Naslov
Bioprospecting of the Adriatic coral Eunicella cavolini

Autori
Matulja, Dario ; Matijević, Gabrijela ; Babić, Sanja ; Grbčić, Petra ; Bojanić, Krunoslav ; Laclef, Sylvain ; Jović, Ozren ; Šmuc, Tomislav ; Car, Iris ; Sedić, Mirela ; Čož-Rakovac, Rozelindra ; Kraljević Pavelić, Sandra ; Marković, Dean

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
28th CROATIAN MEETING OF CHEMISTS & CHEMICAL ENGINEERS / Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023, 101-101

Skup
28th CROATIAN MEETING OF CHEMISTS & CHEMICAL ENGINEERS

Mjesto i datum
Rovinj, Hrvatska, 28.03.2023. - 31.03.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Bioprospecting, Adriatic sea, Eunicella cavolini, natural products

Sažetak
Eunicella cavolini (Koch, 1887) generally recognized as yellow gorgonian, is a species of colonial soft coral in the family Gorgoniidae. Although it is common in the Mediterranean basin, the evaluation of biological potential of E. cavolini from the Adriatic Sea has not been performed yet. Taking this into account, as a part of our Center of excellence for Marine Bioprospecting of Adriatic Sea BioProCro, we have studied the chemical composition and biological activities of this gorgonian. [1] In this contribution, we will discuss the results of screenings of the antiproliferative, antibacterial, antioxidant, and anti-inflammatory activities of organic extracts and corresponding semipurified fractions. Additionally, we will show data concerning antiproliferative activity against four cancer cell lines and one non-transformed cell line, as well as its anti-inflammatory potential concerning the successfully isolated pregnane type steroid by employing dereplication methods. In final, we will present the synthesis of granulatamide B [2] isolated from the coral species of the Eunicella genus and its 12 derivatives by employing Fürstner’s Fe-catalyzed C–C coupling reaction. [3] The obtained small compound library of these N-acyl tryptamines differing in the number of C-atoms, saturation degree and conjugation of double bonds, were evaluated towards the formation and development of zebrafish Danio rerio embryos. [4]

Izvorni jezik
Engleski

POVEZANOST RADA