Naslov
Utjecaj kiralnosti leucina na konformaciju i biološku aktivnost ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i leucina
(Influence of leucine chirality on conformational preferences and biological activity of ferrocene dipeptide derived from ferrocene-1,1'-diamine and leucine)

Autori
Tarandek, Ana ; Zovko, Ljiljana ; Cikron, Mirjam ; Mrvčić, Jasna ; Stanzer, Damir ; Roca, Sunčica ; Barišić, Lidija ; Kovačević, Monika

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Influence of leucine chirality on conformational preferences and biological activity of ferrocene dipeptide derived from ferrocene-1, 1'-diamine and leucine / Žižek, Krunoslav ; Katančić, Zvonimir ; Kovačić, Marin - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2022, 143-143

Skup
XIV. susret mladih kemijskih inženjera (SMLKI 2022)

Mjesto i datum
Zagreb, Hrvatska, 24.02.2022. - 25.02.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ferocen ; peptidomimetici ; konformacijska analiza ; antimikrobna aktivnost ; antioksidacijska aktivnost
(ferrocene ; peptidomimetics ; conformational analysis ; antimicrobial activity ; antioxidant activity)

Sažetak
Ferrocene peptides are often used as peptidomimetics because it is known that the conjugation of ferrocene core (Fcd, Fca, Fcda) and different amino acids leads to the formation of intramolecular hydrogen bonds that induce the formation of several elements of secondary structure. [1, 2] Addition of L- or D-leucine to antimicrobial peptide brevinin-1OS can affect improvement of antibacterial and anticancer activity to be ten times stronger than parent peptide. [3] To examine the influence of ferrocene synthone itself, the chirality of leucine (D- / L-) and the influence of protecting groups on the chiral arrangement and biological activity of prepared peptides, we decided to prepare homochiral and heterochiral ferrocene dipeptides Ac-L(D)-Leu-NH- Fn-NH-L(D)-Leu-Boc (1-4). The prepared dipeptides were examined by spectroscopic analysis (IR, NMR, and CD spectroscopy), followed by biological evaluation which included determination of antimicrobial activity (disk-diffusion method and nutrient broth dilution method with determination of MIC values) and determination of antioxidant activity (DPPH and FRAP methods).

Izvorni jezik
Hrvatski

Znanstvena područja
Kemija, Prehrambena tehnologija

POVEZANOST RADA