Naslov
Identification of recently acquired tuberculosis infection using QuantiFERON-TB Gold Plus: an exploratory study

Autori
2. Perez S, Grijota-Camino MD, Sanchez- Montalva A, Barcia L, Campos S, Pomar V, Rabunal- Rey R, Balcells ME, Gazel D, Montiel N, Vicente- Anza D, Goić Barišić I, Schön T, Paues J, Mareković I, Cacho J, Barac A, Goletti D, Garcia- Gasalla M, Barcala JM, Anibarro L, Alcaide F, Pallares N, Tebe C, Santin M

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
30th European Congress of Clinical Microbiology and Infectious Diseases 2020:

Mjesto i datum
Pariz, Francuska, 18.04.2020. - 21.04.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Quantiferon, tuberculosis

Sažetak
We investigated whether the difference of antigen tube 2 (TB2) minus antigen tube 1 (TB1) (TB2-TB1) of the QuantiFERON-TB gold plus test, which has been postulated as a surrogate for the CD8+ T-cell response, could be useful in identifying recent tuberculosis (TB) exposure. We looked at the interferon gamma (IFN-γ) responses and differences in TB2 and TB1 tubes for 686 adults with QFT-plus positive test results. These results were compared among groups with high (368 TB contacts), low (229 patients with immune-mediated inflammatory diseases [IMID]), and indeterminate (89 asylum seekers or people from abroad [ASPFA]) risks of recent TB exposure. A TB2-TB1 value >0.6 IU·ml-1 was deemed to indicate a true difference between tubes. In the whole cohort, 13.6%, 10.9%, and 11.2% of cases had a TB2>TB1 result in the contact, IMID, and ASPFA groups, respectively (P = 0.591). The adjusted odds ratios (aORs) for an association between a TB2-TB1 result of >0.6 IU·ml-1 and risk of recent exposure versus contacts were 0.71 (95% confidence interval [CI], 0.31 to 1.61) for the IMID group and 0.86 (95% CI, 0.49 to 1.52) for the ASPFA group. In TB contact subgroups, 11.4%, 15.4%, and 17.7% with close, frequent, and sporadic contact had a TB2>TB1 result (P = 0.362). The aORs versus the close subgroup were 1.29 (95% CI, 0.63 to 2.62) for the frequent subgroup and 1.55 (95% CI, 0.67 to 3.60) for the sporadic subgroup. A TB2-TB1 difference of >0.6 IU·ml-1 was not associated with increased risk of recent TB exposure, which puts into question the clinical potential as a proxy marker for recently acquired TB infection.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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