Pregled bibliografske jedinice broj: 1266244
The Role of Nitric Oxide in the Micro- and Macrovascular Response to a 7-Day High-Salt Diet in Healthy Individuals
The Role of Nitric Oxide in the Micro- and Macrovascular Response to a 7-Day High-Salt Diet in Healthy Individuals // International journal of molecular sciences, 24 (2023), 8; 7157, 16 doi:10.3390/ijms24087157 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1266244 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The Role of Nitric Oxide in the Micro- and
Macrovascular Response to a 7-Day High-Salt Diet
in Healthy Individuals
Autori
Tolj, Ivana ; Stupin, Ana ; Drenjančević, Ines ; Šušnjara, Petar ; Perić, Leon ; Stupin, Marko
Izvornik
International journal of molecular sciences (1422-0067) 24
(2023), 8;
7157, 16
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
high-salt diet ; endothelium ; nitric oxide ; nitric oxide synthase ; vascular endothelial growth ; microcirculation ; macrocirculation
Sažetak
This study aimed to investigate the specific role of nitric oxide (NO) in micro- and macrovascular response to a 7-day high-salt (HS) diet, specifically by measuring skin microvascular local thermal hyperemia and the flow-mediated dilation of the brachial artery, as well as serum NO and three NO synthase enzyme (NOS) isoform concentrations in healthy individuals. It also aimed to examine the concept of non-osmotic sodium storage in the skin following the HS diet by measuring body fluid status and systemic hemodynamic responses, as well as serum vascular endothelial growth factor C (VEGF-C) concentration. Forty-six young, healthy individuals completed a 7-day low-salt diet, followed by a 7-day HS diet protocol. The 7-day HS diet resulted in impaired NO-mediated endothelial vasodilation in peripheral microcirculation and conduit arteries, in increased eNOS, decreased nNOS, and unchanged iNOS concentration and NO serum level. The HS diet did not change the volume of interstitial fluid, the systemic vascular resistance or the VEGF-C serum level. These results indicate that the 7-day HS-diet induces systemic impairment of NO-mediated endothelial vasodilation, while dissociation in the eNOS and nNOS response indicates complex adaptation of main NO-generating enzyme isoforms to HS intake in healthy individuals. Our results failed to support the concept of non-osmotic sodium storage.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
--IP-2016-06-8744 - Interakcija renin-angiotenzinskog i adrenergičkog sustava u aktivaciji endotela uzrokovanoj oksidativnim stresom (RAS-AdrenOX) (Stupin, Ana) ( CroRIS)
MEFOS--MEFOS-IP-2023-23 - Napredna neinvazivna procjena sustavne hemodinamike i krutosti krvnih žila - implementacija metode impedancijska kardiografija (Stupin, Ana, MEFOS ) ( CroRIS)
Ustanove:
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek
Profili:
Petar Šušnjara
(autor)
Ana Stupin
(autor)
Leon Perić
(autor)
Ines Drenjančević
(autor)
Marko Stupin
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE