Naslov
Comparison of Androgen Receptor, VEGF, HIF-1, Ki67 and MMP9 Expression between Non-Metastatic and Metastatic Stages in Stromal and Tumor Cells of Oral Squamous Cell Carcinoma
(Comparison of Androgen Receptor, VEGF, HIF-1, Ki67 and MMP9 Expression between Non- Metastatic and Metastatic Stages in Stromal and Tumor Cells of Oral Squamous Cell Carcinoma)

Autori
Batelja-Vuletic, Lovorka ; Tomasovic-Loncaric, Cedna ; Ceppi, Marcello ; Bruzzone, Marco ; Fucic, Aleksandra ; Krstanac, Karolina ; Boras Vucicevic, Vanja

Izvornik
Life (2075-1729) 11 (2021), 4; 336, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
HIF-1 ; Ki67 ; MMP9 ; VEGF ; androgen receptor ; oral squamous cell carcinoma

Sažetak
Objectives: Oral squamous cell carcinoma (OSCC) is the most common oral malignancy with low survival as it is very often diagnosed at an advanced stage, which is why the accurate profiling of the tumor is essential. The aim of this study was to, for the first time, compare in OSCC the frequency of AR, VEGF, MMP9, HiF1beta and Ki67 between the non-metastatic and metastatic disease. Materials and methods: In the study, 96 non- metastatic and 91 metastatic OSCC patients were analysed for AR, VEGF, MMP9, HiF1beta and Ki67 levels by immunohistochemistry. Results: All of the tested biomarkers significantly differed between non-metastatic and metastatic disease. A significant association was found between >/=20% AR positive epithelium cells in cytoplasm, Ki67 and VEGF in cancer stroma. Ki67, HiF1beta, VEGF and MMP9 were significantly associated with TNM stages. Conclusion: Our results show for the first time an interplay between AR, VEGF, MMP9, HiF1beta and Ki67 in OSCC which may contribute to better diagnostics and therapy selection.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
(This article belongs to the Special Issue Androgen
Receptor and AR-Related Signaling in Health and
Disease)

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