Naslov
Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all- cause mortality in SARS-CoV-2 patients

Autori
Salai, Grgur ; Vrazic, Hrvoje ; Kovacevic, Ivona ; Janes, Linda Malnar ; Marasovic, Ivan ; Ranilovic, Darjan ; Vukoja, Damir ; Zelenika Margeta, Marina ; Huljev–Sipos, Ivana ; Lalic, Kristina ; Spoljaric, Marko ; Tekavec-Trkanjec, Jasna ; Vergles, Mirna ; Lucijanic, Marko ; Luksic, Ivica ; Ljubicic, Divo

Izvornik
Wiener klinische Wochenschrift (0043-5325) (2023), 2023 Apr 24; 1-9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Asthma ; COVID-19 ; Chronic obstructive pulmonary disease ; Eosinophils ; Retrospective cohort study.

Sažetak
Introduction: The impact of asthma and chronic obstructive pulmonary disease (COPD) in the setting of severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) infection is not clearly defined. Blood eosinophil count is a standard diagnostic test which, according to the previously published literature, might have a potential prognostic role on mortality in patients with SARS-CoV‑2 infection. Aim: To investigate the potential prognostic value of peripheral blood eosinophil count on all-cause mortality of patients hospitalized with SARS-CoV‑2 infection, as well as to assess the impact of asthma or COPD premorbidity on all-cause mortality. Material and methods: We conducted a retrospective registry-based cohort study. Survival analysis was performed by employing the Cox proportional hazards regression model at 30 days of follow-up. Prognostic value of eosinophil count on all-cause mortality was assessed using receiver-operating characteristic (ROC) curve analysis. Results: A total of 5653 participants were included in the study. Our model did not reveal that pre-existing asthma or COPD is a statistically significant covariate for all-cause mortality but, indicated that higher eosinophil count at admission might have a protective effect (hazard ratio, HR 0.13 (95% confidence interval, CI 0.06-0.27), p = 0.0001). ROC curve analysis indicates cut-off value of 20 cells/mm3 (81% specificity ; 30.9% sensitivity). Conclusion: Our results indicate that eosinophil count at hospital admission might have a potential prognostic role for all-cause mortality at 30 days of follow-up ; however this was not demonstrated for pre-existing obstructive lung diseases.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA