Pregled bibliografske jedinice broj: 1267394
Synthesis and biological evaluations of ferrocene- pyrimidine hybrids
Synthesis and biological evaluations of ferrocene- pyrimidine hybrids // 28th Croatian Meeting of Chemists and Chemical Engineers, Book of Abstracts / Marko, Rogošić (ur.).
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023. str. 96-96 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1267394 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthesis and biological evaluations of ferrocene-
pyrimidine hybrids
Autori
Lapić, Jasmina ; Kuzman, Ivana ; Frkanec, Ruža ; Frkanec, Leo ; Vrček, Valerije ; Djaković, Senka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
28th Croatian Meeting of Chemists and Chemical Engineers, Book of Abstracts
/ Marko, Rogošić - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023, 96-96
Skup
28th Croatian Meeting of Chemists and Chemical Engineers
Mjesto i datum
Rovinj, Hrvatska, 28.03.2023. - 30.04.2023
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
ferrocene-pyrimidine hybrids
Sažetak
Conjugation of organometallic fragments to a biologically active scaffold has been shown as an excellent strategy for improving the efficacy of drugs and reducing their toxicity. In this regard, ferrocene is a popular choice as bioisosteric group due to its stability and well-understood reactivity and electrochemistry [1]. In the search for bioorganometallic systems with an extended conjugation, our group's previous research has produced new ferrocenyl-nucleobase hybrids with a carbonyl bond between the heterocyclic and organometallic moieties. The synthesis of ferrocenoyl copulates is based on the acylation of nucleobase anions with ferrocenoyl chloride in DMF, where the ferrocenoylation reaction of pyrimidine bases is regiospecific and only the N1 product is formed [2]. However, in the case of purine derivatives, the substituents on the exocyclic amino group of adenine were shown to affect the reactivity of the corresponding purine anion and determine the regioselectivity of the reaction, leading to the formation of N7 and N9 isomers [3].In continuation of the research, a model reaction with uracil was performed to test the reaction regiospecificity in the formation of ferrocene-pyrimidine copulates (Figure 1). After optimizing the reaction conditions, we will focus on investigating the effects of substituents (electron donor or electron acceptor group) at the C-5 position of uracil on the formation of copulates. The position of the substitution in the products will be explored by spectroscopy methods. In order to evaluate the biological potential of synthesized compounds, their influence on specific immune response in mice was tested. The results suggest that examined compounds enhance the production of antigen-specific antibodies and have potential to be used in immune-mediated diseases.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Profili:
Valerije Vrček (autor)
Leo Frkanec (autor)
Ruža Frkanec (autor)
Senka Djaković (autor)
Ivana Kuzmanović (autor)
Jasmina Lapić (autor)