Naslov
Applicability of the new solid-state sensor based on functionalized carbon nanomaterials for promethazine hydrochloride determination

Autori
Samardžić, Mirela ; Peršić, Mateja ; Széchenyi, Aleksandar ; Budetić, Mateja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
28th Croatian meeting of chemists & chemical engineers, 6th symposium Vladimir Prelog, Book of abstracts / Rogošić, Marko - Zagreb, 2023, 124-124

Skup
28th Croatian meeting of chemists & chemical engineers, 6th symposium Vladimir Prelog

Mjesto i datum
Rovinj, Hrvatska, 28.03.2023. - 31.03.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
promethazine hydrochloride ; solid-state sensor ; potentiometry

Sažetak
Promethazine hydrochloride (PM) or N, N-dimethyl-1-phenothiazin-10-yl-propan-2-amine hydrochloride has antihistaminic, antiemetic, sedative, antipsychotic, and analgesic properties [1]. It is mainly used to prevent motion sickness or to treat mental illness and allergies [2]. However, it can cause serious adverse effects such as breathing and cardiac problems, endocrine disorders, etc. [3]. Also, in last few decades, its nonmedical abuse has been reported [4]. Considering the wide use of PM, its monitoring is very important. Various analytical methods can be used in that purpose, but many of them require expensive instrumentation, time consuming and complicated procedures, and large amounts of toxic solvents. Potentiometric sensors represent a good alternative considering their selectivity and simplicity. The new potentiometric solid-state sensor had a liquid membrane contained multi-walled carbon nanotubes functionalized with a sulfate group and PM ions as the sensor material, and 2-nitrophenyl phenyl ether as the plasticizer. The applicability of the new sensor for PM determination in pharmaceutical products was investigated using potentiometric titration with sodium tetraphenylborate as the titrant, and the Gran method. The results obtained using both methods were accurate and precise. With daily measurements, the lifetime of the sensor was at least four months.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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