Naslov
Suodnos filogenije i ontogenije biofilmova bakterije Bacillus subtilis
(Phylogeny-ontogeny correspondence in Bacillus subtilis biofilms)

Autori
Koska, Sara

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, doktorska disertacija

Fakultet
Prirodoslovno-matematički fakultet

Mjesto
Zagreb

Datum
27.05

Godina
2022

Stranica
85

Mentor
Domazet-Lošo, Tomislav

Ključne riječi
biofilm, Bacillus subtilis, korelacija filogenije i ontogenije, transkriptom, proteom, evolucijska razvojna biologija
(biofilms, Bacillus subtilis, phylogeny-ontogeny correlations, transcriptome, proteome, evo-devo)

Sažetak
Links between ontogeny and phylogeny in animals have been discussed for more than two centuries. With the uprising of molecular biology and bioinformatics, several studies have revealed the presence of the phylogeny-ontogeny correlation on molecular level in developmental transcriptomes of eukaryotic clades with complex multicellularity. These findings open a possibility to test the phylogeny-ontogeny correlation in more basal organisms, with more obscure development and multicellularity characteristics. Using time-resolved transcriptome and proteome profiles, this study showed that Bacillus subtilis biofilm ontogeny correlates with the evolutionary measures through recapitulation pattern, in a way that evolutionary younger and more diverged genes were increasingly expressed towards the later timepoints of the biofilm growth. Molecular and morphological signatures also revealed that biofilm growth is highly regulated and organized into discrete ontogenetic stages. Together, this suggests that the biofilm formation in Bacillus subtilis is a true developmental process comparable to organismal development in animals, plants and fungi.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA