Naslov
Molecular mechanisms underlying the toxicity of antidotes and potential drugs – HRZZ-UIP-2017-05- 7260

Autori
Katalinić, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Arhiv za higijenu rada i toksikologiju / - , 2023, A11-A11

Skup
Cell-Based Research in Toxicology and Drug Design

Mjesto i datum
Zagreb, Hrvatska, 26.01.2023

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
cytotoxicity ; cancer ; apoptotis ; caspase ; oximes ; NRE
(cytotoxicity ; apoptotis ; caspase ; oximes ; NRE)

Sažetak
This lecture will give a brief overview of the CellToxTargets project which started in 2018 bringing the new innovative approach in the field of antidote research for poisoning with the organophosphorus compounds (OP). The project goals were divided into four major outlines: 1. implementation of an adequate cell- based preclinical screening as a cell-based early safety evaluation in antidote discovery and research ; 2. defining the antidote’s effects on cell level and the mechanism of cell chemosensitivity to antidotes in OP poisoning ; 3. defining the possible structural features/moieties of the tested compounds triggering certain effects ; and 4. identifying new possible pharmacological targets on the cell level as well as explore their therapeutic potential. All obtained results proved that we have successfully reached all set goals. When looking at the statistical indicators, during the five project years, we have tested 148 compounds on 10 different cell types, and have implemented 12 new methods in the lab. Until now, overall results were published in 1 book chapter, 13 journal articles and 43 conference abstracts. The project topic has also been addressed in 3 doctoral theses and 4 diploma theses. During the project duration, we had 5 student practices and presented results to general public as well. Furthermore, we have established collaboration with several groups from Croatia as well as from Slovenia, Czech Republic, France and Portugal, helping us reaching our project goals. With the help of our colleagues, we were able to overcome several critical moments triggered by the COVID pandemic, the earthquake damage and the rebuilding of our main Institute. Taken all together, we have obtained a strong background giving us the needed input for further research and continuation of our study focusing on repurposing tested compounds for wider applications in the drug discovery as well. This research was supported by the Croatian Science Foundation UIP-2017-05-7260.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA