Pregled bibliografske jedinice broj: 1267168
Influence of Mn2+ ion binding on structural changes in metalloregulatory proteins SloR (S. mutans) and ScaR (S. gordonii)
Influence of Mn2+ ion binding on structural changes in metalloregulatory proteins SloR (S. mutans) and ScaR (S. gordonii) // 28HSKIKI : 28th Croatian Meeting of Chemists and Chemical Engineers and 6th Symposium Vladimir Prelog : Book of Abstracts / Rogošić, Marko (ur.).
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023. str. 119-119 (poster, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 1267168 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Influence of Mn2+ ion binding on structural changes in metalloregulatory proteins SloR (S. mutans) and ScaR (S. gordonii)
Autori
Radman, Katarina ; Leščić Ašler, Ivana ; Jelić Matošević, Zoe ; Crnolatac, Ivo ; Piantanida, Ivo ; Bertoša, Branimir
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
28HSKIKI : 28th Croatian Meeting of Chemists and Chemical Engineers and 6th Symposium Vladimir Prelog : Book of Abstracts
/ Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023, 119-119
Skup
28th Croatian Meeting of Chemists and Chemical Engineers
Mjesto i datum
Rovinj, Hrvatska, 28.03.2023. - 31.03.2023
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
manganese ; MD simulations ; Transcriptional factors
Sažetak
Streptococcus gordonii and Streptococcus mutans are oral bacteria that grow as a plaque biofilm on the tooth surface. The metabolic production of hydrogen peroxide produced by S. gordonii can inhibit the growth of S. mutans, the primary causative agent of human dental caries. [1] Manganese ions (Mn2+) are an essential nutrient for pathogenic bacteria and has been linked to virulence in many species. [2] The expression of Mn2+-selective ABC transporters in streptococci is under the regulatory control of a group of homologous metalloregulatory proteins, including ScaR from S. gordonii, and SloR from S. mutans. [3] To investigate the influence of Mn2+ ion binding on structural and dynamical properties of SloR and ScaR, we conducted molecular dynamic simulations of both proteins. The computational results were validated by experimental methods: circular dichrosim (CD) and differential scanning calorimetry (DSC)
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Interdisciplinarne prirodne znanosti
POVEZANOST RADA
Projekti:
HRZZ-IP-2020-02-3446 - Manganovi metalosenzori (MaMes) (Bertoša, Branimir, HRZZ - 2020-02) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb
Profili:
Ivo Piantanida
(autor)
Ivo Crnolatac
(autor)
Branimir Bertoša
(autor)
Katarina Radman
(autor)
Ivana Leščić Ašler
(autor)
Zoe Jelić Matošević
(autor)