Naslov
Thrombocytopenia induced by immune checkpoint inhibitors in triple negative breast cancer patient – case report

Autori
Linarić, Petra ; Vazdar, Ljubica ; Tečić Vuger, Ana ; Pavlović, Mirjana ; Lepetić, Petra ; Šeparović, Robert

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Libri Oncologici : Croatian Journal of Oncology / - , 2021, 56-57

Skup
1st CROATIAN VIRTUAL CONGRESS OF ONCOLOGY PHARMACY

Mjesto i datum
Online, 07.10.2021. - 10.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
immune thrombocytopenia, TNBC, immune checkpoint inhibitors

Sažetak
Triple negative breast cancer (TNBC) accounts for about 12-17% of all breast cancers. It is a heterogeneous disease that is estrogen receptor (ER) negative, progesterone receptor (PR) negative and human epidermal growth factor receptor 2 (HER2) negative. It has aggressive behaviour and worst prognosis of all breast cancer subtypes, and occurs more often in younger, premenopausal women with higher early recurrence rate and fast progression.It is mainly treated with cytotoxic chemotherapy due to the lack of biomarkers or valid treatment targets.Immune checkpoint inhibitors can induce immune-mediated adverse effects with specific toxicity profile and potential detrimental effects on several organ systems. Although mostly mild and manageable, sometimes severe and even life-threatening adverse effects can occur that require prompt treatment in a hospital setting and discontinuation of immunotherapy, as in the case described by our patient. It is important to know the toxicity profile, as well as early recognition of the immune precipitated adverse effects symptoms and signs in order to start early treatment

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA