N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset

Nemčić, Matej; Tijardović, Marko; Rudman, Najda; Bulum, Tomislav; Tomić, Martina; Plavša, Branimir; Vučković Rebrina, Sandra; Vučić Lovrenčić, Marijana; Duvnjak, Lea; Morahan, Grant; Gornik, Olga

doi:10.1016/j.cca.2023.117298

Pregled bibliografske jedinice broj: 1269153

N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset

Nemčić, Matej; Tijardović, Marko; Rudman, Najda; Bulum, Tomislav; Tomić, Martina; Plavša, Branimir; Vučković Rebrina, Sandra; Vučić Lovrenčić, Marijana; Duvnjak, Lea; Morahan, Grant; Gornik, Olga

N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset // Clinica chimica acta, 543 (2023), 117298, 10 doi:10.1016/j.cca.2023.117298 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1269153 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset

Autori
Nemčić, Matej ; Tijardović, Marko ; Rudman, Najda ; Bulum, Tomislav ; Tomić, Martina ; Plavša, Branimir ; Vučković Rebrina, Sandra ; Vučić Lovrenčić, Marijana ; Duvnjak, Lea ; Morahan, Grant ; Gornik, Olga

Izvornik
Clinica chimica acta (0009-8981) 543 (2023); 117298, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Type 1 diabetes mellitus Serum protein N-glycosylation Diabetes mellitus complications HbA1c Smoking

Sažetak
Objective Previously we have shown that plasma protein N-glycosylation is changed in children at the onset of type 1 diabetes. In this study, we aim to identify N-glycan changes in adults with T1DM, compare them to those in children, and investigate their associations with disease duration, complications, glycaemic status, and smoking. Methods Serum protein N-glycans from 200 adults with type 1 diabetes and 298 healthy controls were analysed using ultra-high performance liquid chromatography and divided into 39 directly measured glycan groups from which 16 derived traits were calculated. Results Compared to healthy controls, subjects with type 1 diabetes showed differences in 19 glycan groups and a decrease in monogalactosylated, an increase in digalactosylated, monosialylated, and antennary fucosylated derived traits, from which changes in monogalactosylation and seven directly measured traits overlapped with previously reported in children. Changes in four directly measured and two derived traits previously seen in children were not detected in adults. HbA1c was positively associated with sialylated and highly branched structures, whereas N-glycome was not influenced by disease duration or diabetic complications. Conclusions Our results suggest potential N-glycome involvement in different stages of type 1 diabetes, including processes underlying its development, the disease itself, as well as those occurring after disease establishment.

Izvorni jezik
Engleski

POVEZANOST RADA

Profili:

Matej Nemčić (autor)