Pregled bibliografske jedinice broj: 1265917
Optimization of the biocatalytic cascade synthesis of (R)-3-hydroxy-γ-butyrolactone by means of kinetic modelling
Optimization of the biocatalytic cascade synthesis of (R)-3-hydroxy-γ-butyrolactone by means of kinetic modelling // 28HSKIKI : 28th Croatian Meeting of Chemists and Chemical Engineers and 6th Symposium Vladimir Prelog : Book of Abstracts / Rogošić, Marko (ur.).
Zagreb: Hrvatsko kemijsko društvo, 2023. str. 147-147 (poster, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 1265917 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Optimization of the biocatalytic cascade synthesis
of (R)-3-hydroxy-γ-butyrolactone by means of kinetic modelling
Autori
Ćevid, Ivana ; Milčić, Nevena ; Majerić Elenkov, Maja ; Findrik Blažević, Zvjezdana
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
28HSKIKI : 28th Croatian Meeting of Chemists and Chemical Engineers and 6th Symposium Vladimir Prelog : Book of Abstracts
/ Rogošić, Marko - Zagreb : Hrvatsko kemijsko društvo, 2023, 147-147
Skup
28th Croatian Meeting of Chemists and Chemical Engineers
Mjesto i datum
Rovinj, Hrvatska, 28.03.2023. - 31.03.2023
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
biocatalysis ; cascade reaction ; HBL ; kinetic modelling
Sažetak
Biocatalysis can be defined as the use of enzymes or whole cells to speed up synthesis reactions. [1] The newer concept in biocatalysis is the synthesis of valuable chemicals achieved through complex cascades with different enzymes sustainably and efficiently. In comparison with conventional chemical processes, cascade reactions offer many advantages like no need for isolation of intermediate products, mild and controlled reaction conditions, simple and economically profitable reaction system which is composed of one reactor. [2] 3-hydroxy-γ-butyrolactone (HBL) is a functional chiral building block with application in the synthesis of different polymers, solvents and pharmaceuticals. With an enzymatic approach, the synthesis of HBL can be economically viable while maintaining the high selectivity of this valuable chemical. [3] In this work, the kinetic model for the cascade reaction (Fig. 1) was developed. Model validation was done by performing the batch reactor experiments. Simulations were used to optimize reaction conditions and choose the best reactor design. References [1] Đ. Vasić-Rački, Z. Findrik, A. Vrsalović Presečki, Appl. Microbiol. Biotechnol. 91 (2011), 845–856. [2] M. Sudar, Z. F. Blažević, Enzyme Cascade Kinetic Modelling, in: S. Kara, F. Rudroff Enzyme Cascade Design and Modelling, Springer International Publishing, Cham, 2021, pp. 91–108. [3] H. Dhamankar, Y. Tarasova, C. H. Martin, K. L. J. Prather, Metab. Eng. 25 (2014) 72-81.
Izvorni jezik
Engleski
Znanstvena područja
Kemijsko inženjerstvo, Biotehnologija
POVEZANOST RADA
Projekti:
EK-KK.01.1.1.04.0013 - Inovativna rješenja u katalitičkim proizvodnim procesima za potrebe farmaceutske industrije (CAT PHARMA) (Kirin, Srećko, EK ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb
Profili:
Maja Majerić Elenkov
(autor)
Ivana Ćevid
(autor)
Zvjezdana Findrik Blažević
(autor)
Nevena Milčić
(autor)