Naslov
Metabolic stability as a challenge facing drug- oriented research

Autori
Žunec, Suzana ; Kopjar, Nevenka ; Bartolić, Marija ; Katalinić, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Arhiv za higijenu rada i toksikologiju / - , 2023

Skup
Arhiv za higijenu rada i toksikologiju

Mjesto i datum
Zagreb, Hrvatska, 26.01.2023

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
NCE, cannabionids, preclinical, small-scale, biotransformation

Sažetak
Drug metabolism studies were previously performed at a late stage of drug development process and very often not until the phase of clinical studies. Therefore, inadequate metabolism and pharmacokinetic parameters frequently presented the major reason of failure for new chemical entities (NCEs). Nowadays, introduction of in vitro approaches into drug metabolism enables the characterization of the metabolic properties of lead candidates at early preclinical studies even in a small-scale academic laboratory. In the framework of the lecture, plans for new perspective testing based on determination of metabolic stability and biotransformation of NCEs with special emphasis on designed cholinesterase-acting compounds will be presented. Using the example of research on interactions between conventional cytostatic and cannabinoids, evidence will be provided to which extent metabolism research is important for better understanding of the biological (pharmacological or therapeutic and/or toxic) effect of a drug. This research was supported by the Croatian Science Foundation UIP-2017-05-7260.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA