Naslov
DIFFERENCES AMONG SUBLINES OF WZ-5HT RATS IN THE EMERGENCE TEST, AUTOGROOMING AND REARING BEHAVIOUR DURING THE OPEN FIELD TEST
(DIFFERENCES AMONG SUBLINES OF WZ-5HT RATS IN THE EMERGENCE TEST, AUTOGROOMING AND REARING BEHAVIOUR DURING THE OPEN FIELD TEST)

Autori
Tvrdeić, Ante ; Poljak, Ljiljana ; Miše, Branko ; Pavić, Josip ; Kesić, Maja ; Čičin-Šain, Lipa

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract Book of 9th Croatian Congress of Pharmacology with International Participation / Šalković-Petrišić, Melita - Zagreb : Hrvatsko društvo farmakologa, 2019, 121-121

Skup
9. hrvatski kongres farmakologije = 9th Croatian Congress of Pharmacology

Mjesto i datum
Zagreb, Hrvatska, 25.09.2019. - 28.09.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
WZ-5HT rat sublines ; behavioural phenotypes ; emergence test ; grooming ; rearing

Sažetak
In several models of anxiety-like behaviour sublines of WZ-5HT rats with extremely low levels of platelet serotonin (low-5HT subline) showed less anxious behaviour than rats with extremely high platelet serotonin (high-5HT subline). To further investigate phenotype differences among WZ-5HT sublines in the domain of anxiety, we compared high-5HT (n=9) with low-5HT male rats (n=15) for a total number of grooming and rearing episodes during 10 minutes of the open field test and for the incidence to appear on rims of the open-top home cage during 5 minutes of the emergence test. Rats were tested in three subsequent sessions. In comparison to high5HT rats, low-5HT rats had a significantly lower number of grooming episodes during all open field test sessions (p<0, 05 unpaired t-test, p<0, 001 and p<0, 0001 Mann-Whitney tests) and a significantly higher number of rearing episodes in last two open field test sessions (p<0, 05 and p<0, 0001, unpaired t-tests). Regarding emergence test, low-5HT rats started to appear on the edges of cages during the first test session (33 %) and continued to emerge during next two sessions (87 % and 100 %, p<0, 0001 and p<0, 001 compared to high-5HT rats, Fisher’s exact tests). At the same time, high-5HT rats just started to appear during the last test session (0 %, 0 % and 55, 5 % for 1st, 2nd and 3rd session, respectively). Results presented here suggest that low-5HT rats had less anxious behaviour and more impulsive, disinhibited temperament as compared to high-5HT rats characterized by timidity, cautious and inhibited temperament

Izvorni jezik
Engleski

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