Naslov
Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders

Autori
Pivac, Nela ; Vuić, Barbara ; Šagud, Marina ; Nedić Erjavec, Gordana, Nikolac Perković, Matea ; Konjevod, Marcela ; Tudor, Lucija, Švob Štrac, Dubravka ; Uzun, Suzana ; Kozumplik, Oliver ; Uzun, Sandra ; Mimica, Ninoslav

Vrsta, podvrsta i kategorija knjige
Autorske knjige, monografija, znanstvena

Izdavač
Springer

Grad
Singapur

Godina
2023

Stranica
400

ISBN
978-981-19-7375-8

Ključne riječi
Brain-gut axis ; CRP ; Cardiovascular disease ; Chemokines ; Cytokines ; HPA axis ; Immune system ; Inflammation ; Kynurenine pathway ; Oxidative stress ; PTSD

Sažetak
Posttraumatic stress disorder (PTSD) is a severe trauma and stress-related disorder associated with different somatic comorbidities, especially cardiovascular and metabolic disorders, and with chronic low-grade inflammation. Altered balance of the hypothalamic-pituitary-adrenal (HPA) axis, cytokines and chemokines, C-reactive protein, oxidative stress markers, kynurenine pathways, and gut microbiota might be involved in the alterations of certain brain regions regulating fear conditioning and memory processes, that are all altered in PTSD. In addition to the HPA axis, the gut microbiota maintains the balance and interaction of the immune, CNS, and endocrine pathways forming the gut-brain axis. Disbalance in the HPA axis, gut-brain axis, oxidative stress pathways and kynurenine pathways, altered immune signaling and disrupted homeostasis, as well as the association of the PTSD with the inflammation and disrupted cognition support the search for novel strategies for treatment of PTSD. Besides potential anti-inflammatory treatment, dietary interventions or the use of beneficial bacteria, such as probiotics, can potentially improve the composition and the function of the bacterial community in the gut. Therefore, bacterial supplements and controlled dietary changes, with exercise, might have beneficial effects on the psychological and cognitive functions in patients with PTSD. These new treatments should be aimed to attenuate inflammatory processes and consequently to reduce PTSD symptoms but also to improve cognition and reduce cardio-metabolic disorders associated so frequently with PTSD.

Izvorni jezik
Engleski

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