Naslov
Diferencijalna ekspresija gena i evolucijska obilježja morfotipova bakterije Borrelia burgdorferi
(Differential expression and evolutionary signatures of Borrelia burgdorferi morphotypes)

Autori
Čorak, Nina

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, doktorska disertacija

Mjesto
Zagreb

Datum
11.07

Godina
2022

Stranica
162

Mentor
Domazet-Lošo, Tomislav

Ključne riječi
Borrelia burgdorferi ; Lajmska bolest ; diferencijalna ekspresija ; bakterijski morfotipovi ; morfološka plastičnost ; genomska filostratigrafija
(Borrelia burgdorferi ; Lyme disease ; Differential expression ; Bacterial morphotypes ; Morphological plasticity ; Genomic phylostratigraphy)

Sažetak
In laboratory conditions, Borrelia burgdorferi, the causative agent of Lyme disease, exists as a spirochete, round body, bleb, or biofilm culture. This doctoral thesis suggests that spirochete to round body transition relies on the delicate regulation of a relatively small number of evolutionary conserved genes. In contrast, spirochete to bleb and biofilm transition includes significant reshaping of transcription profiles towards evolutionary young genes.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA