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Pregled bibliografske jedinice broj: 1266220

Structural, physicochemical and anticancer study of Zn complexes with pyridyl-based thiazolyl-hydrazones

Araškov, Jovana; Maciejewski, Natalia; Olszewski, Mateusz; Višnjevac, Aleksandar; Blagojević, Vladimir; Fernandes, Henrique S.; Sousa, Sérgio F.; Puerta, Adrián; Padrón, José M.; Holló, Berta Barta et al.
Structural, physicochemical and anticancer study of Zn complexes with pyridyl-based thiazolyl-hydrazones // Journal of molecular structure, 1281 (2023), 135157, 8 doi:10.1016/j.molstruc.2023.135157 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1266220 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Structural, physicochemical and anticancer study of Zn complexes with pyridyl-based thiazolyl-hydrazones

Autori
Araškov, Jovana ; Maciejewski, Natalia ; Olszewski, Mateusz ; Višnjevac, Aleksandar ; Blagojević, Vladimir ; Fernandes, Henrique S. ; Sousa, Sérgio F. ; Puerta, Adrián ; Padrón, José M. ; Holló, Berta Barta ; Monge, Miguel ; Rodríguez-Castillo, María ; López-de-Luzuriaga, José M. ; Uğuz, Özlem ; Koca, Atif ; Todorović, Tamara R. ; Filipović, Nenad R.

Izvornik
Journal of molecular structure (0022-2860) 1281 (2023); 135157, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Zn complexes, thyazolyl-hydrazones, X-ray structure
(Zn complexes, thiazolyl-hydrazones, X-ray structure)

Sažetak
Thiazolyl-hydrazones (THs) exhibit a wide spectrum of biological activity that can be enhanced by complexation with various metal ions. Zn(II) complexes with α-pyridine-1, 3-TH ligands may represent an alternative to the standard platinum- based chemotherapeutics. In addition, they show photoluminescence properties and thus can be regarded as multifunctional materials. In this study, we synthesized and characterized three neutral Zn(II) complexes (1–3) with pyridine-based TH ligands HLS1‒3 in order to investigate the influence of the ligands charge on the structure and intermolecular interactions in the solid state, and consequently photophysical properties. The deprotonation of the ligands mainly affects the relative energies of electronic levels in the complexes, compared to cationic counterparts, resulting in similar photoluminescence mechanisms and quantum yields with a small shift in emission energy. The influence of the substitution at the ligands’ periphery on the selected quantum molecular descriptors of the complexes is localized to the substitution site. Also, the substituents did not considerably influence the redox responses of the complexes. However, predominant spectral changes were observed in the course of the first reduction and oxidation processes which caused distinct spectral color changes indicating their possible functionality for electrochromic applications. In addition, complex 1 showed antiproliferative activity with GI50 values below 2 µM on all tested cancer cell lines.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biotehnologija



POVEZANOST RADA

Profili:

Avatar Url Aleksandar Višnjevac (autor)

Poveznice na cjeloviti tekst rada:

doi doi.org

Citiraj ovu publikaciju:

Araškov, Jovana; Maciejewski, Natalia; Olszewski, Mateusz; Višnjevac, Aleksandar; Blagojević, Vladimir; Fernandes, Henrique S.; Sousa, Sérgio F.; Puerta, Adrián; Padrón, José M.; Holló, Berta Barta et al.
Structural, physicochemical and anticancer study of Zn complexes with pyridyl-based thiazolyl-hydrazones // Journal of molecular structure, 1281 (2023), 135157, 8 doi:10.1016/j.molstruc.2023.135157 (međunarodna recenzija, članak, znanstveni)
Araškov, J., Maciejewski, N., Olszewski, M., Višnjevac, A., Blagojević, V., Fernandes, H., Sousa, S., Puerta, A., Padrón, J. & Holló, B. (2023) Structural, physicochemical and anticancer study of Zn complexes with pyridyl-based thiazolyl-hydrazones. Journal of molecular structure, 1281, 135157, 8 doi:10.1016/j.molstruc.2023.135157.
@article{article, author = {Ara\v{s}kov, Jovana and Maciejewski, Natalia and Olszewski, Mateusz and Vi\v{s}njevac, Aleksandar and Blagojevi\'{c}, Vladimir and Fernandes, Henrique S. and Sousa, S\'{e}rgio F. and Puerta, Adri\'{a}n and Padr\'{o}n, Jos\'{e} M. and Holl\'{o}, Berta Barta and Monge, Miguel and Rodr\'{\i}guez-Castillo, Mar\'{\i}a and L\'{o}pez-de-Luzuriaga, Jos\'{e} M. and U\u{g}uz, \"{O}zlem and Koca, Atif and Todorovi\'{c}, Tamara R. and Filipovi\'{c}, Nenad R.}, year = {2023}, pages = {8}, DOI = {10.1016/j.molstruc.2023.135157}, chapter = {135157}, keywords = {Zn complexes, thyazolyl-hydrazones, X-ray structure}, journal = {Journal of molecular structure}, doi = {10.1016/j.molstruc.2023.135157}, volume = {1281}, issn = {0022-2860}, title = {Structural, physicochemical and anticancer study of Zn complexes with pyridyl-based thiazolyl-hydrazones}, keyword = {Zn complexes, thyazolyl-hydrazones, X-ray structure}, chapternumber = {135157} }
@article{article, author = {Ara\v{s}kov, Jovana and Maciejewski, Natalia and Olszewski, Mateusz and Vi\v{s}njevac, Aleksandar and Blagojevi\'{c}, Vladimir and Fernandes, Henrique S. and Sousa, S\'{e}rgio F. and Puerta, Adri\'{a}n and Padr\'{o}n, Jos\'{e} M. and Holl\'{o}, Berta Barta and Monge, Miguel and Rodr\'{\i}guez-Castillo, Mar\'{\i}a and L\'{o}pez-de-Luzuriaga, Jos\'{e} M. and U\u{g}uz, \"{O}zlem and Koca, Atif and Todorovi\'{c}, Tamara R. and Filipovi\'{c}, Nenad R.}, year = {2023}, pages = {8}, DOI = {10.1016/j.molstruc.2023.135157}, chapter = {135157}, keywords = {Zn complexes, thiazolyl-hydrazones, X-ray structure}, journal = {Journal of molecular structure}, doi = {10.1016/j.molstruc.2023.135157}, volume = {1281}, issn = {0022-2860}, title = {Structural, physicochemical and anticancer study of Zn complexes with pyridyl-based thiazolyl-hydrazones}, keyword = {Zn complexes, thiazolyl-hydrazones, X-ray structure}, chapternumber = {135157} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

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