Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study

Prenc, Ema; Pulanić, Dražen; Pučić-Baković, Maja; Ugrina, Ivo; Desnica, Lana; Milošević, Milan; Pirsl, Filip; Mitchell, Sandra; Rose, Jeremy; Vrhovac, Radovan; Nemet, Damir; Lauc, Gordan; Pavletić, Steven Ž.

doi:10.3389/fimmu.2021.633214

Pregled bibliografske jedinice broj: 1267402

Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study

Prenc, Ema; Pulanić, Dražen; Pučić-Baković, Maja; Ugrina, Ivo; Desnica, Lana; Milošević, Milan; Pirsl, Filip; Mitchell, Sandra; Rose, Jeremy; Vrhovac, Radovan et al.

Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study // Frontiers in Immunology, 12 (2021), 633214, 12 doi:10.3389/fimmu.2021.633214 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1267402 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study

Autori
Prenc, Ema ; Pulanić, Dražen ; Pučić-Baković, Maja ; Ugrina, Ivo ; Desnica, Lana ; Milošević, Milan ; Pirsl, Filip ; Mitchell, Sandra ; Rose, Jeremy ; Vrhovac, Radovan ; Nemet, Damir ; Lauc, Gordan ; Pavletić, Steven Ž.

Izvornik
Frontiers in Immunology (1664-3224) 12 (2021); 633214, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
allogeneic hematopoietic stem cell transplantation ; biomarker ; chronic graft-versus-host disease ; glycans ; immunoglobulin G

Sažetak
Chronic graft-versus-host disease (cGvHD) is a systemic alloimmune and autoimmune disorder and a major late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). The disease is characterized by an altered homeostasis of the humoral immune response. Immunoglobulin G (IgG) glycoprotein is the main effector molecule of the humoral immune response. Changes in IgG glycosylation are associated with a number of autoimmune diseases. IgG glycosylation analysis was done by the means of liquid chromatography in the National Institutes of Health (NIH) cohort of 213 cGvHD patients. The results showed statistically significant differences with regards to cGvHD NIH joint/fascia and skin score, disease activity and intensity of systemic immunosuppression. ROC analysis confirmed that IgG glycosylation increases specificity and sensitivity of models using laboratory parameters and markers of inflammation associated with cGvHD (eosinophil count, complement components C3 and C4 and inflammation markers: albumin, CRP and thrombocyte count). This research shows that IgG glycosylation may play a significant role in cGvHD pathology. Further research could contribute to the understanding of the disease biology and lead to the clinical biomarker development to allow personalized approaches to chronic GvHD therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA

Projekti:
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Ustanove:
Medicinski fakultet, Zagreb,
Nastavni zavod za javno zdravstvo "Dr. Andrija Štampar",
Prirodoslovno-matematički fakultet, Split,
Klinički bolnički centar Zagreb

Profili:

Gordan Lauc (autor)