Naslov
Synthesis and biological activity of novel benzazole acrylonitriles

Autori
Beč, Anja ; Persoons, Leentje ; Vanstreels, Els ; Daelemans, Dirk ; Starčević, Kristina ; Hranjec, Marijana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
28th Croatian Meeting of Chemists & Chemical Engineers, Book of Abstracts / Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023, 25-25

Skup
28th Croatian Meeting of Chemists & Chemical Engineers

Mjesto i datum
Rovinj, Hrvatska, 28.03.2023. - 31.03.2023

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
acrylonitriles, benzimidazole, antiproliferative activity, antioxidative activity

Sažetak
The most important benzazole representatives, benzimidazole and benzothiazole derivatives, have been well established as principal structural motifs in medicinal and pharmaceutical chemistry. Acrylonitriles bearing heteroaromatic or aromatic moieties have been recognized as promising biologically active compounds possessing a wide range of biological activities like anticancer, antituberculostatic, antibacterial or antioxidative effects. In this paper, we report the synthesis of novel biologically active methoxy and hydroxy substituted benzimidazole and benzothiazole derivatives, related to 2, 3- disubstituted acrylonitriles. Novel compounds were prepared by classical reactions of organic chemistry and by microwave assisted reactions. Acrylonitrile derivatives bearing benzimidazole nuclei were prepared by aldol condensation of N- substituted 2-cyanomethylbenzimidazoles with corresponding hydroxy subsituted benzaldehydes in moderate to good yields. Acrylonitrile derivatives bearing benzothiazole nuclei were prepared by condensation of 2-benzothiazoleacetonitrile with corresponding methoxy and hydroxy substituted benzaldehydes. All newly prepared compounds will be screened for their antioxidant capacity using several spectroscopic methods as well as antiproliferative activity on several human cancer cells in vitro.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA