Naslov
Metabolomics: a systems approach in studying of cancer biology

Autori
Kulić, Ana ; Penić-Grgaš, Helena ; Sirotković-Skerlev, Maja ; Dedić Plavetić, Natalija ; Pleština, Stjepko ; Sedlić, Filip ; Pašalić, Daria

Izvornik
World Journal of Medical Oncology (2766-6077) 2022 (2022); 1007, 15

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
metabolism ; metabolomics ; cancer ; MS ; NMR

Sažetak
Metabolomics is a systems approach in medical research that aims to quantitatively analyze small molecules (less than 1500 Da) in a given biospecimen. Improvement in analytical technologies enabled metabolic research in various fields of medicine including oncology. Metabolic reprogramming is a firmly established hallmark of cancer. It includes changes in tumor cells and in the stromal cells as well. In this review, we focus on metabolomics in the field of cancer research. In the first part, we discuss the main technical approaches. In the second part, we address altered cancer metabolism and additional roles of some metabolites besides energetic and structural roles.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA