Naslov
Synthesis of novel benzothiazole azo dyes and in vitro biological evaluation of antibacterial and antitumor activity

Autori
Relić, Magda ; Herceg, Mario ; Banjanac, Mihajlo ; Radovanović, Vedrana ; Persoons, Leentje ; Daelemans, Dirk ; Racané, Livio

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
28HSKIKI - Book of Abstracts / Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023, 121-121

Skup
28th Croatian Meeting of Chemists and Chemical Engineers

Mjesto i datum
Rovinj, Hrvatska, 28.03.2023. - 31.03.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Recenziran

Ključne riječi
benzothiazole, azo dyes, biological activity

Sažetak
The study of benzothiazole derivatives became a rapidly developing and increasingly active field due to their interesting pharmacological properties. Benzothiazole analogues offer a high degree of structural diversity, which is useful in the search for new therapeutic agents [1]. On the other hand, aromatic and heteroaromatic azo compounds represent the most numerous and diverse group of synthetic dyes used not only as textile dyes but also in many other industrial fields: for dyeing various substrates, in biomedical research, in the field of nonlinear optics and optical data storage [2]. In conjunction with our previous studies focused on the synthesis and structural investigations of azo-benzothiazole derivatives [3-4], we now turn our attention to the synthesis of novel benzothiazole azo dyes (Figure 1) to evaluate their biological potential. In this work, we presented an efficient method for the synthesis of a small library of 6-azo-substituted benzothiazole molecules by diazotization reactions of 6-amino- substituted benzothiazole derivatives and by copulation of the corresponding diazonium salts with N, N-disubstituted aniline derivatives. In vitro biological evaluations of antibacterial and antitumor activity were performed for a small library of 12 structurally related compounds

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA