Pregled bibliografske jedinice broj: 1268255
Selecting solvent systems for spherical crystallization of API
Selecting solvent systems for spherical crystallization of API // 28th Croatian Meeting of Chemists and Chemical Engineers - Book of Abstracts / Rogošić, Marko (ur.).
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023. str. 181-181 (poster, međunarodna recenzija, sažetak, znanstveni)
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Naslov
Selecting solvent systems for spherical
crystallization of API
Autori
Zokić, Iva ; Prlić Kardum, Jasna ; Mužina, Katarina
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
28th Croatian Meeting of Chemists and Chemical Engineers - Book of Abstracts
/ Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023, 181-181
Skup
28th Croatian Meeting of Chemists and Chemical Engineers
Mjesto i datum
Rovinj, Hrvatska, 28.03.2023. - 31.03.2023
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
ceritinib ; solvent system ; spherical crystallization
Sažetak
Spherical crystallization is a particle formation technique in which fine crystalline particles are directly transformed into a spherical shape by simultaneous agglomeration. It is mainly used for particle formation of active pharmaceutical ingredients (APIs) in the pharmaceutical industry. Thus prepared agglomerates have better micrometric properties, flowability and compressibility, which facilitates the process of direct tabletting or coating. [1-3] In this paper, the process of selecting a suitable solvent system for spherical crystallization of ceritinib (CRT), and the effect of the addition of polymer on the formation and properties of agglomerates were investigated. Solubility of ceritinib form A (CRT A) in different organic solvents and water has been determined to select ternary solvent systems consisting of solvent, antisolvent and bridging liquid using Dynochem. The influence of the mixing rate, the amount of solvent in the ternary system and the retention time on the efficiency of the process was investigated. Spherical agglomeration (SA) was carried out in a double-jacketed crystallizer using the saturated solution of CRT A in tetrahydrofuran (solvent) at 35 °C and a mixture of water (antisolvent) and bridging liquid cooled down to 20 °C. The bridging liquid was mixed with water until visible droplets were formed, after which the CRT A solution was added at a constant flow rate using a syringe pump. Quasi-emulsion solvent diffusion (QESD) was carried out by dropwise addition of the saturated CRT A solution into a solution of polymer dissolved in water. The internal structure and size of resulting agglomerates were determined by X-ray diffraction (XRD), Raman spectroscopy and light microscopy, respectively. The agglomerates prepared by QESD are firmer and larger than those prepared by SA. Addition of polymer has not affected the internal structure of agglomerates.
Izvorni jezik
Engleski
Znanstvena područja
Kemijsko inženjerstvo
POVEZANOST RADA
Projekti:
EK-EFRR-KK.01.1.1.07.0017 - Napredno vođenje procesa kristalizacije (CrystAPC) (Bolf, Nenad, EK - KK.01.1.1.07) ( CroRIS)
Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb