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Pregled bibliografske jedinice broj: 1266244

The Role of Nitric Oxide in the Micro- and Macrovascular Response to a 7-Day High-Salt Diet in Healthy Individuals


Tolj, Ivana; Stupin, Ana; Drenjančević, Ines; Šušnjara, Petar; Perić, Leon; Stupin, Marko
The Role of Nitric Oxide in the Micro- and Macrovascular Response to a 7-Day High-Salt Diet in Healthy Individuals // International journal of molecular sciences, 24 (2023), 8; 7157, 16 doi:10.3390/ijms24087157 (međunarodna recenzija, članak, znanstveni)


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Naslov
The Role of Nitric Oxide in the Micro- and Macrovascular Response to a 7-Day High-Salt Diet in Healthy Individuals

Autori
Tolj, Ivana ; Stupin, Ana ; Drenjančević, Ines ; Šušnjara, Petar ; Perić, Leon ; Stupin, Marko

Izvornik
International journal of molecular sciences (1422-0067) 24 (2023), 8; 7157, 16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
high-salt diet ; endothelium ; nitric oxide ; nitric oxide synthase ; vascular endothelial growth ; microcirculation ; macrocirculation

Sažetak
This study aimed to investigate the specific role of nitric oxide (NO) in micro- and macrovascular response to a 7-day high-salt (HS) diet, specifically by measuring skin microvascular local thermal hyperemia and the flow-mediated dilation of the brachial artery, as well as serum NO and three NO synthase enzyme (NOS) isoform concentrations in healthy individuals. It also aimed to examine the concept of non-osmotic sodium storage in the skin following the HS diet by measuring body fluid status and systemic hemodynamic responses, as well as serum vascular endothelial growth factor C (VEGF-C) concentration. Forty-six young, healthy individuals completed a 7-day low-salt diet, followed by a 7-day HS diet protocol. The 7-day HS diet resulted in impaired NO-mediated endothelial vasodilation in peripheral microcirculation and conduit arteries, in increased eNOS, decreased nNOS, and unchanged iNOS concentration and NO serum level. The HS diet did not change the volume of interstitial fluid, the systemic vascular resistance or the VEGF-C serum level. These results indicate that the 7-day HS-diet induces systemic impairment of NO-mediated endothelial vasodilation, while dissociation in the eNOS and nNOS response indicates complex adaptation of main NO-generating enzyme isoforms to HS intake in healthy individuals. Our results failed to support the concept of non-osmotic sodium storage.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
--IP-2016-06-8744 - Interakcija renin-angiotenzinskog i adrenergičkog sustava u aktivaciji endotela uzrokovanoj oksidativnim stresom (RAS-AdrenOX) (Stupin, Ana) ( CroRIS)
MEFOS--MEFOS-IP-2023-23 - Napredna neinvazivna procjena sustavne hemodinamike i krutosti krvnih žila - implementacija metode impedancijska kardiografija (Stupin, Ana, MEFOS ) ( CroRIS)

Ustanove:
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek

Profili:

Avatar Url Petar Šušnjara (autor)

Avatar Url Ana Stupin (autor)

Avatar Url Leon Perić (autor)

Avatar Url Ines Drenjančević (autor)

Avatar Url Marko Stupin (autor)

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Tolj, Ivana; Stupin, Ana; Drenjančević, Ines; Šušnjara, Petar; Perić, Leon; Stupin, Marko
The Role of Nitric Oxide in the Micro- and Macrovascular Response to a 7-Day High-Salt Diet in Healthy Individuals // International journal of molecular sciences, 24 (2023), 8; 7157, 16 doi:10.3390/ijms24087157 (međunarodna recenzija, članak, znanstveni)
Tolj, I., Stupin, A., Drenjančević, I., Šušnjara, P., Perić, L. & Stupin, M. (2023) The Role of Nitric Oxide in the Micro- and Macrovascular Response to a 7-Day High-Salt Diet in Healthy Individuals. International journal of molecular sciences, 24 (8), 7157, 16 doi:10.3390/ijms24087157.
@article{article, author = {Tolj, Ivana and Stupin, Ana and Drenjan\v{c}evi\'{c}, Ines and \v{S}u\v{s}njara, Petar and Peri\'{c}, Leon and Stupin, Marko}, year = {2023}, pages = {16}, DOI = {10.3390/ijms24087157}, chapter = {7157}, keywords = {high-salt diet, endothelium, nitric oxide, nitric oxide synthase, vascular endothelial growth, microcirculation, macrocirculation}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms24087157}, volume = {24}, number = {8}, issn = {1422-0067}, title = {The Role of Nitric Oxide in the Micro- and Macrovascular Response to a 7-Day High-Salt Diet in Healthy Individuals}, keyword = {high-salt diet, endothelium, nitric oxide, nitric oxide synthase, vascular endothelial growth, microcirculation, macrocirculation}, chapternumber = {7157} }
@article{article, author = {Tolj, Ivana and Stupin, Ana and Drenjan\v{c}evi\'{c}, Ines and \v{S}u\v{s}njara, Petar and Peri\'{c}, Leon and Stupin, Marko}, year = {2023}, pages = {16}, DOI = {10.3390/ijms24087157}, chapter = {7157}, keywords = {high-salt diet, endothelium, nitric oxide, nitric oxide synthase, vascular endothelial growth, microcirculation, macrocirculation}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms24087157}, volume = {24}, number = {8}, issn = {1422-0067}, title = {The Role of Nitric Oxide in the Micro- and Macrovascular Response to a 7-Day High-Salt Diet in Healthy Individuals}, keyword = {high-salt diet, endothelium, nitric oxide, nitric oxide synthase, vascular endothelial growth, microcirculation, macrocirculation}, chapternumber = {7157} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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