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Pregled bibliografske jedinice broj: 1267419

Vanadium(IV) complexes of salicylaldehyde-based furoic acid hydrazones: Synthesis, BSA binding and in vivo antidiabetic potential

Zahirović, Adnan; Hadžalić, Selma; Višnjevac, Aleksandar; Fočak, Muhamed; Tüzün, Burak; Žilić, Dijana; Roca, Sunčica; Jurec, Jurica; Topčagić, Anela; Osmanković, Irnesa
Vanadium(IV) complexes of salicylaldehyde-based furoic acid hydrazones: Synthesis, BSA binding and in vivo antidiabetic potential // Journal of inorganic biochemistry, 244 (2023), 112232, 14 doi:10.1016/j.jinorgbio.2023.112232 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1267419 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Vanadium(IV) complexes of salicylaldehyde-based furoic acid hydrazones: Synthesis, BSA binding and in vivo antidiabetic potential

Autori
Zahirović, Adnan ; Hadžalić, Selma ; Višnjevac, Aleksandar ; Fočak, Muhamed ; Tüzün, Burak ; Žilić, Dijana ; Roca, Sunčica ; Jurec, Jurica ; Topčagić, Anela ; Osmanković, Irnesa

Izvornik
Journal of inorganic biochemistry (0162-0134) 244 (2023); 112232, 14

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Vanadium(IV) hydrazone complexes ; Salicylaldehyde ; 2-furoic acid ; BSA binding affinity ; Antidiabetic in vivo potential ; Swiss-ADME analysis

Sažetak
Solution synthesis afforded five novel neutral heteroleptic octahedral paramagnetic mononuclear oxidovanadium(IV) complexes of general composition [VO(bpy)L], where L is a dianionic tridentate ONO- donor hydrazone ligand derived from 2-furoic acid hydrazide and salicylaldehyde and its 5- substituted derivatives. Characterization was carried out by elemental analysis, mass spectrometry, infrared, electron, NMR, and EPR spectroscopy, cyclic voltammetry and conductometry. The molecular and crystal structure of the complex with 5-chloro-salicylaldehyde 2- furoic acid hydrazone (2) was determined. The quantum chemical properties of the vanadium complexes were studied at B3LYP and M062X levels with the lanl2dz basis set using Gaussian. Additionally, Swiss-ADME analysis was performed and complex (4), featuring a 5-nitro substituent on the hydrazone ligand, was selected for further investigation. The effects of the in vivo application of the complex on selected biochemical parameters in healthy and diabetic Wistar rats were investigated. Strong antidiabetic effect associated with moderate hypoalbuminemia was observed. Furthermore, the interaction of complexes with BSA was studied by spectrofluorimetry. A significant conformational change of BSA in the presence of vanadium complexes was found. Synchronous fluorescence spectra revealed significant changes in the tyrosine microenvironment of BSA. The FRET analysis was also used and the non-radiative process of energy transfer is elucidated. Thermodynamic data suggest van der Waals forces and hydrogen bonding as predominant binding modes of complexes to BSA.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija, Biologija



POVEZANOST RADA

Projekti:
HRZZ-IP-2018-01-3168 - Studija važnosti spinskih međudjelovanja kao osnova za nove pristupe u istraživanju materijala (SPES) (Ilakovac-Kveder, Marina, HRZZ - 2018-01) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Jurica Jurec (autor)

Avatar Url Aleksandar Višnjevac (autor)

Avatar Url Dijana Žilić (autor)

Avatar Url Sunčica Roca (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Zahirović, Adnan; Hadžalić, Selma; Višnjevac, Aleksandar; Fočak, Muhamed; Tüzün, Burak; Žilić, Dijana; Roca, Sunčica; Jurec, Jurica; Topčagić, Anela; Osmanković, Irnesa
Vanadium(IV) complexes of salicylaldehyde-based furoic acid hydrazones: Synthesis, BSA binding and in vivo antidiabetic potential // Journal of inorganic biochemistry, 244 (2023), 112232, 14 doi:10.1016/j.jinorgbio.2023.112232 (međunarodna recenzija, članak, znanstveni)
Zahirović, A., Hadžalić, S., Višnjevac, A., Fočak, M., Tüzün, B., Žilić, D., Roca, S., Jurec, J., Topčagić, A. & Osmanković, I. (2023) Vanadium(IV) complexes of salicylaldehyde-based furoic acid hydrazones: Synthesis, BSA binding and in vivo antidiabetic potential. Journal of inorganic biochemistry, 244, 112232, 14 doi:10.1016/j.jinorgbio.2023.112232.
@article{article, author = {Zahirovi\'{c}, Adnan and Had\v{z}ali\'{c}, Selma and Vi\v{s}njevac, Aleksandar and Fo\v{c}ak, Muhamed and T\"{u}z\"{u}n, Burak and \v{Z}ili\'{c}, Dijana and Roca, Sun\v{c}ica and Jurec, Jurica and Top\v{c}agi\'{c}, Anela and Osmankovi\'{c}, Irnesa}, year = {2023}, pages = {14}, DOI = {10.1016/j.jinorgbio.2023.112232}, chapter = {112232}, keywords = {Vanadium(IV) hydrazone complexes, Salicylaldehyde, 2-furoic acid, BSA binding affinity, Antidiabetic in vivo potential, Swiss-ADME analysis}, journal = {Journal of inorganic biochemistry}, doi = {10.1016/j.jinorgbio.2023.112232}, volume = {244}, issn = {0162-0134}, title = {Vanadium(IV) complexes of salicylaldehyde-based furoic acid hydrazones: Synthesis, BSA binding and in vivo antidiabetic potential}, keyword = {Vanadium(IV) hydrazone complexes, Salicylaldehyde, 2-furoic acid, BSA binding affinity, Antidiabetic in vivo potential, Swiss-ADME analysis}, chapternumber = {112232} }
@article{article, author = {Zahirovi\'{c}, Adnan and Had\v{z}ali\'{c}, Selma and Vi\v{s}njevac, Aleksandar and Fo\v{c}ak, Muhamed and T\"{u}z\"{u}n, Burak and \v{Z}ili\'{c}, Dijana and Roca, Sun\v{c}ica and Jurec, Jurica and Top\v{c}agi\'{c}, Anela and Osmankovi\'{c}, Irnesa}, year = {2023}, pages = {14}, DOI = {10.1016/j.jinorgbio.2023.112232}, chapter = {112232}, keywords = {Vanadium(IV) hydrazone complexes, Salicylaldehyde, 2-furoic acid, BSA binding affinity, Antidiabetic in vivo potential, Swiss-ADME analysis}, journal = {Journal of inorganic biochemistry}, doi = {10.1016/j.jinorgbio.2023.112232}, volume = {244}, issn = {0162-0134}, title = {Vanadium(IV) complexes of salicylaldehyde-based furoic acid hydrazones: Synthesis, BSA binding and in vivo antidiabetic potential}, keyword = {Vanadium(IV) hydrazone complexes, Salicylaldehyde, 2-furoic acid, BSA binding affinity, Antidiabetic in vivo potential, Swiss-ADME analysis}, chapternumber = {112232} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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