Naslov
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Autori
Nepogodiev, Dmitri ; ... ; Soljic, Martina ; COVIDSurg Collaborative

Kolaboracija
COVIDSurg Collaborative ; GlobalSurg Collaborative

Izvornik
British journal of surgery (0007-1323) 108 (2021), 9; 1056-1063

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
SARS-CoV-2 ; vaccination ; safe surgery

Sažetak
Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS- CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results: NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351 ; best case 196, worst case 816) or non-cancer surgery (733 ; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840 ; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19- related deaths in 1 year. Conclusion: As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Dissemination Committee (alphabetical by country):
Croatia: Ana Danić Hadžibegović, Tomislav Kopjar,
Jakov Mihanović
Local Collaborators:
Croatia: Kristina Bitunjac, Karlo Grulović,
Marijana
Vučković (General and Veterans Hospital ‘Hrvatski
Ponos’ Knin, Knin); Goran Šantak (County General
Hospital Pozega, Pozega); Emanuel Borovic, Ana
Bosak
Versic, Damir Hasandić, Natasa Poldan Grabar,
Suzana
Srsen Medancic (University Hospital Center Rijeka,
Rijeka); Lucija Brkic, Sara Cokarić, Petra Pavic
Palac,
Zeljka Samac, Josipa Tomić, Marija Vrdoljak
(General
Hospital Sibenik, Sibenik); Ivan Bacic, Bernarda
Bakmaz, Nikolina Bratošević Vučičić, Domagoj
Brzic,
Samir Canovic, Emilio Dijan, Maja Grgec
Dragicevic,
Robert Karlo, Suzana Konjevoda, Petra Kovačević,
Ivan
Kovačić, Frane Markulić, Luka Matak, Jakov
Mihanovic,
Domagoj Morović, Gordan Perišić, Andrea Simic,
Neven
Skitarelić, Matea Veršić, Vanja Žufić, Matea Zuzul
(Zadar General Hospital, Zadar); Srdan Ante Anzic,
Iva
Carevic, Dubravka Heli Litvic, Duska Markov-
Glavas,
Tatjana Savic Jovanovic (Children’s Hospital
Srebrnjak,
Zagreb); Goran Augustin, Jerko Biloš, Bojan
Biočina,
Vedrana Biosic, Dino Bobovec, Iva Botica, Boris
Bumber,
Petra Čerina, Ana Danic Hadzibegovic, Katarina
Duric
Vukovic, Hrvoje Gasparovic, Lucija Gatin, Kresimir
Grsic, Ika Gugić Radojković, Ivan Jelčić, Zeljko
Kastelan, Juraj Kolak, Tomislav Kopjar, Tomislav
Kulis,
Kristian Kunjko, Marjan Maric, Marcel Marjanović
Kavanagh, Borna Milicic, Trpimir Morić, Miram
Pasini,
Luka Penezić, Drago Prgomet, Ratko Prstacic,
Andreja
Prtorić, Rudolf Radojković, Ivan Romić, Tomislav
Sečan,
Dora Škrljak Šoša, Juraj Slipac, Mislav Tomic,
Jurica
Zedelj, Toni Zekulić, Zoran Zimak (University
Hospital
Centre Zagreb, Zagreb); Mia Lorencin, Ivica
Luksic,
Matija Mamic (University Hospital Dubrava,
Zagreb).

Hospital Leads:
Croatia: Jakov Mihanovic (Zadar General Hospital,
Zadar)

Local Collaborators:
Croatia: Kristina Bitunjac, Karlo Grulović,
Marijana Vučković (General and Veterans Hospital
‘Hrvatski Ponos’ Knin, Knin); Goran Šantak (County
General Hospital Pozega, Pozega); Emanuel Borovic,
Ana Bosak Versic, Damir Hasandić, Natasa Poldan
Grabar, Suzana Srsen Medancic (University Hospital
Center Rijeka, Rijeka); Lucija Brkic, Sara
Cokarić, Petra Pavic Palac, Zeljka Samac, Josipa
Tomić, Marija Vrdoljak (General Hospital Sibenik,
Sibenik); Ivan Bacic, Bernarda Bakmaz, Nikolina
Bratošević Vučičić, Domagoj Brzic, Samir Canovic,
Emilio Dijan, Maja Grgec Dragicevic, Robert Karlo,
Suzana Konjevoda, Petra Kovačević, Ivan Kovačić,
Frane Markulić, Luka Matak, Jakov Mihanovic,
Domagoj Morović, Gordan Perišić, Andrea Simic,
Neven Skitarelić, Matea Veršić, Vanja Žufić, Matea
Zuzul (Zadar General Hospital, Zadar); Srdan Ante
Anzic, Iva Carevic, Dubravka Heli Litvic, Duska
Markov-Glavas, Tatjana Savic Jovanovic (Children’s
Hospital Srebrnjak, Zagreb); Goran Augustin, Jerko
Biloš, Bojan Biočina, Vedrana Biosic, Dino
Bobovec, Iva Botica, Boris Bumber, Petra Čerina,
Ana Danic Hadzibegovic, Katarina Duric Vukovic,
Hrvoje Gasparovic, Lucija Gatin, Kresimir Grsic,
Ika Gugić Radojković, Ivan Jelčić, Zeljko
Kastelan, Juraj Kolak, Tomislav Kopjar, Tomislav
Kulis, Kristian Kunjko, Marjan Maric, Marcel
Marjanović Kavanagh, Borna Milicic, Trpimir Morić,
Miram Pasini, Luka Penezić, Drago Prgomet, Ratko
Prstacic, Andreja Prtorić, Rudolf Radojković, Ivan
Romić, Tomislav Sečan, Dora Škrljak Šoša, Juraj
Slipac, Mislav Tomic, Jurica Zedelj, Toni Zekulić,
Zoran Zimak (University Hospital Centre Zagreb,
Zagreb); Mia Lorencin, Ivica Luksic, Matija Mamic
(University Hospital Dubrava, Zagreb)

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