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Pregled bibliografske jedinice broj: 1268262

Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia


Nikolac Perkovic, Matea; Borovecki, Fran; Filipcic, Igor; Vuic, Barbara; Milos, Tina; Nedic Erjavec, Gordana; Konjevod, Marcela; Tudor, Lucija; Mimica, Ninoslav; Uzun, Suzana et al.
Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia // Biomolecules, 13 (2023), 3; 570, 14 doi:10.3390/biom13030570 (međunarodna recenzija, članak, znanstveni)


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Naslov
Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia

Autori
Nikolac Perkovic, Matea ; Borovecki, Fran ; Filipcic, Igor ; Vuic, Barbara ; Milos, Tina ; Nedic Erjavec, Gordana ; Konjevod, Marcela ; Tudor, Lucija ; Mimica, Ninoslav ; Uzun, Suzana ; Kozumplik, Oliver ; Svob Strac, Dubravka ; Pivac, Nela

Izvornik
Biomolecules (2218-273X) 13 (2023), 3; 570, 14

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Alzheimer’s disease (AD) ; brain-derived neurotrophic factor (BDNF) ; Clock Drawing test (CDT) ; mild cognitive impairment (MCI) ; Mini-Mental State Examination (MMSE)

Sažetak
In the last decade, increasing evidence has emerged linking alterations in the brain-derived neurotrophic factor (BDNF) expression with the development of Alzheimer’s disease (AD). Because of the important role of BDNF in cognition and its association with AD pathogenesis, the aim of this study was to evaluate the potential difference in plasma BDNF concentrations between subjects with mild cognitive impairment (MCI ; N = 209) and AD patients (N = 295) and to determine the possible association between BDNF plasma levels and the degree of cognitive decline in these individuals. The results showed a significantly higher (p < 0.001) concentration of plasma BDNF in subjects with AD (1.16 ; 0.13–21.34) compared with individuals with MCI (0.68 ; 0.02–19.14). The results of the present study additionally indicated a negative correlation between cognitive functions and BDNF plasma concentrations, suggesting higher BDNF levels in subjects with more pronounced cognitive decline. The correlation analysis revealed a significant negative correlation between BDNF plasma levels and both Mini-Mental State Examination (p < 0.001) and Clock Drawing test (p < 0.001) scores. In conclusion, the results of our study point towards elevated plasma BDNF levels in AD patients compared with MCI subjects, which may be due to the body’s attempt to counteract the early and middle stages of neurodegeneration.

Izvorni jezik
Engleski

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Nikolac Perkovic, Matea; Borovecki, Fran; Filipcic, Igor; Vuic, Barbara; Milos, Tina; Nedic Erjavec, Gordana; Konjevod, Marcela; Tudor, Lucija; Mimica, Ninoslav; Uzun, Suzana et al.
Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia // Biomolecules, 13 (2023), 3; 570, 14 doi:10.3390/biom13030570 (međunarodna recenzija, članak, znanstveni)
Nikolac Perkovic, M., Borovecki, F., Filipcic, I., Vuic, B., Milos, T., Nedic Erjavec, G., Konjevod, M., Tudor, L., Mimica, N. & Uzun, S. (2023) Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia. Biomolecules, 13 (3), 570, 14 doi:10.3390/biom13030570.
@article{article, author = {Nikolac Perkovic, Matea and Borovecki, Fran and Filipcic, Igor and Vuic, Barbara and Milos, Tina and Nedic Erjavec, Gordana and Konjevod, Marcela and Tudor, Lucija and Mimica, Ninoslav and Uzun, Suzana and Kozumplik, Oliver and Svob Strac, Dubravka and Pivac, Nela}, year = {2023}, pages = {14}, DOI = {10.3390/biom13030570}, chapter = {570}, keywords = {Alzheimer’s disease (AD), brain-derived neurotrophic factor (BDNF), Clock Drawing test (CDT), mild cognitive impairment (MCI), Mini-Mental State Examination (MMSE)}, journal = {Biomolecules}, doi = {10.3390/biom13030570}, volume = {13}, number = {3}, issn = {2218-273X}, title = {Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia}, keyword = {Alzheimer’s disease (AD), brain-derived neurotrophic factor (BDNF), Clock Drawing test (CDT), mild cognitive impairment (MCI), Mini-Mental State Examination (MMSE)}, chapternumber = {570} }
@article{article, author = {Nikolac Perkovic, Matea and Borovecki, Fran and Filipcic, Igor and Vuic, Barbara and Milos, Tina and Nedic Erjavec, Gordana and Konjevod, Marcela and Tudor, Lucija and Mimica, Ninoslav and Uzun, Suzana and Kozumplik, Oliver and Svob Strac, Dubravka and Pivac, Nela}, year = {2023}, pages = {14}, DOI = {10.3390/biom13030570}, chapter = {570}, keywords = {Alzheimer’s disease (AD), brain-derived neurotrophic factor (BDNF), Clock Drawing test (CDT), mild cognitive impairment (MCI), Mini-Mental State Examination (MMSE)}, journal = {Biomolecules}, doi = {10.3390/biom13030570}, volume = {13}, number = {3}, issn = {2218-273X}, title = {Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia}, keyword = {Alzheimer’s disease (AD), brain-derived neurotrophic factor (BDNF), Clock Drawing test (CDT), mild cognitive impairment (MCI), Mini-Mental State Examination (MMSE)}, chapternumber = {570} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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