Naslov
CAVEOLIN-1 in prostate cancer

Autori
Škara, Lucija ; Abramović, Irena ; Vrhovec, Borna ; Pezelj, Ivan ; Sinčić, Nino ; Tomas, Davor ; Ulamec, Monika

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
HDBMB 2022: book of abstracts / Dulić, Morana ; Sinčić, Nino ; Vrhovac Madunić, Ivana - Zagreb : Hrvatsko Društvo za Biotehnologiju, 2022, 152-152

Skup
Congress of the Croatian Society of Biochemistry and Molecular Biology with international participation

Mjesto i datum
Brela, Hrvatska, 28.09.2022. - 01.10.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Caveolin-1 ; prostate cancer ; biomarkers ; seminal plasma

Sažetak
High prevalence and mortality of prostate cancer (PCa) is well known global health issue. Ongoing search upon new diagnostic, prognostic and predictive marker is always current. There is need of markers which could identify patients with PCa against benign conditions like prostate hyperplasia (BPH) or inflammation. Another issue dealing with indolent PCa course against aggressive forms of the disease is also topic of the intense research. CAV1 is protein whose expression differs among various cancer types and exhibits the dual role of this protein, acting as tumor promoter and tumor suppressor in different tumor settings. We estimated CAV1 could improve PCa diagnostics and aim of this study was to explore CAV1 methylation of cfDNA in liquid biopsy samples, blood and semen, as potential minimally invasive marker. In our study eighty patients with PCa and BPH were analyzed for CAV1 gene expression and methylation in tissue. CAV1 cfDNA methylation from blood and seminal plasma was accessed as potential PCa biomarker. Protein expression of CAV1 in tissue showed changed pattern in the PCa tissue. Methylation in seminal plasma showed potential as biomarker. Discrimination of BPH and Gleason grade group 1 PCa patients from patients with higher Gleason grade groups revealed very good performance as well. Based on our results CAV1 methylation may be useful biomarker with potential for further seminal plasma cfDNA research but its diagnostic accuracy should be improved.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA