Pregled bibliografske jedinice broj: 1264510
Different damaging effects of volatile anaesthetics alone or in combination with 1 and 2 Gy gamma-irradiation in vivo on mouse liver DNA: a preliminary study
Different damaging effects of volatile anaesthetics alone or in combination with 1 and 2 Gy gamma-irradiation in vivo on mouse liver DNA: a preliminary study // Arhiv za higijenu rada i toksikologiju, 74 (2023), 22-33 doi:10.2478/aiht-2023-74-3692 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1264510 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Different damaging effects of volatile
anaesthetics alone or in
combination with 1 and 2 Gy gamma-irradiation in
vivo on mouse
liver DNA: a preliminary study
Autori
Benković, Vesna ; Milić, Mirta ; Oršolić, Nada ; Horvat Knežević, Anica ; Brozović, Grozdana ; Borojević, Nikola
Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 74
(2023);
22-33
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
alkaline comet assay ; halothane ; ionising irradiation ; isoflurane ; sevoflurane
Sažetak
As the number of radiotherapy and radiology diagnostic procedures increases from year to year, so does the use of general volatile anaesthesia (VA). Although considered safe, VA exposure can cause different adverse effects and, in combination with ionising radiation (IR), can also cause synergistic effects. However, little is known about DNA damage incurred by this combination at doses applied in a single radiotherapy treatment. To learn more about it, we assessed DNA damage and repair response in the liver tissue of Swiss albino male mice following exposure to isoflurane (I), sevoflurane (S), or halothane (H) alone or in combination with 1 or 2 Gy irradiation using the comet assay. Samples were taken immediately (0 h) and 2, 6, and 24 h after exposure. Compared to control, the highest DNA damage was found in mice receiving halothane alone or in combination with 1 or 2 Gy IR treatments. Sevoflurane and isoflurane displayed protective effects against 1 Gy IR, while with 2 Gy IR the first adverse effects appeared at 24 h post- exposure. Although VA effects depend on liver metabolism, the detection of unrepaired DNA damage 24 h after combined exposure with 2 Gy IR indicates that we need to look further into the combined effects of VA and IR on genome stability and include a longer time frame than 24 h for single exposure as well as repeated exposure as a more realistic scenario in radiotherapy treatment.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Javno zdravstvo i zdravstvena zaštita, Farmacija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Sveučilište J. J. Strossmayera u Osijeku
Profili:
Nikola Borojević
(autor)
Mirta Milić
(autor)
Vesna Benković
(autor)
Anica Horvat Knežević
(autor)
Nada Oršolić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- Animal Science Database
- Biological Sciences (CSA)
- BIOSIS Previews
- GreenFile
- INIS
- Pollution Abstracts
- Veterinary Science Database
- Water Resources Abstracts
- EBSCO Academic Search Complete
- TEMA
- TOXLINE
- AGRIS
- Food Science and Technology Abstracts – FSTA
- Ergonomic Abstracts