Naslov
Dinuclear copper(II) complexes derived from benzopyrone ligand: Synthesis, structural characterization and antiproliferative activity

Autori
Filipović, Nikolina ; Marković, Berislav ; Šarić, Stjepan ; Mišković Špoljarić, Katarina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
28th CROATIAN MEETING OF CHEMISTS & CHEMICAL ENGINEERS / - Rovinj, 2023, 71-71

Skup
28th CROATIAN MEETING OF CHEMISTS & CHEMICAL ENGINEERS

Mjesto i datum
Rovinj, Hrvatska, 28.03.2023. - 31.03.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
benzopyrones, NMR, MTT assay, antiproliferative activity

Sažetak
Benzopyrones belong to a group of six-membered O- heterocyclic compounds that have been intensively studied by scientists in various fields during the last decades. Some of the reasons are easy availability, low toxicity profile and at the same time high functionality. [1] Two new complexes were prepared using copper(II) salts (nitrate and acetate) and chromone2- carboxylic acid (Fig. 1). They were synthesized by the method of classical solution chemistry in a stoichiometric ratio of 1:1 (metal:ligand). The complexes were characterized by FT-IR and NMR spectroscopy, thermal and electrochemical analyses, and their structures are proposed. The results indicate the formation of binuclear Cu(II) complex (1) and hydroxy-bridged binuclear copper(II) complex (2). The cyclic voltammetry showed that copper in both complexes was in the +2 oxidation state. Antiproliferative activity was determined by the MTT test on 2D cell models in vitro on seven human cell lines, one of which was a normal cell line, and the others were tumor cell lines. The test showed that complex (1) has an inhibitory effect on Hep-G2 cells at the highest concentration (10–5 mol dm–3) by 35.2% followed by NCI-H358, MRC-5, HT-29 (54.4% ; 54.7% ; 56.6%) and the complex (2) showed an inhibitory effect on HepG2 cells at the highest concentration (10–5mol dm–3) by 36% followed by NCI-H358, KATO III, HT-29, MRC-5 (59.7% ; 58.3% ; 53.2% ; 51.3%). According to the obtained results of chemical and biological testing, it can be concluded that the chemical route of synthesis was successful. Gained copper(II) complexes are biologically active

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA