&=$=&HGcүҫқy?Yʷ r/ ٔ.y]s7k UnS*w*]ʀV6*%eM٩QT+(Ǖ+[;%*jzڪTFP-uzB}YChjҖhJmPKk9M6iU>+c~vH{ZM~ωϏogzwwďğ??7~f[Zڈi'ފwlK'w1 t]-cNLFtkIؚ`v|ްܼ:b̓^ Pǎ  & Qc6`J1T=}4+CE)CSel2$ILL"A'Ieb~5 e9aXn :cp vBqM$0=k0̰֧S%#a &+ImR*Nb5;#= s@g`dt&ؗj3yP6MZ!&7G=EΒeԈ:jN*ְʆR ;Yr5brAz3 lam@WbL*V{qt7A 0*ڂ@;TC8WtictF΀ʆcTYШDj!f1tEL71dB7JL1nMX K7a1ˎsʨn!ݽ=dޙ*ֶ;ڌ^$*[ji*Pq%ZZp`VƦ{`>JL1ĬΦRmUtg3:%pk5qr&7U0ՒQt +_tt+?#l^5sqKYu2f'` n0"FЉW ,k1*v@7(Q hVV]7+>OREap.z!ugP4iӤZJ,z 1u"¬OfΚ\@upN@ \4 ',630~4rt%$<'cy5?eri+zT@I~$$ D2$d HRHF2$d{ EEIɽHp2K(#yncY텲T7 ‹=b#U׿mys,OqMn?8S@ )ZkXxWBȡTDIBEvMP7Ʊ4m !2!!qEI[rMp'D Mh^Ӹ"mFDF1Pcl0+h`)3;e\| {Cn\+`;T at&a)0E|TK ,{W +[(Gzz>sab?P Up p~ pמpm\֊ chJĨ].tx,O| s>vS,`|1&`+ꈠ`Z=d|m133w@#мBB#4af ŜϓQ BT eWh{B;Z-͂6tsE =mŢk/ƲX^oIHJG $Xkv%a;u#6aS+6{ m1ڀ0BfWd:!s%~.nE5GbE@ 'McP`XO8QS(4F SQyh6\Λ%.kp7vvg]Qj0W'TD#<:l?^Eu f;G[4V)MGͮh-G':@?U)Ig1-ұT,t*rtJ%Hlt;Q})3Hqʐ!o5P1n.Ícx:FFݑeLwO dRz2-3Jdh栄VHz &mMoF/sHDY~$7=(ځ=* Ѷ[Y!vK]eY-rdqoI$Kd,N)I:Aֺ UR>%l [^K0ّ"5+w^kٛ!9֒: `?9T刅r"YNrf,yk9|\p aRG?sr9Y5r3Kn?_䞣ܑҮR.GY)wH)+R% 0y$J$UJ^$o[_y&GO^ȇFA>ޒ(k哝~DVբo6?3zMѴ|i^I4.D~ju-{gӑ}'}ٷ_3P訡R:t b:;0ݣDEjOoKz9MN8 LLN Ld28K!ٜv ap/Ia!#SϹ8wpS˜OqqA:uȝqI/.a=Xw\j#nɤ&rUWS9^\͍ܘTw38SVĴL 35po4^<Љf[żB*x"c'Ot Oo,terg]^^5uyo;97y?ox'wWUƳ̕YQ|ϴ|ѕbl֌b5ֶcX&4_og6JRφlL`c? 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P)6 (r)12 (ogr)12.1 (ess )12 (t)7 (o)9 (w)10 (ar)12 (d )]TJ 0.14 Tw -20.42 -1.333 Td [(liquid biopsies in pediatric solid )11.6 (tumor)4 (s. )]TJ /T1_1 1 Tf [(Canc)13.1 (er)24.7 ( M)6.2 (et)7.5 (ast)7.5 (asis )0.5 (R)21.3 (e)9.1 (v)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0 -1.333 Td [(2019;38\()54 (4)21 (\):553-571. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 7 0 0 7 141.7176 566.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.337 Tw 7.5 0 0 7.5 56.6929 556.5007 Tm (8.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td [(K)19 (ahana-E)13.1 (dwin)]TJ /Span<>> BDC ( )Tj EMC (S, Cain)Tj /Span<>> BDC ( )Tj EMC [(LE, K)19 (arpelo)9 (w)6 (sky)]TJ /Span<>> BDC 19.17 0 Td ( )Tj EMC [(J. R)21 (oadmap )12.3 (t)7 (o liquid )]TJ 0.019 Tw -19.168 -1.333 Td [(biops)8 (y)25 ( )0.5 (biobanking )14.4 (fr)12 (om )0.5 (pediatric )0.5 (c)12 (anc)12 (er)4 (s-challenges )0.5 (and oppor)]TJ 0 Tw 29.517 0 Td (-)Tj -29.517 -1.333 Td (tunities. )Tj /T1_1 1 Tf 0.052 Tw 3.838 0 Td [(Biopr)13.4 (eser)1.2 (v )0.5 (Biobank)]TJ /T1_0 1 Tf 8.943 0 Td [(. 2021;19\(2\):124-)20 (129)10 (. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 238.3212 536.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.063 Tw 7.5 0 0 7.5 56.6929 526.5007 Tm [(9)10 (.)]TJ /Span<>> BDC ( )Tj EMC 2.267 0 Td [(V)47 (ellichir)12 (ammal)]TJ /Span<>> BDC ( )Tj EMC [(NN, Chaturv)11 (edi)]TJ /Span<>> BDC ( )Tj EMC [(NK, J)10 (oshi)]TJ /Span<>> BDC ( )Tj EMC [(SS, Coult)7 (er)]TJ /Span<>> BDC 23.727 0 Td ( )Tj EMC [(D)12 (W)54 (, Guda)]TJ /Span<>> BDC ( )Tj EMC (C. )Tj 0.087 Tw -23.726 -1.333 Td [(F)32 (usion genes as biomark)29 (er)4 (s in pediatric c)12 (anc)12 (er)4 (s: a r)12 (e)9 (vie)7 (w)23.9 ( o)6 (f)21 ( )12.1 (the )]TJ 0.232 Tw 0 -1.333 Td [(curr)12 (ent)19.1 ( st)7 (at)7 (e and applic)12 (ability)25 ( in diagnostic)5 (s and per)4 (sonaliz)5 (ed )]TJ 0 Tw 0 -1.333 Td [(ther)12 (ap)11 (y)38 (. )]TJ /T1_1 1 Tf 0.052 Tw 4.106 0 Td [(Canc)12.7 (er)24.7 ( L)10.1 (ett)]TJ /T1_0 1 Tf 5.291 0 Td (. 2021;499:24-38. )Tj 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 204.97 496.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.051 Tw 7.5 0 0 7.5 56.6929 486.5007 Tm (10.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td [(S)5 (undb)11 (y)]TJ /Span<>> BDC 3.39 0 Td ( )Tj EMC [(R)6 (T)58 (, P)18 (an)]TJ /Span<>> BDC ( )Tj EMC 4.044 0 Td (A, Shern)Tj /Span<>> BDC ( )Tj EMC [(JF)71.1 (. Liquid biopsies in pediatric onc)12.1 (ology: )]TJ 0.071 Tw -7.433 -1.333 Td [(opportunities and obst)7 (acles. )]TJ /T1_1 1 Tf [(Curr)25.7 ( O)5 (pin )0.6 (P)18.1 (ediatr)]TJ /T1_0 1 Tf 21.596 0 Td [(. 2022;34\(1\):39-47)80 (. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 73.7009 466.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.064 Tw 7.5 0 0 7.5 56.6929 456.5007 Tm (11.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td [(v)11 (an P)18 (aemel)]TJ /Span<>> BDC ( )Tj EMC [(R, )30.7 (Vlug)]TJ /Span<>> BDC ( )Tj EMC [(R, de P)6 (r)12 (et)7 (er)]TJ /Span<>> BDC 14.71 0 Td ( )Tj EMC (K, et)Tj /Span<>> BDC 2.349 0 Td ( )Tj EMC [(al. )28.6 (The pitf)7 (alls and pr)12 (omise )]TJ 0.039 Tw -17.058 -1.333 Td [(o)6 (f)21 ( )0.5 (liquid )0.5 (biopsies )14.4 (f)7 (or)23.9 ( )0.5 (diagnosing and )12.5 (tr)12 (eating )0.5 (solid )12.5 (tumor)4 (s )0.5 (in chil)]TJ 0 Tw (-)Tj 0.052 Tw 0 -1.333 Td [(dr)12 (en: a r)12 (e)9 (vie)7 (w)33 (. )]TJ /T1_1 1 Tf [(E)13.2 (ur)24.9 ( J )0.6 (P)18.1 (ediatr)]TJ /T1_0 1 Tf 12.904 0 Td [(. 2020;179\(2\):191-)14 (202. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 245.4731 436.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.186 Tw 7.5 0 0 7.5 56.6929 426.5007 Tm (12.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td [(Geor)12 (ge)]TJ /Span<>> BDC ( )Tj EMC [(SL, I)6 (z)5 (quier)12 (do)]TJ /Span<>> BDC ( )Tj EMC (E, Campbell)Tj /Span<>> BDC ( )Tj EMC (J, et)Tj /Span<>> BDC 18.421 0 Td ( )Tj EMC [(al. )30.9 (A)31 ( )12 (t)7 (ailor)12 (ed molecular)24 ( )]TJ 0.056 Tw -18.42 -1.333 Td [(pr)12 (o)6 (\032ling pr)12 (ogr)12 (amme )13.7 (f)7 (or)24 ( childr)12 (en )23.7 (with c)12 (anc)12 (er)24 ( )11.7 (t)7 (o identify)25 ( clinic)12 (ally)25 ( )]TJ 0.326 Tw 0 -1.333 Td [(actionable genetic alt)7 (er)12 (ations. )]TJ /T1_1 1 Tf [(E)13.2 (ur)24.9 ( J )0.6 (Canc)13.1 (er)]TJ /T1_0 1 Tf 21.372 0 Td [(. 2019;121:224-)14 (235. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 73.7009 396.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.217 Tw 7.5 0 0 7.5 56.6929 386.5007 Tm (13.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td (Krumbholz)Tj /Span<>> BDC ( )Tj EMC [(M, H)10 (ellber)12 (g)]TJ /Span<>> BDC ( )Tj EMC [(J, S)5 (t)7 (eif)]TJ /Span<>> BDC 14.481 0 Td ( )Tj EMC (B, et)Tj /Span<>> BDC 2.704 0 Td ( )Tj EMC [(al. Genomic EW)6 (SR1 )13.8 (fusion )]TJ 0.102 Tw -17.184 -1.333 Td [(sequenc)12 (e as highly)25 ( sensitiv)11 (e and dynamic plasma )11.9 (tumor)24 ( mark)29 (er)24 ( )]TJ 0.546 Tw 0 -1.333 Td [(in E)17 (wing sar)12 (c)12 (oma. )]TJ /T1_1 1 Tf [(Clin )1.5 (Canc)13 (er)24.8 ( )0.5 (R)21.3 (es)]TJ /T1_0 1 Tf (. 2016;22\(17\):4356-4365. )Tj 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 73.7009 356.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.056 Tw 7.5 0 0 7.5 56.6929 346.5007 Tm (14.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td (Shulman)Tj /Span<>> BDC ( )Tj EMC (DS, Klega)Tj /Span<>> BDC ( )Tj EMC [(K, Imamo)11 (vic)21.1 (-)54.9 (T)92.1 (uc)12 (o)]TJ /Span<>> BDC ( )Tj EMC 17.565 0 Td (A, et)Tj /Span<>> BDC 2.083 0 Td ( )Tj EMC [(al. Det)7 (ection o)6 (f)21 ( cir)12 (cu)]TJ 0 Tw (-)Tj 0.11 Tw -19.646 -1.333 Td [(lating )12 (tumour)24 ( DNA)31 ( is associat)7 (ed )24 (with inf)7 (erior)24 ( out)7 (c)12 (omes in E)17 (wing )]TJ 0.081 Tw 0 -1.333 Td [(sar)12 (c)12 (oma )0.5 (and ost)7 (eosar)12.1 (c)12 (oma: a )0.5 (r)12 (eport)19 ( )14.5 (fr)12 (om )12.4 (the )0.5 (Childr)12 (en)14 (\222)24 (s )0.5 (O)5 (nc)12 (ol)]TJ 0 Tw (-)Tj 0.052 Tw 0 -1.333 Td [(ogy)25 ( Gr)12 (oup. )]TJ /T1_1 1 Tf [(Br)24.4 ( J )0.5 (Ca)0.6 (nc)12.5 (er)]TJ /T1_0 1 Tf 10.663 0 Td [(. 2018;119\()13 (5\):615-621. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 225.626 316.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.052 Tw 7.5 0 0 7.5 56.6929 306.5007 Tm (15. Bodlak)Tj /Span<>> BDC ( )Tj EMC 4.933 0 Td (A, Chang)Tj /Span<>> BDC ( )Tj EMC (K, Channel)Tj /Span<>> BDC ( )Tj EMC (J, et)Tj /Span<>> BDC 11.549 0 Td ( )Tj EMC [(al. Cir)12 (culating plasma )12 (tumor)24 ( DNA)31 ( )]TJ 0.276 Tw -14.214 -1.333 Td [(is superior)24 ( )11.8 (t)7 (o plasma )11.8 (tumor)24 ( RNA)31 ( det)7 (ection in E)17 (wing sar)12.1 (c)12 (oma )]TJ 0.363 Tw 0 -1.333 Td [(patients: p)5 (t)5 (DNA)31 ( and p)5 (t)5 (RNA)31 ( in E)17 (wing sar)12 (c)12 (oma. )]TJ /T1_1 1 Tf [(J )0.9 (M)6.3 (ol )1.4 (D)5.3 (iagn)]TJ /T1_0 1 Tf 0 Tw 29.737 0 Td (. )Tj -29.737 -1.333 Td (2021;23\(7\):872-881. )Tj 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 7 0 0 7 141.2375 276.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.136 Tw 7.5 0 0 7.5 56.6929 266.5007 Tm (16. Shah)Tj /Span<>> BDC ( )Tj EMC 4.262 0 Td [(A)51 (T)58 (, )31.2 (Az)5 (ad)]TJ /Span<>> BDC ( )Tj EMC 4.459 0 Td [(TD)19 (, Br)12 (eese)]TJ /Span<>> BDC ( )Tj EMC (MR, et)Tj /Span<>> BDC 8.51 0 Td ( )Tj EMC [(al. )31.1 (A)31 ( c)12 (ompr)12 (ehensiv)11 (e cir)12 (culating )]TJ 0.026 Tw -14.963 -1.333 Td [(tumor)24 ( DNA)31.1 ( assay)25 ( )13.8 (f)7 (or)24 ( det)7 (ection o)6 (f)21 ( )11.9 (tr)12 (ansloc)12 (ation and c)12 (op)10.9 (y)14.1 (-number)24 ( )]TJ -0.073 Tw 0 -1.333 Td [(changes in pediatric sar)12 (c)12 (omas. )]TJ /T1_1 1 Tf -0.102 Tw [(M)6.3 (ol )-28.3 (Canc)12.7 (er)24.7 ( Ther)]TJ /T1_0 1 Tf -0.073 Tw 21.72 0 Td [(. 2021;20\(10)21 (\):2016-)]TJ 0 Tw -21.72 -1.333 Td (2025. )Tj 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 7 0 0 7 94.708 236.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.052 Tw 7.5 0 0 7.5 56.6929 226.5007 Tm [(17)80 (.)]TJ /Span<>> BDC ( )Tj EMC 2.267 0 Td [(L)60 (y)7 (skj\346r)]TJ /Span<>> BDC 3.45 0 Td ( )Tj EMC [(I, K)19 (ar)12 (a)]TJ /Span<>> BDC ( )Tj EMC [(N, de N)10 (oon)]TJ /Span<>> BDC ( )Tj EMC (S, et)Tj /Span<>> BDC 10.36 0 Td ( )Tj EMC [(al. Ost)7 (eosar)12 (c)12 (oma: no)11 (v)11 (el pr)12 (ognostic )]TJ -0.009 Tw -13.809 -1.333 Td [(biomark)29 (er)4 (s using cir)12 (culating and c)12 (ell-)16 (fr)12 (ee )11.7 (tumour)24 ( DNA. )]TJ /T1_1 1 Tf [(E)13.2 (ur)24.9 ( J Can)]TJ 0 Tw 29.517 0 Td (-)Tj -0.012 Tc 0.012 Tw -29.517 -1.333 Td [(c)0.5 (e)-11.7 (r)]TJ /T1_0 1 Tf 0 Tc 0.052 Tw 1.45 0 Td [(. 2022;168:1-)20 (11. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 135.6856 206.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.05 Tw 7.5 0 0 7.5 56.6929 196.5007 Tm (18.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td [(T)91 (ombolan)]TJ /Span<>> BDC ( )Tj EMC [(L, R)21 (ossi)]TJ /Span<>> BDC ( )Tj EMC (E, Binatti)Tj /Span<>> BDC ( )Tj EMC 12.878 0 Td (A, et)Tj /Span<>> BDC 2.077 0 Td ( )Tj EMC [(al. Clinic)12 (al signi\032c)12 (anc)12 (e o)6.1 (f)21 ( cir)12 (cu)]TJ 0 Tw (-)Tj 0.105 Tw -14.954 -1.333 Td [(lating )12.1 (tumor)24 ( c)12 (ells and c)12 (ell-)16 (fr)12 (ee DNA)31 ( in pediatric rhabdom)8 (y)11 (osar)]TJ 0 Tw 29.517 0 Td (-)Tj -29.517 -1.333 Td [(c)12 (oma. )]TJ /T1_1 1 Tf 0.052 Tw 3.15 0 Td [(M)6.3 (ol )0.6 (O)5 (nc)12.4 (ol)]TJ /T1_0 1 Tf [(. 2022;16\(10)21 (\):2071-)14.1 (2085. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 216.5038 176.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.036 Tw 7.5 0 0 7.5 56.6929 166.5007 Tm [(19)10 (.)]TJ /Span<>> BDC ( )Tj EMC 2.267 0 Td [(T)91 (ombolan)]TJ /Span<>> BDC ( )Tj EMC (L, Zin)Tj /Span<>> BDC ( )Tj EMC 7.533 0 Td (A, Bisogno)Tj /Span<>> BDC ( )Tj EMC [(G)9 (. Cell-)16 (fr)12.1 (ee DNA)31 ( in pediatric rhabdo)]TJ 0 Tw (-)Tj 0.58 Tw -7.532 -1.333 Td [(m)8 (y)11 (osar)12 (c)12 (oma: po)5 (t)7 (ential and challenges. )]TJ /T1_1 1 Tf 0.579 Tw [(M)6.3 (ethods )1.8 (M)6.3 (ol )0.8 (Biol)]TJ /T1_0 1 Tf 0 Tw 29.737 0 Td (. )Tj -29.737 -1.333 Td [(2019;1909:165-)20 (175. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 7 0 0 7 137.8178 146.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.079 Tw 7.5 0 0 7.5 56.6929 136.5007 Tm (20.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td [(K)19 (o)5 (thari)]TJ /Span<>> BDC ( )Tj EMC [(P)75 (, M)6 (ar)12 (ass)]TJ /Span<>> BDC ( )Tj EMC [(F)71 (, )40.1 (Y)107 (ang)]TJ /Span<>> BDC ( )Tj EMC (JL, et)Tj /Span<>> BDC 14.401 0 Td ( )Tj EMC [(al. Cell-)16 (fr)12 (ee DNA)31 ( pr)12 (o)6 (\032ling in r)12.1 (et)]TJ 0 Tw 15.117 0 Td (-)Tj 0.449 Tw -29.517 -1.333 Td [(inoblast)7 (oma patients )24 (with adv)11 (anc)12 (ed intr)12 (aocular)24 ( disease: an )]TJ 0.007 Tw 0 -1.333 Td [(MSK)39 (CC e)10 (xperienc)12 (e. )]TJ /T1_1 1 Tf [(Canc)13.1 (er)24.7 ( )0.5 (M)6.3 (ed)]TJ /T1_0 1 Tf 14.879 0 Td (. 2020;9\(17\):6093-6101. )Tj 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 264.7469 116.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.206 Tw 7.5 0 0 7.5 56.6929 106.5007 Tm (21.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td [(P)18 (olski)]TJ /Span<>> BDC ( )Tj EMC 3.028 0 Td [(A, X)18 (u)]TJ /Span<>> BDC ( )Tj EMC [(L, P)6 (r)12 (abak)29 (ar)]TJ /Span<>> BDC 8.487 0 Td ( )Tj EMC (RK, et)Tj /Span<>> BDC 3.252 0 Td ( )Tj EMC [(al. )30.7 (V)47 (ariability)25 ( in r)12 (etinoblast)7 (oma )]TJ -0.02 Tw -14.766 -1.333 Td [(genome st)7 (ability)25 ( is driv)11 (en b)11 (y)25 ( age and no)5 (t)19 ( herit)7 (ability)38 (. )]TJ /T1_1 1 Tf [(Genes )0.9 (Chr)13.5 (o)]TJ 0 Tw (-)Tj 0.052 Tw 0 -1.333 Td [(mosomes )1.7 (Canc)13.1 (er)]TJ /T1_0 1 Tf 7.971 0 Td [(. 2020;59\(10)21 (\):584-590. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 213.4652 86.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.058 Tw 7.5 0 0 7.5 56.6929 76.5007 Tm (22.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td (Berry)Tj /Span<>> BDC 2.458 0 Td ( )Tj EMC 0.318 0 Td [(JL, )0.5 (X)18 (u)]TJ /Span<>> BDC ( )Tj EMC 2.827 0 Td [(L, )0.5 (Murphr)12 (ee)]TJ /Span<>> BDC ( )Tj EMC 5.931 0 Td [(AL, )0.5 (et)]TJ /Span<>> BDC 2.58 0 Td ( )Tj EMC 0.318 0 Td [(al. )0.5 (P)18 (o)5 (t)7 (ential )0.5 (o)6 (f)21 ( )0.5 (aqueous humor)24 ( )0.5 (as )]TJ 0.111 Tw -14.43 -1.333 Td [(a surr)12 (ogat)7 (e )11.9 (tumor)24 ( biops)8 (y)25 ( )13.9 (f)7 (or)24 ( r)12 (etinoblast)7 (oma. )]TJ /T1_1 1 Tf [(JAMA)32.3 ( O)4.9 (phthalmol)]TJ /T1_0 1 Tf 0 Tw 29.737 0 Td (. )Tj -29.737 -1.333 Td [(2017;135\(11\):1221-)20 (1230. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 7 0 0 7 149.7724 56.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.131 Tw 7.5 0 0 7.5 310.7244 706.5007 Tm (23.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td (Berry)Tj /Span<>> BDC 2.458 0 Td ( )Tj EMC [(JL, X)18 (u)]TJ /Span<>> BDC ( )Tj EMC [(L, K)19 (ooi)]TJ /Span<>> BDC ( )Tj EMC (I, et)Tj /Span<>> BDC 8.65 0 Td ( )Tj EMC [(al. Genomic cfDNA)31 ( analy)7 (sis o)6 (f)21 ( aqueous )]TJ 0.346 Tw -11.107 -1.333 Td [(humor)24 ( in r)12 (etinoblast)7 (oma pr)12.1 (edicts e)9 (y)11 (e salv)11 (age: )11.9 (the surr)12 (ogat)7 (e )]TJ -0.004 Tw 0 -1.333 Td [(tumor)24 ( biops)8 (y)25 ( )13.8 (f)7 (or)24 ( r)12 (etinoblast)7 (oma. )]TJ /T1_1 1 Tf [(M)6.3 (ol)0.7 ( Canc)13.1 (er)24.7 ( R)21.3 (es)]TJ /T1_0 1 Tf (. 2018;16\(11\):1701-)Tj 0 Tw 0 -1.333 Td (1712. )Tj 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 7 0 0 7 345.0047 676.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.097 Tw 7.5 0 0 7.5 310.7244 666.5007 Tm (24.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td [(X)18 (u)]TJ /Span<>> BDC ( )Tj EMC [(L, P)18 (olski)]TJ /Span<>> BDC ( )Tj EMC 5.543 0 Td [(A, P)6 (r)12 (abak)29 (ar)]TJ /Span<>> BDC 5.534 0 Td ( )Tj EMC (RK, et)Tj /Span<>> BDC 3.032 0 Td ( )Tj EMC [(al. Chr)12 (omosome 6p ampli\032c)12 (ation )]TJ -0.003 Tw -14.108 -1.333 Td [(in aqueous humor)24 ( c)12 (ell-)16 (fr)12.1 (ee DNA)31 ( is a pr)12 (ognostic biomark)29 (er)24 ( )14 (f)7 (or)24 ( r)12 (et)]TJ 0 Tw 29.517 0 Td (-)Tj -0.001 Tw -29.517 -1.333 Td [(inoblast)7 (oma ocular)24 ( surviv)11 (al. )]TJ /T1_1 1 Tf [(M)6.2 (ol )0.6 (Canc)13 (er)24.8 ( R)21.4 (es)]TJ /T1_0 1 Tf [(. 2020;18\()24 (8)24 (\):1166-)20 (1175. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 327.7324 636.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.072 Tw 7.5 0 0 7.5 310.7244 626.5007 Tm (25.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td (Berry)Tj /Span<>> BDC 2.458 0 Td ( )Tj EMC [(JL, X)18 (u)]TJ /Span<>> BDC ( )Tj EMC [(L, P)18 (olski)]TJ /Span<>> BDC ( )Tj EMC 7.167 0 Td (A, et)Tj /Span<>> BDC 2.099 0 Td ( )Tj EMC [(al. )30.7 (A)8 (queous humor)24 ( is superior)24 ( )11.8 (t)7 (o blood )]TJ 0.903 Tw -11.723 -1.333 Td [(as a liquid biops)8 (y)25 ( )14.1 (f)7 (or)24 ( r)12 (etinoblast)7 (oma. )]TJ /T1_1 1 Tf 0 Tw [(O)4.9 (phthalmology)]TJ /T1_0 1 Tf 29.737 0 Td (. )Tj -29.737 -1.333 Td [(2020;127\()54 (4)21 (\):552-554. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 7 0 0 7 401.9066 606.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.035 Tw 7.5 0 0 7.5 310.7244 596.5007 Tm (26.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td (Jim\351nez)Tj /Span<>> BDC ( )Tj EMC [(I, F)36 (r)12 (ouin)]TJ /Span<>> BDC ( )Tj EMC [(\311, Chic)12 (ar)12 (d)]TJ /Span<>> BDC ( )Tj EMC (M, et)Tj /Span<>> BDC 14.78 0 Td ( )Tj EMC [(al. M)6 (olecular)24 ( diagnosis o)6 (f)21 ( r)12 (etino)]TJ 0 Tw (-)Tj 0.468 Tw -14.779 -1.333 Td [(blast)7 (oma b)11 (y)25 ( cir)12 (culating )12.1 (tumor)24 ( DNA)31 ( analy)7 (sis. )]TJ /T1_1 1 Tf [(E)13.3 (ur)24.8 ( )0.7 (J )0.9 (Canc)13.1 (er)]TJ /T1_0 1 Tf 0 Tw 29.737 0 Td (. )Tj -29.737 -1.333 Td [(2021;154:277)49.1 (-)13.9 (287)79.9 (. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 7 0 0 7 388.9544 576.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.045 Tw 7.5 0 0 7.5 310.7244 566.5007 Tm [(27)80 (.)]TJ /Span<>> BDC ( )Tj EMC 2.267 0 Td [(T)91 (ang)]TJ /Span<>> BDC ( )Tj EMC [(K, Gar)12 (dner)]TJ /Span<>> BDC 7.56 0 Td ( )Tj EMC [(S, S)6 (nuderl)]TJ /Span<>> BDC ( )Tj EMC [(M. )29.3 (The r)12 (ole o)6 (f)21.1 ( liquid biopsies in pedi)]TJ 0 Tw (-)Tj -0.013 Tw -7.559 -1.333 Td [(atric )-12.3 (br)12 (ain tumor)4 (s. )]TJ /T1_1 1 Tf -0.001 Tw 8.713 0 Td [(J N)10.1 (eur)13.5 (opathol )2.1 (Exp N)10.1 (eur)13.5 (ol)]TJ /T1_0 1 Tf 11.428 0 Td [(. 2020;79\()12.1 (9)20 (\):934-940. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 327.7324 546.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.017 Tw 7.5 0 0 7.5 310.7244 536.5007 Tm (28.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td [(S)5 (un)]TJ /Span<>> BDC ( )Tj EMC 1.896 0 Td [(Y)75 (, Li)]TJ /Span<>> BDC ( )Tj EMC [(M, R)21 (en)]TJ /Span<>> BDC ( )Tj EMC (S, et)Tj /Span<>> BDC 7.363 0 Td ( )Tj EMC [(al. Exploring genetic alt)7 (er)12 (ations in cir)12.1 (culating )]TJ -0.041 Tw -9.258 -1.333 Td [(tumor)24 ( DNA)31 ( )13.6 (fr)12.1 (om c)12 (er)12 (ebr)12 (ospinal \027uid o)6 (f)21 ( pediatric medulloblast)7 (oma. )]TJ /T1_1 1 Tf 0.052 Tw 0 -1.333 Td [(Sci )1.1 (R)21.3 (ep)]TJ /T1_0 1 Tf 3.4 0 Td (. 2021;11\(1\):5638. )Tj 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 410.5848 516.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.227 Tw 7.5 0 0 7.5 310.7244 506.5007 Tm [(29)10 (.)]TJ /Span<>> BDC ( )Tj EMC 2.267 0 Td (Li)Tj /Span<>> BDC ( )Tj EMC (J, Zhao)Tj /Span<>> BDC ( )Tj EMC [(S, L)10 (ee)]TJ /Span<>> BDC ( )Tj EMC (M, et)Tj /Span<>> BDC 11.025 0 Td ( )Tj EMC [(al. R)21 (eliable )11.8 (tumor)24 ( det)7 (ection b)11 (y)25 ( )23.8 (whole-)]TJ -0.005 Tw -11.024 -1.333 Td [(genome meth)8 (ylation sequencing o)6 (f)21 ( c)12 (ell-)16 (fr)12.1 (ee DNA)31 ( in c)12 (er)12 (ebr)12 (ospinal )]TJ -0.018 Tw 0 -1.333 Td [(\027uid o)6 (f)21 ( pediatric medulloblast)7 (oma. )]TJ /T1_1 1 Tf -0.049 Tw [(Sci A)8.3 (dv)]TJ /T1_0 1 Tf -0.018 Tw [(. 2020;6\()54 (42\):eabb5427)80 (. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 327.7324 476.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.058 Tw 7.5 0 0 7.5 310.7244 466.5007 Tm (30.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td [(P)18 (ag\350s)]TJ /Span<>> BDC ( )Tj EMC [(MDS, R)21 (o)5 (t)7 (em)]TJ /Span<>> BDC ( )Tj EMC [(D)19 (, Gy)11 (dush)]TJ /Span<>> BDC ( )Tj EMC [(G)9 (, et)]TJ /Span<>> BDC 16.41 0 Td ( )Tj EMC [(al. Liquid biops)8 (y)25.1 ( det)7 (ection o)6 (f)21 ( )]TJ 0.071 Tw -16.409 -1.333 Td [(genomic )0.5 (alt)7 (er)12 (ations )0.5 (in )0.5 (pediatric )0.5 (br)12 (ain )12.4 (tumor)4 (s )14.4 (fr)12 (om )0.5 (c)12 (ell-)16 (fr)12 (ee DNA)31.1 ( )]TJ -0.015 Tw 0 -1.333 Td [(in )0.5 (peripher)12 (al )0.5 (blood, )0.6 (CSF)71 (, )0.5 (and )0.5 (urine. )]TJ /T1_1 1 Tf 16.278 0 Td [(N)10.2 (eur)13.2 (o )1.1 (O)5 (nc)12.5 (ol)]TJ /T1_0 1 Tf 5.671 0 Td [(. )0.5 (2022;24\()24 (8)24 (\):1352-)]TJ 0 Tw -21.949 -1.333 Td (1363. )Tj 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 7 0 0 7 346.767 436.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.098 Tw 7.5 0 0 7.5 310.7244 426.5007 Tm (31.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td [(Bruz)5 (ek)]TJ /Span<>> BDC ( )Tj EMC 3.467 0 Td [(AK, R)21 (avi)]TJ /Span<>> BDC ( )Tj EMC (K, Muruganand)Tj /Span<>> BDC ( )Tj EMC 11.705 0 Td (A, et)Tj /Span<>> BDC 2.125 0 Td ( )Tj EMC [(al. E)5 (lectr)12 (onic DNA)31 ( analy)7 (sis )]TJ 0.309 Tw -17.297 -1.333 Td [(o)6 (f)21 ( CSF)24 ( c)12 (ell-)16 (fr)12 (ee )12.1 (tumor)24 ( DNA)31 ( )12.1 (t)7 (o quantify)25 ( multi-gene molecular)24 ( )]TJ 0.51 Tw 0 -1.333 Td [(r)12 (esponse in pediatric high-gr)12.1 (ade glioma. )]TJ /T1_1 1 Tf 0.509 Tw [(Clin )0.8 (Canc)13.1 (er)24.7 ( R)21.4 (es)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0 -1.333 Td [(2020;26\(23)17.1 (\):6266-627)10 (6. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 7 0 0 7 410.899 396.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.095 Tw 7.5 0 0 7.5 310.7244 386.5007 Tm (32.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td (Li)Tj /Span<>> BDC ( )Tj EMC [(D)19 (, Bonner)]TJ /Span<>> BDC 5.669 0 Td ( )Tj EMC [(ER, )31.8 (Wierzbicki)]TJ /Span<>> BDC ( )Tj EMC (K, et)Tj /Span<>> BDC 9.235 0 Td ( )Tj EMC [(al. S)5 (t)7 (andar)12.1 (diz)5 (ation o)6 (f)21 ( )11.8 (the liquid )]TJ 0.059 Tw -14.904 -1.333 Td [(biops)8 (y)25 ( )13.9 (f)7 (or)24 ( pediatric di\031use midline glioma using ddPCR. )]TJ /T1_1 1 Tf [(Sci )0.9 (R)21.4 (ep)]TJ /T1_0 1 Tf 0 Tw (. )Tj -0 -1.333 Td (2021;11\(1\):5098. )Tj 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 7 0 0 7 381.2666 366.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.043 Tw 7.5 0 0 7.5 310.7243 356.5007 Tm (33.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td [(S)5 (t)7 (allar)12 (d)]TJ /Span<>> BDC ( )Tj EMC [(S, Sav)11 (elie\031)]TJ /Span<>> BDC ( )Tj EMC [(MG)9 (, )32.4 (Wierzbicki)]TJ /Span<>> BDC ( )Tj EMC (K, et)Tj /Span<>> BDC 18.539 0 Td ( )Tj EMC [(al. CSF)24 ( H3F3A)31 ( K27M )0.5 (cir)]TJ 0 Tw 10.979 0 Td (-)Tj 0.05 Tw -29.517 -1.333 Td [(culating )12.2 (tumor)24 ( DNA)31.1 ( c)12 (op)11 (y)25 ( number)24 ( quanti\032es )12.1 (tumor)24 ( gr)12 (o)9 (wth and in )]TJ -0.065 Tw 0 -1.333 Td [(vitr)12 (o tr)12 (eatment)19 ( )-12 (r)12 (esponse. )]TJ /T1_1 1 Tf -0.053 Tw 11.557 0 Td [(A)8.3 (ct)7.5 (a N)10.2 (eur)13.5 (opathol )2.3 (Commun)]TJ /T1_0 1 Tf 12.343 0 Td (. 2018;6\(1\):80. )Tj 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 327.7323 326.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.005 Tw 7.5 0 0 7.5 310.7243 316.5007 Tm (34.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td [(Cant)7 (or)]TJ /Span<>> BDC 3.129 0 Td ( )Tj EMC 0.264 0 Td [(E, )32.6 (Wierzbicki)]TJ /Span<>> BDC ( )Tj EMC 6.025 0 Td [(K, )29.6 (T)91 (ar)12 (apor)12 (e)]TJ /Span<>> BDC ( )Tj EMC 5.546 0 Td [(RS, )0.6 (et)]TJ /Span<>> BDC 2.578 0 Td ( )Tj EMC 0.264 0 Td [(al. )0.6 (Serial )0.6 (H3K27M )0.6 (c)12 (ell-)16 (fr)12 (ee )]TJ -0.081 Tw -17.806 -1.333 Td [(tumor)24 ( DNA)31 ( \()46 (cf)22 (-)13 (t)5 (DNA)34 (\) )12 (tr)12 (acking pr)12 (edicts ONC201 )12 (tr)12 (eatment)19 ( r)12 (esponse )]TJ 0.661 Tw 0 -1.333 Td [(and pr)12.1 (ogr)12 (ession in di\031use midline glioma. )]TJ /T1_1 1 Tf 0.66 Tw [(N)10.1 (eur)13.5 (o O)5 (nc)12.5 (ol)]TJ /T1_0 1 Tf 0 Tw 29.737 0 Td (. )Tj -29.737 -1.333 Td [(2022;24\()24 (8)24 (\):1366-)20 (137)64 (4. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 7 0 0 7 403.1066 286.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.105 Tw 7.5 0 0 7.5 310.7243 276.5007 Tm (35.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td (Mueller)Tj /Span<>> BDC 3.465 0 Td ( )Tj EMC 0.365 0 Td [(S, )0.5 (J)10 (ain)]TJ /Span<>> BDC ( )Tj EMC [(P)75.1 (, Liang)]TJ /Span<>> BDC ( )Tj EMC 7.255 0 Td [(W)6 (S, )0.5 (et)]TJ /Span<>> BDC 2.955 0 Td ( )Tj EMC 0.365 0 Td [(al. )31.4 (A)31.1 ( pilo)5 (t)19 ( )0.5 (pr)12 (ecision )0.5 (medicine )12.5 (trial )]TJ 0.308 Tw -14.403 -1.333 Td [(f)7 (or)24 ( childr)12 (en )23.8 (with di\031use intrinsic pontine glioma-PNOC003: a )]TJ 0.041 Tw 0 -1.333 Td [(r)12 (eport)19 ( )14.3 (fr)12 (om )12.3 (the P)18 (aci\032c P)18 (ediatric N)10 (eur)12 (o-O)5 (nc)12 (ology)25 ( Consortium. )]TJ /T1_1 1 Tf 0 Tw [(Int)19.7 ( )]TJ 0.052 Tw 0 -1.333 Td [(J )0.5 (Canc)13.1 (er)]TJ /T1_0 1 Tf 3.9 0 Td [(. 2019;145\(7\):1889-)20 (1901. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 437.851 246.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.141 Tw 7.5 0 0 7.5 310.7243 236.5007 Tm (36.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td [(S)5 (u)]TJ /Span<>> BDC ( )Tj EMC 1.491 0 Td [(Y)75 (, )32.2 (W)47.1 (ang)]TJ /Span<>> BDC ( )Tj EMC (L, Jiang)Tj /Span<>> BDC ( )Tj EMC (C, et)Tj /Span<>> BDC 10.288 0 Td ( )Tj EMC [(al. Incr)12 (eased plasma c)12 (onc)12 (entr)12.1 (ation o)6 (f)21 ( )]TJ 0.063 Tw -11.777 -1.333 Td [(c)12 (ell-)16 (fr)12 (ee DNA)31 ( pr)12 (ec)12 (edes disease r)12 (ecurr)12 (enc)12 (e in childr)12 (en )23.6 (with high-)]TJ 0.052 Tw 0 -1.333 Td [(risk neur)12 (oblast)7 (oma. )]TJ /T1_1 1 Tf [(BMC )1.2 (Canc)13 (er)]TJ /T1_0 1 Tf 15.273 0 Td (. 2020;20\(1\):102. )Tj 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 499.5106 216.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.117 Tw 7.5 0 0 7.5 310.7243 206.5007 Tm [(37)80 (.)]TJ /Span<>> BDC ( )Tj EMC 2.267 0 Td [(S)5 (u)]TJ /Span<>> BDC ( )Tj EMC 1.467 0 Td [(Y)75 (, )32 (W)47 (ang)]TJ /Span<>> BDC ( )Tj EMC [(L, )32 (W)47 (ang)]TJ /Span<>> BDC ( )Tj EMC (X, et)Tj /Span<>> BDC 10.4 0 Td ( )Tj EMC [(al. Dynamic alt)7 (er)12 (ations o)6 (f)21 ( plasma c)12 (ell )]TJ -0.012 Tw -11.866 -1.333 Td [(fr)12 (ee DNA)31 ( in r)12 (esponse )11.7 (t)7 (o chemo)5 (ther)12.1 (ap)11 (y)25 ( in childr)12 (en )23.6 (with neur)12 (oblas)]TJ 0 Tw (-)Tj 0 -1.333 Td [(t)7 (oma. )]TJ /T1_1 1 Tf 0.052 Tw 2.971 0 Td [(Can)0.6 (c)12.5 (er)24.7 ( M)6.2 (ed)]TJ /T1_0 1 Tf 5.69 0 Td [(. 2019;8\()54 (4)21 (\):1558-)20 (1566. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 467.9524 186.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.008 Tw 7.5 0 0 7.5 310.7243 176.5007 Tm (38.)Tj /Span<>> BDC ( )Tj EMC 2.267 0 Td [(I)10 (ehar)12 (a)]TJ /Span<>> BDC ( )Tj EMC 3.237 0 Td [(T)58 (, )39.8 (Y)107 (agyu)]TJ /Span<>> BDC ( )Tj EMC [(S, Go)5 (t)7 (oh)]TJ /Span<>> BDC ( )Tj EMC 8.162 0 Td [(T)58 (, et)]TJ /Span<>> BDC 1.884 0 Td ( )Tj EMC [(al. )30.8 (A)31 ( pr)12 (ospectiv)11 (e e)8.9 (v)11.1 (aluation o)6 (f)21 ( liquid )]TJ 0.543 Tw -13.282 -1.333 Td [(biops)8 (y)25 ( )14 (f)7 (or)24 ( det)7 (ecting M)22 (Y)41 (CN ampli\032c)12 (ation in neur)12 (oblast)6.9 (oma )]TJ 0 Tw 0 -1.333 Td (patients. )Tj /T1_1 1 Tf 0.052 Tw 4.255 0 Td [(Jpn J )0.6 (Clin )1.3 (O)5 (nc)12.5 (ol)]TJ /T1_0 1 Tf 7.073 0 Td [(. 2019;49\()24 (8)24 (\):7)64 (43-)21 (7)64 (48. )]TJ 0.016 0.953 0.894 0.004 k /GS0 gs /T1_2 1 Tf 0 Tw 7 0 0 7 486.156 156.5007 Tm [([Cr)18 (ossRef])]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.21 Tw 7.5 0 0 7.5 310.7243 146.5007 Tm [(39)10 (.)]TJ /Span<>> BDC ( )Tj EMC 2.267 0 Td [(V)47 (an R)21 (o)11 (y)]TJ /Span<>> BDC 3.81 0 Td ( )Tj EMC [(N, )24.7 (v)11 (an der)24 ( Linden)]TJ /Span<>> BDC ( )Tj EMC [(M, M)6 (ent)7 (en)]TJ /Span<>> BDC ( )Tj EMC (B, et)Tj /Span<>> BDC 17.351 0 Td ( )Tj EMC [(al. 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