Naslov
Seasonality of polyaromatic hydrocarbons (PAHs) and their derivatives in PM2.5 from Ljubljana, source apportionment, and cytotoxicity of selected nitrated polyaromatic hydrocarbons (NPAHs)

Autori
Ivana Drventić, Mateo Glumac, Ivana Carev, Ana Kroflič

Izvornik
Toxics (2305-6304) 11 (2023), 6; 518-518

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cytotoxicity, PAHs, PM2.5

Sažetak
Airborne particulate matter (PM) is a vector of many toxic pollutants, including polyaromatic hydrocarbons (PAHs) and their derivatives. Especially harmful is the fine fraction (PM2.5), which penetrates deep into the lungs during inhalation and causes various diseases. Amongst PM2 components with toxic potential are nitrated PAHs (NPAHs), knowledge of which is still rudimentary.Three of the measured NPAHs (1- nitropyrene (1-nP), 9-nitroanthracene (9-nA), and 6-nitrochrysene(6-nC)) were detected in ambient PM2.5 from Ljubljana, Slovenia, along with thirteen non-nitrated PAHs. The highest concentrations of pollutants, which are closely linked with incomplete combustion, were observed in the cold part of the year, whereas the concentrations of NPAHs were roughly an order of magnitude lower than those of PAHs throughout the year. Further on, we have evaluated the toxicity of four NPAHs, including 6- nitrobenzo[a]pyrene (6-nBaP), to the human kidney cell line, HEK293T. The most potent was 1-nP (IC50 = 28.7 µM), followed by the other three NPAHs, whose IC50 was above 400 or 800 µM. According to our cytotoxicity assessment, atmospheric 1-nP is the most harmful NPAH among the investigated ones. Despite low airborne concentrations of NPAHs in ambient air, they are generally considered harmful to human health. Therefore, systematic toxicological assessment of NPAHs at different trophic levels, starting with cytotoxicity testing, is necessary in order to accurately evaluate their threat and adopt appropriate abatement strategies.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti, Farmacija

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