Pregled bibliografske jedinice broj: 1262148
Synthesis and biological activity of novel iminocoumarine and acrylonitrile substituted benzazole derivatives
Synthesis and biological activity of novel iminocoumarine and acrylonitrile substituted benzazole derivatives // Conference Book Letter, Third Anatolian Conference on Organic Chemistry (ACOC III)
Antalya, Turska, 2023. str. 89-89 (poster, recenziran, sažetak, znanstveni)
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Naslov
Synthesis and biological activity of novel
iminocoumarine and acrylonitrile substituted
benzazole derivatives
Autori
Hranjec, Marijana ; Boček Pavlinac, Ida ; Beč, Anja ; Persoons, Leentje ; Daelemans, Dirk ; Brajša, Karmen
Kolaboracija
KU Leuven, Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Conference Book Letter, Third Anatolian Conference on Organic Chemistry (ACOC III)
/ - , 2023, 89-89
Skup
Third Anatolian Conference on Organic Chemistry (ACOC III)
Mjesto i datum
Antalya, Turska, 13.03.2023. - 16.03.2023
Vrsta sudjelovanja
Poster
Vrsta recenzije
Recenziran
Ključne riječi
antiproliferative activity, benzazoles, iminocoumarines
Sažetak
Among all known heterocyclic derivatives, nitrogen heterocycles has been widely used in the rational design of novel molecules with improved biological properties.[1] Thus, benzimidazole, benzothizole and imidazo[4, 5-b]pyridine derivatives have been well recognized as one of the most important privileged substructures and structural motifs in medicinal chemistry and pharmaceutical chemistry. [2-3] In this work we have designed and synthesized coumarin and iminocoumarin-benzazole conjugates by using molecular hybridization approach. We have synthesized derivatives with the directly attached benzazole nuclei to the iminocoumarin ring as well as the derivatives with the acrylonitrile bond connecting the coumarin and benzimidazole nuclei. Target compounds were prepared by the cyclocondensation of the corresponding 2- cyanomethylbenzmidazoles, 2-benzothiazole- acetonitrile or 2-cyanomethylimidazo[4, 5- b]pyridine derivatives and corresponding heteroaromatic aldehydes and piperidine in absolute ethanol. All newly prepared coumarin and iminocoumarin-benzazole hybrids were structurally characterized by using 1H and 13C NMR spectroscopy and were evaluated for their antiproliferative activity in vitro on several cancer cells.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija
POVEZANOST RADA
Projekti:
HRZZ-IP-2018-01-4379 - Istraživanje antioksidativnog djelovanja benzazolskog skeleta u dizajnu novih antitumorskih agensa (AntioxPot) (Hranjec, Marijana, HRZZ - 2018-01) ( CroRIS)
Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Fidelta d.o.o.
