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Pregled bibliografske jedinice broj: 1267168

Influence of Mn2+ ion binding on structural changes in metalloregulatory proteins SloR (S. mutans) and ScaR (S. gordonii)


Radman, Katarina; Leščić Ašler, Ivana; Jelić Matošević, Zoe; Crnolatac, Ivo; Piantanida, Ivo; Bertoša, Branimir
Influence of Mn2+ ion binding on structural changes in metalloregulatory proteins SloR (S. mutans) and ScaR (S. gordonii) // 28HSKIKI : 28th Croatian Meeting of Chemists and Chemical Engineers and 6th Symposium Vladimir Prelog : Book of Abstracts / Rogošić, Marko (ur.).
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023. str. 119-119 (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 1267168 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Influence of Mn2+ ion binding on structural changes in metalloregulatory proteins SloR (S. mutans) and ScaR (S. gordonii)

Autori
Radman, Katarina ; Leščić Ašler, Ivana ; Jelić Matošević, Zoe ; Crnolatac, Ivo ; Piantanida, Ivo ; Bertoša, Branimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
28HSKIKI : 28th Croatian Meeting of Chemists and Chemical Engineers and 6th Symposium Vladimir Prelog : Book of Abstracts / Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023, 119-119

Skup
28th Croatian Meeting of Chemists and Chemical Engineers

Mjesto i datum
Rovinj, Hrvatska, 28.03.2023. - 31.03.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
manganese ; MD simulations ; Transcriptional factors

Sažetak
Streptococcus gordonii and Streptococcus mutans are oral bacteria that grow as a plaque biofilm on the tooth surface. The metabolic production of hydrogen peroxide produced by S. gordonii can inhibit the growth of S. mutans, the primary causative agent of human dental caries. [1] Manganese ions (Mn2+) are an essential nutrient for pathogenic bacteria and has been linked to virulence in many species. [2] The expression of Mn2+-selective ABC transporters in streptococci is under the regulatory control of a group of homologous metalloregulatory proteins, including ScaR from S. gordonii, and SloR from S. mutans. [3] To investigate the influence of Mn2+ ion binding on structural and dynamical properties of SloR and ScaR, we conducted molecular dynamic simulations of both proteins. The computational results were validated by experimental methods: circular dichrosim (CD) and differential scanning calorimetry (DSC)

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Interdisciplinarne prirodne znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2020-02-3446 - Manganovi metalosenzori (MaMes) (Bertoša, Branimir, HRZZ - 2020-02) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

28hskiki.org

Citiraj ovu publikaciju:

Radman, Katarina; Leščić Ašler, Ivana; Jelić Matošević, Zoe; Crnolatac, Ivo; Piantanida, Ivo; Bertoša, Branimir
Influence of Mn2+ ion binding on structural changes in metalloregulatory proteins SloR (S. mutans) and ScaR (S. gordonii) // 28HSKIKI : 28th Croatian Meeting of Chemists and Chemical Engineers and 6th Symposium Vladimir Prelog : Book of Abstracts / Rogošić, Marko (ur.).
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023. str. 119-119 (poster, domaća recenzija, sažetak, znanstveni)
Radman, K., Leščić Ašler, I., Jelić Matošević, Z., Crnolatac, I., Piantanida, I. & Bertoša, B. (2023) Influence of Mn2+ ion binding on structural changes in metalloregulatory proteins SloR (S. mutans) and ScaR (S. gordonii). U: Rogošić, M. (ur.)28HSKIKI : 28th Croatian Meeting of Chemists and Chemical Engineers and 6th Symposium Vladimir Prelog : Book of Abstracts.
@article{article, author = {Radman, Katarina and Le\v{s}\v{c}i\'{c} A\v{s}ler, Ivana and Jeli\'{c} Mato\v{s}evi\'{c}, Zoe and Crnolatac, Ivo and Piantanida, Ivo and Berto\v{s}a, Branimir}, editor = {Rogo\v{s}i\'{c}, M.}, year = {2023}, pages = {119-119}, keywords = {manganese, MD simulations, Transcriptional factors}, title = {Influence of Mn2+ ion binding on structural changes in metalloregulatory proteins SloR (S. mutans) and ScaR (S. gordonii)}, keyword = {manganese, MD simulations, Transcriptional factors}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa (HDKI)}, publisherplace = {Rovinj, Hrvatska} }
@article{article, author = {Radman, Katarina and Le\v{s}\v{c}i\'{c} A\v{s}ler, Ivana and Jeli\'{c} Mato\v{s}evi\'{c}, Zoe and Crnolatac, Ivo and Piantanida, Ivo and Berto\v{s}a, Branimir}, editor = {Rogo\v{s}i\'{c}, M.}, year = {2023}, pages = {119-119}, keywords = {manganese, MD simulations, Transcriptional factors}, title = {Influence of Mn2+ ion binding on structural changes in metalloregulatory proteins SloR (S. mutans) and ScaR (S. gordonii)}, keyword = {manganese, MD simulations, Transcriptional factors}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa (HDKI)}, publisherplace = {Rovinj, Hrvatska} }




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