Naslov
Where are we going from here?

Autori
Katalinić, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Arhiv za higijenu rada i toksikologiju / - , 2023, A19-A19

Skup
Cell-Based Research in Toxicology and Drug Design

Mjesto i datum
Zagreb, Hrvatska, 26.01.2023

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
cytotoxicity ; cancer ; repurposing ; PAINS ; oximes ; MAO ; nicotinic

Sažetak
Based on the results obtained within the CellToxTargets project, we have set the direction for continuation of the study addressing biological activity perspectives for designed reversible cholinesterase ligands. Namely, we will screen the wider activity of several defined sets of designed cholinesterases’ ligands, that have shown previously in our study to affect cells beyond influencing cholinesterases. With this, we hypothesize identifying compounds with a potential to be developed into drugs for other important therapeutic areas such as diseases affecting multiple cell types (cancer, diabetes, neurodegenerative disorders, muscle diseases etc.). Firstly, we will focus our research on determining to what extent selected compounds alter activity of validated drug targets of choice (like monoamine oxidase, cytochrome enzymes, nicotinic acetylcholine receptor or glucose transporters). Secondly, we will look into the anticancer potential of selected compounds, in example, on prostate and breast cancer cells. Additionally, we will determine the metabolic stability and biotransformation of tested compounds to get the full profile of their potential to be developed into drugs. Within the scope of our future research, we will elucidate whether any of the tested compounds falls into the category of the so-called Pan-Assay Interference Compounds (PAINS), or chemical compounds that often give false positive results in high-throughput screens. Namely, PAINS more likely react nonspecifically with numerous biological targets rather than specifically affecting one desired target, misleading the research and conclusions on the overall biological activity. This research was supported by the Croatian Science Foundation UIP-2017-05-7260.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA