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Pregled bibliografske jedinice broj: 1265917

Optimization of the biocatalytic cascade synthesis of (R)-3-hydroxy-γ-butyrolactone by means of kinetic modelling


Ćevid, Ivana; Milčić, Nevena; Majerić Elenkov, Maja; Findrik Blažević, Zvjezdana
Optimization of the biocatalytic cascade synthesis of (R)-3-hydroxy-γ-butyrolactone by means of kinetic modelling // 28HSKIKI : 28th Croatian Meeting of Chemists and Chemical Engineers and 6th Symposium Vladimir Prelog : Book of Abstracts / Rogošić, Marko (ur.).
Zagreb: Hrvatsko kemijsko društvo, 2023. str. 147-147 (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 1265917 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Optimization of the biocatalytic cascade synthesis of (R)-3-hydroxy-γ-butyrolactone by means of kinetic modelling

Autori
Ćevid, Ivana ; Milčić, Nevena ; Majerić Elenkov, Maja ; Findrik Blažević, Zvjezdana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
28HSKIKI : 28th Croatian Meeting of Chemists and Chemical Engineers and 6th Symposium Vladimir Prelog : Book of Abstracts / Rogošić, Marko - Zagreb : Hrvatsko kemijsko društvo, 2023, 147-147

Skup
28th Croatian Meeting of Chemists and Chemical Engineers

Mjesto i datum
Rovinj, Hrvatska, 28.03.2023. - 31.03.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
biocatalysis ; cascade reaction ; HBL ; kinetic modelling

Sažetak
Biocatalysis can be defined as the use of enzymes or whole cells to speed up synthesis reactions. [1] The newer concept in biocatalysis is the synthesis of valuable chemicals achieved through complex cascades with different enzymes sustainably and efficiently. In comparison with conventional chemical processes, cascade reactions offer many advantages like no need for isolation of intermediate products, mild and controlled reaction conditions, simple and economically profitable reaction system which is composed of one reactor. [2] 3-hydroxy-γ-butyrolactone (HBL) is a functional chiral building block with application in the synthesis of different polymers, solvents and pharmaceuticals. With an enzymatic approach, the synthesis of HBL can be economically viable while maintaining the high selectivity of this valuable chemical. [3] In this work, the kinetic model for the cascade reaction (Fig. 1) was developed. Model validation was done by performing the batch reactor experiments. Simulations were used to optimize reaction conditions and choose the best reactor design. References [1] Đ. Vasić-Rački, Z. Findrik, A. Vrsalović Presečki, Appl. Microbiol. Biotechnol. 91 (2011), 845–856. [2] M. Sudar, Z. F. Blažević, Enzyme Cascade Kinetic Modelling, in: S. Kara, F. Rudroff Enzyme Cascade Design and Modelling, Springer International Publishing, Cham, 2021, pp. 91–108. [3] H. Dhamankar, Y. Tarasova, C. H. Martin, K. L. J. Prather, Metab. Eng. 25 (2014) 72-81.

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo, Biotehnologija



POVEZANOST RADA


Projekti:
EK-KK.01.1.1.04.0013 - Inovativna rješenja u katalitičkim proizvodnim procesima za potrebe farmaceutske industrije (CAT PHARMA) (Kirin, Srećko, EK ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Poveznice na cjeloviti tekst rada:

www.hdki.hr

Citiraj ovu publikaciju:

Ćevid, Ivana; Milčić, Nevena; Majerić Elenkov, Maja; Findrik Blažević, Zvjezdana
Optimization of the biocatalytic cascade synthesis of (R)-3-hydroxy-γ-butyrolactone by means of kinetic modelling // 28HSKIKI : 28th Croatian Meeting of Chemists and Chemical Engineers and 6th Symposium Vladimir Prelog : Book of Abstracts / Rogošić, Marko (ur.).
Zagreb: Hrvatsko kemijsko društvo, 2023. str. 147-147 (poster, domaća recenzija, sažetak, znanstveni)
Ćevid, I., Milčić, N., Majerić Elenkov, M. & Findrik Blažević, Z. (2023) Optimization of the biocatalytic cascade synthesis of (R)-3-hydroxy-γ-butyrolactone by means of kinetic modelling. U: Rogošić, M. (ur.)28HSKIKI : 28th Croatian Meeting of Chemists and Chemical Engineers and 6th Symposium Vladimir Prelog : Book of Abstracts.
@article{article, author = {\'{C}evid, Ivana and Mil\v{c}i\'{c}, Nevena and Majeri\'{c} Elenkov, Maja and Findrik Bla\v{z}evi\'{c}, Zvjezdana}, editor = {Rogo\v{s}i\'{c}, M.}, year = {2023}, pages = {147-147}, keywords = {biocatalysis, cascade reaction, HBL, kinetic modelling}, title = {Optimization of the biocatalytic cascade synthesis of (R)-3-hydroxy-γ-butyrolactone by means of kinetic modelling}, keyword = {biocatalysis, cascade reaction, HBL, kinetic modelling}, publisher = {Hrvatsko kemijsko dru\v{s}tvo}, publisherplace = {Rovinj, Hrvatska} }
@article{article, author = {\'{C}evid, Ivana and Mil\v{c}i\'{c}, Nevena and Majeri\'{c} Elenkov, Maja and Findrik Bla\v{z}evi\'{c}, Zvjezdana}, editor = {Rogo\v{s}i\'{c}, M.}, year = {2023}, pages = {147-147}, keywords = {biocatalysis, cascade reaction, HBL, kinetic modelling}, title = {Optimization of the biocatalytic cascade synthesis of (R)-3-hydroxy-γ-butyrolactone by means of kinetic modelling}, keyword = {biocatalysis, cascade reaction, HBL, kinetic modelling}, publisher = {Hrvatsko kemijsko dru\v{s}tvo}, publisherplace = {Rovinj, Hrvatska} }




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