Naslov
Sterigmatocystin – an extraordinary mycotoxin

Autori
Jakšić, Daniela, Šegvić Klarić, Maja ; Šijaković Vujičić, Nataša ; Smrečki, Vilko ; Pescitelli, Gennaro ; Piantanida, Ivo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the international symposium Power of Fungi and Mycotoxins in the Midst of Climate Change (PoFMy), Arhiv za higijenu rada i toksikologiju 73, 4 / - Zagreb, 2022, A25-A25

Skup
Power of Fungi and Mycotoxins in the Midst of Climate Change, International Symposium

Mjesto i datum
Koprivnica, Hrvatska, 16.09.2022. - 17.09.2022

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
aggregate ; hydrophobic interactions ; mycotoxins ; noncovalent interactions ; spectroscopy

Sažetak
Sterigmatocystin (STC) is a polyketide-derived mycotoxin structurally related to aflatoxin B1 (AFB1). Various research pointed to the notable differences in their toxic potencies, biotransformation, and mode of action. Our recent study showed that STC forms a stable aggregate in aqueous solutions in a concentration- dependent manner. Interestingly, none of the sibling molecules, including AFB1 or 5-methoxysterigmatocystin (MET-STC), do not share this property. In addition, the circular dichroism spectrum of exceptionally high intensity yielded from the STC aqueous aggregate had never been documented for any other small molecule. In the presented research it will be demonstrated how this phenomenon can be implemented in the research of STC and why it absolutely must be considered. Special emphasis will be put on the interactions of STC with different biomacromolecules

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA