Pregled bibliografske jedinice broj: 1265572
Ruthenium pyrene complexes: synthesis, characterization and interaction with bovine serum albumin
Ruthenium pyrene complexes: synthesis, characterization and interaction with bovine serum albumin // PBSi 2023 : International Conference On Phosphorus, Boron and Silicon : Book of Abstracts
Berlin, Njemačka: PremC, 2023. str. 29-29 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1265572 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Ruthenium pyrene complexes: synthesis, characterization and interaction with bovine serum albumin
Autori
Opačak Saša ; Pernar Kovač, Margareta ; Brozović, Anamaria ; Piantanida, Ivo ; Kirin, Srećko I.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
PBSi 2023 : International Conference On Phosphorus, Boron and Silicon : Book of Abstracts
/ - : PremC, 2023, 29-29
Skup
International Conference On Phosphorus, Boron and Silicon
Mjesto i datum
Berlin, Njemačka, 22.03.2023. - 24.03.2023
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Ruthenium complexes ; Fluorescence spectroscopy ; Bovine serum albumin
Sažetak
Bovine serum albumin (BSA) is often used as a model protein for human serum albumin, which plays an important role in metabolism.[1] Fluorescence spectroscopy is an attractive method for sensing applications as it is fast, practical, highly sensitive and selective. Ruthenium complexes with organic ligands are widely studied as potential anticancer drugs with some compounds reaching phase II of clinical trials.[2] Continuing our previous work on ruthenium phosphine complexes with anticancer activity, [3] in this paper we describe two ruthenium complexes 1 and 2, both substituted with pyrene – a fluorescent group. Intriguingly, 1 and 2 pyrene emission is completely quenched in water, and mostly reconstituted upon binding to BSA, thus 1 and 2 behaving as switch-on sensors. In addition, the cytotoxicity of the complexes with and without irradiation will be discussed, suggesting their potential use as PTD drugs.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija
POVEZANOST RADA
Projekti:
EK-KK.01.1.1.04.0013 - Inovativna rješenja u katalitičkim proizvodnim procesima za potrebe farmaceutske industrije (CAT PHARMA) (Kirin, Srećko, EK ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Srećko Kirin
(autor)
Saša Opačak
(autor)
Margareta Pernar Kovač
(autor)
Ivo Piantanida
(autor)
Anamaria Brozović
(autor)