Naslov
Physicochemical Characterization and Evaluation of Gastrointestinal In Vitro Behavior of Alginate- Based Microbeads with Encapsulated Grape Pomace Extracts.

Autori
Martinović, Josipa ; Lukinac, Jasmina ; Jukić, Marko ; Ambrus, Rita ; Planinić, Mirela ; Šelo, Gordana ; Klarić, Ana-Marija ; Perković, Gabriela ; Bucić-Kojić, Ana

Izvornik
Pharmaceutics (1999-4923) 15 (2023), 3; 980, 28

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
encapsulation ; ionic gelation ; particle characterization ; winery residues ; phenolic compounds ; simulated digestion in vitro

Sažetak
Grape pomace is a byproduct of wineries and a rich source of phenolic compounds that can exert multiple pharmacological effects when consumed and enter the intestine where they can then be absorbed. Phenolic compounds are susceptible to degradation and interaction with other food constituents during digestion, and encapsulation may be a useful technique for protecting phenolic bioactivity and controlling its release. Therefore, the behavior of phenolic-rich grape pomace extracts encapsulated by the ionic gelation method, using a natural coating (sodium alginate, gum arabic, gelatin, and chitosan), was observed during simulated digestion in vitro. The best encapsulation efficiency (69.27%) was obtained with alginate hydrogels. The physicochemical properties of the microbeads were influenced by the coatings used. Scanning electron microscopy showed that drying had the least effect on the surface area of the chitosan-coated microbeads. A structural analysis showed that the structure of the extract changed from crystalline to amorphous after encapsulation. The phenolic compounds were released from the microbeads by Fickian diffusion, which is best described by the Korsmeyer–Peppas model among the four models tested. The obtained results can be used as a predictive tool for the preparation of microbeads containing natural bioactive compounds that could be useful for the development of food supplements.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija, Biotehnologija, Prehrambena tehnologija

Napomena
This article belongs to the Section Drug Delivery
and Controlled Release

POVEZANOST RADA