Naslov
Correlation between the sex hormone receptors expression and demographic parameters in HNSCC patients

Autori
Čonkaš, Josipa ; Josić, Janja ; Kranjčević, Jacqueline-Katrin ; Piteša, Nikolina ; Kurtović, Matea ; Musani, Vesna ; Sabol, Maja ; Vugrinec, Ozren ; Mumlek, Ivan ; Kvolik Pavić, Ana ; Zubčić, Vedran ; Leović, Dinko ; Ozretić, Petar

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
7th Faculty of Science PhD Student Symposium : Book of Abstracts / Pavlek, Katarina - Zagreb : Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2023, 88-88

ISBN
978-953-6076-01-7

Skup
7th Faculty of Science PhD Student Symposium

Mjesto i datum
Zagreb, Hrvatska, 21.04.2023. - 22.04.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
head and neck squamous cell carcinoma ; HNSCC ; sex hormone receptors

Sažetak
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer globally and has a high mortality rate since it is usually diagnosed in advanced stages [1]. Except for the well-known risk factors such as tobacco and/or alcohol consumption and HPV infection, the gender-specific risk for HNSCC development points to the endocrine microenvironment as another risk factor. In other words, the relative risk for HNSCC development is up to five times higher in males, suggesting either the existence of specific risk factors that affect only males or that females have defensive hormonal and metabolic features as a response to common risk factors [1]. Since some recent studies showed that androgens are significantly associated with poor patient prognosis, we wanted to correlate the sex hormone receptors expression in HNSCC tissue samples with the patient’s age, gender, and primary tumor site. To determine the expression of nuclear (AR, ESR1, ESR2 and PGR) and membrane androgen (SLC39A9, OXER1 and CACNA1C), estrogen (GPER1 and SCN2A), and progesterone (PAQR5, PAQR6, PAQR7, PAQR8, PAQR9, PGRMC1 and PGRMC2) receptors in HNSCC, using the qPCR method, 73 tissue samples of primary HNSCC tumors, 26 metastatic lymph nodes and 22 healthy controls were used. Our results have shown that the mean age at the time of diagnosis was 65 years. Patients older than the median group age have higher expression of the SCN2A gene. Furthermore, 79, 8% of patients were men, and 20, 2% were women. The ESR1 has a lower expression level in women, while expression levels of membrane estrogen receptor SCN2A and progesterone receptor PAQR9 were significantly higher in women. Considering the categorization of head and neck tumors, the largest number of samples belong to oral cavity tumors (33), followed by tumors of the larynx (18), and then the oropharynx (8), hypopharynx (7) and the nasal cavity and paranasal sinuses (7). Interestingly, for both OXER1 and PGR isoform B genes, lower expression in the larynx compared to the metastatic lymph nodes and oral cavity tissue samples was determined.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

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