Pregled bibliografske jedinice broj: 1268262
Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia
Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia // Biomolecules, 13 (2023), 3; 570, 14 doi:10.3390/biom13030570 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1268262 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Relationship between Brain-Derived Neurotrophic
Factor and Cognitive Decline in Patients with Mild
Cognitive Impairment and Dementia
Autori
Nikolac Perkovic, Matea ; Borovecki, Fran ; Filipcic, Igor ; Vuic, Barbara ; Milos, Tina ; Nedic Erjavec, Gordana ; Konjevod, Marcela ; Tudor, Lucija ; Mimica, Ninoslav ; Uzun, Suzana ; Kozumplik, Oliver ; Svob Strac, Dubravka ; Pivac, Nela
Izvornik
Biomolecules (2218-273X) 13
(2023), 3;
570, 14
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Alzheimer’s disease (AD) ; brain-derived neurotrophic factor (BDNF) ; Clock Drawing test (CDT) ; mild cognitive impairment (MCI) ; Mini-Mental State Examination (MMSE)
Sažetak
In the last decade, increasing evidence has emerged linking alterations in the brain-derived neurotrophic factor (BDNF) expression with the development of Alzheimer’s disease (AD). Because of the important role of BDNF in cognition and its association with AD pathogenesis, the aim of this study was to evaluate the potential difference in plasma BDNF concentrations between subjects with mild cognitive impairment (MCI ; N = 209) and AD patients (N = 295) and to determine the possible association between BDNF plasma levels and the degree of cognitive decline in these individuals. The results showed a significantly higher (p < 0.001) concentration of plasma BDNF in subjects with AD (1.16 ; 0.13–21.34) compared with individuals with MCI (0.68 ; 0.02–19.14). The results of the present study additionally indicated a negative correlation between cognitive functions and BDNF plasma concentrations, suggesting higher BDNF levels in subjects with more pronounced cognitive decline. The correlation analysis revealed a significant negative correlation between BDNF plasma levels and both Mini-Mental State Examination (p < 0.001) and Clock Drawing test (p < 0.001) scores. In conclusion, the results of our study point towards elevated plasma BDNF levels in AD patients compared with MCI subjects, which may be due to the body’s attempt to counteract the early and middle stages of neurodegeneration.
Izvorni jezik
Engleski
POVEZANOST RADA
Profili:
Oliver Kozumplik
(autor)
Marcela Konjevod
(autor)
Suzana Uzun
(autor)
Dubravka Švob Štrac
(autor)
Lucija Tudor
(autor)
Igor Filipčić
(autor)
Matea Nikolac Perković
(autor)
Ninoslav Mimica
(autor)
Gordana Nedić Erjavec
(autor)
Fran Borovečki
(autor)
Barbara Vuić
(autor)
Nela Pivac
(autor)
Tina Miloš
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE