Naslov
Novel 7-chloro-4-aminoquinoline-benzimidazole hybrids as inhibitors of cancer cells growth

Autori
Krstulović, Luka ; Leventić, Marijana ; Glavaš- Obrovac, Ljubica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
28th Croatian Meeting of Chemists and Chemical Engineers (28HSKIKI) / Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023, 94-94

Skup
28th Croatian Meeting of Chemists and Chemical Engineers (28HSKIKI)

Mjesto i datum
Rovinj, Hrvatska, 28.03.2023. - 31.03.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
quinoline, benzimidazole, hybrids

Sažetak
Both benzimidazole and quinoline are found in various biologically active compounds [1, 2]. As a part of our ongoing efforts [3, 4] to prepare novel 7-chloro-4-aminoquinoline hybrid compounds, herein we present synthesis of 23 novel quinoline- benzimidazoles which were evaluated on one non- tumor (MRC-5) and 5 tumor cell lines (HeLa, CaCo- 2, HL-60, THP-1, and HuT78). Results revealed that non-amidine compounds have strong, albeit not selective, antiproliferative activity against all the cell lines, with GI50 ranging from 1 to 10 μM. Cyclopentyl-amidine derivatives, have shown to be more selective with moderate to strong activity against leukemia and lymphoma tumor cell lines.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA