Naslov
N,N-di(2-picolyl)amine functionalized Amino Acid Based Supramolecular Hydrogels: Synthesis, Characterisation and Potential Biomedical Application

Autori
Čipor, Ivona ; Šišić, Marcela ; Frkanec, Ruža ; Frkanec, Leo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
28HSKIKI : 28th Croatian Meeting of Chemists and Chemical Engineers and 6th Symposium Vladimir Prelog : Book of Abstracts / Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023, 64-64

Skup
28th Croatian Meeting of Chemists and Chemical Engineers (28HSKIKI)

Mjesto i datum
Rovinj, Hrvatska, 28.03.2023. - 31.03.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
supramolecular hydrogels ; self-assembly ; vaccine delivery

Sažetak
Supramolecular hydrogels are soft materials owing their properties to the non-covalent bonding that occurs in self-assembly. These self-assembled materials are often stimuli responsive, reversible, and biocompatible so they are applicable in various fields including biomaterials, tissue engineering, and sensors. Due to these properties, supramolecular hydrogels have also been studied as vaccine delivery systems. In this work, two new supramolecular hydrogels based on amino acids and containing N, N-di(2- picolyl)amine as a pH-sensitive moiety have been synthesized by conventional peptide synthesis methods in solution. The hydrogelation properties of the compounds were determined in water and aqueous buffer solutions. Compound 1 has a minimal gelation concentration (MGC) of 1.5% w/V, while compound 2 shows an MGC of 0.8% w/V. The molecular self-assembly of gels was studied by spectroscopic and microscopic methods such as variable temperature 1H NMR spectroscopy, IR spectroscopy, and transmission electron microscopy to determine the driving force of self-assembly and morphology of these materials. The driving force of self-assembly was determined to be hydrogen bonding and - stacking. The hydrogels were further analyzed for their ability to act as vaccine delivery system. Results show that immunization with the hydrogel-formulated OVA produces higher amounts of OVA-specific antibodies IgG in mice compared to OVA alone, suggesting the immunostimulatory activity of examined hydrogels and their potential in vaccine delivery.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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