Pregled bibliografske jedinice broj: 1264961
Equilibrium and kinetic studies on the reactions of aquapentacyanoferrate(II) with 4-imidazoline-2- thiones
Equilibrium and kinetic studies on the reactions of aquapentacyanoferrate(II) with 4-imidazoline-2- thiones // 28th Croatian Meeting of Chemists and Chemical Engineers: Book of Abstracts / Rogošić, Marko (ur.).
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023. str. 68-68 (poster, domaća recenzija, sažetak, znanstveni)
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Naslov
Equilibrium and kinetic studies on the reactions
of aquapentacyanoferrate(II) with 4-imidazoline-2-
thiones
Autori
Damjanović, Vladimir ; Musija, Danijela ; Picek, Igor ; Foretić, Blaženka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
28th Croatian Meeting of Chemists and Chemical Engineers: Book of Abstracts
/ Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023, 68-68
Skup
28th Croatian Meeting of Chemists and Chemical Engineers
Mjesto i datum
Rovinj, Hrvatska, 28.03.2023. - 31.03.2023
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
pentacyanoferrate(II) complexes ; 4-imidazoline-2-thiones
Sažetak
Heterocyclic compounds based on 4-imidazoline-2- thione are especially important in medicine. They are used as inhibitors of dopamine β-hydroxylase, diuretics, anti-inflammatory and antithyroid drugs. The most commonly used drugs in the treatment of hyperthyroidism are propylthiouracil and two substituted 4-imidazoline-2-thiones, namely, methimazole and carbimazole. In addition, imidazoline-2-thiones serve as precursors in the synthesis of imidazole derivatives and various condensed heterocycles. In the coordination chemistry, imidazoline-2-thiones are important and versatile N, S-donor ligands. In the investigations of reactivity and coordination ability of ambidentate ligands, aquapentacyanoferrate(II) has proven useful. The [Fe(CN)5(OH2)]3–, a structural model of biologically important octahedral iron(II) complexes, undergoes the water–ligand exchange reaction producing corresponding pentacyano(ligand)ferrates(II). The ligand substitution reactions of aquapentacyanoferrate(II) ion with 4-imidazoline- 2-thione (imtH2), 1-methyl-4-imidazoline-2-thione (meimtH, methimazole) or ethyl 3-methyl-2- sulfanylidene-imidazole-1-carboxylate (meimtR, carbimazole) were studied in aqueous solutions. The produced pentacyano(imidazoline-2- thione)ferrates(II) were characterized by UV/Vis and 13C-NMR spectroscopy. The equilibrium constant for the formation of pentacyano(imidazoline-2-thione)ferrate(II) was determined spectrophotometrically. The rate constants and activation parameters for the formation as well as for the dissociation of pentacyano(imidazoline-2-thione)ferrate(II) complexes were determined by UV/Vis spectroscopy. The hydrolysis of free meimtR and meimtR coordinated on [Fe(CN)5]3– moiety was investigated. On the basis of spectroscopic data and kinetic parameters it has been established that 4-imidazoline-2-thiones coordinate to iron(II) through the sulfur atom.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Zagreb
Profili:
Vladimir Damjanović (autor)
Danijela Cvijanović (autor)
Igor Picek (autor)
Blaženka Foretić (autor)