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Pregled bibliografske jedinice broj: 1260827

Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96


Gulić, Tamara; Laskarin, Gordana; Glavan, Lana; Grubić Kezele, Tanja; Haller, Herman; Rukavina, Daniel.
Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96 // International journal of molecular sciences, 24 (2023), 3; 2278-2293 doi:10.3390/ijms24032278 (međunarodna recenzija, članak, znanstveni)


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Naslov
Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96

Autori
Gulić, Tamara ; Laskarin, Gordana ; Glavan, Lana ; Grubić Kezele, Tanja ; Haller, Herman ; Rukavina, Daniel.

Izvornik
International journal of molecular sciences (1422-0067) 24 (2023), 3; 2278-2293

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
decidual dendritic cells ; chemokine ; cytokine ; gp96 ; pregnancy

Sažetak
Heat shock proteins (hsps), in certain circumstances, could shape unique features of decidual dendritic cells (DCs) that play a key role in inducing immunity as well as maintaining tolerance. The aim of the study was to assess the binding of gp96 to Toll-like receptor (TLR) 4 and CD91 receptors on decidual CD1a+ DCs present at the maternal-fetal interface in vitro as well as the influence of CD1a+ DCs maturation status. Immunohistology and immunofluorescence of paraffin-embedded first-trimester decidua tissue sections of normal and pathological (missed abortion MA and blighted ovum BO) pregnancies were performed together with flow cytometry detection of antigens in CD1a+ DCs after gp96 stimulation of decidual mononuclear cells. Gp96 efficiently bound CD91 and TLR4 receptors on decidual CD1a+ DCs in a dose-dependent manner and increased the expression of CD83 and HLA-DR. The highest concentration of gp96 (1000 ng/mL) increased the percentage of Interferon-γ (INF-γ) and IL-15 expressing gp96+ cells. Gp96 binds CD91 and TLR4 on decidual CD1a+ DCs, which causes their maturation and significantly increases INF-γ and IL-15 in the context of Th1 cytokine/chemokine domination, which could support immune response harmful for ongoing pregnancy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka,
Sveučilište u Rijeci

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Gulić, Tamara; Laskarin, Gordana; Glavan, Lana; Grubić Kezele, Tanja; Haller, Herman; Rukavina, Daniel.
Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96 // International journal of molecular sciences, 24 (2023), 3; 2278-2293 doi:10.3390/ijms24032278 (međunarodna recenzija, članak, znanstveni)
Gulić, T., Laskarin, G., Glavan, L., Grubić Kezele, T., Haller, H. & Rukavina, D. (2023) Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96. International journal of molecular sciences, 24 (3), 2278-2293 doi:10.3390/ijms24032278.
@article{article, author = {Guli\'{c}, Tamara and Laskarin, Gordana and Glavan, Lana and Grubi\'{c} Kezele, Tanja and Haller, Herman and Rukavina, Daniel.}, year = {2023}, pages = {2278-2293}, DOI = {10.3390/ijms24032278}, keywords = {decidual dendritic cells, chemokine, cytokine, gp96, pregnancy}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms24032278}, volume = {24}, number = {3}, issn = {1422-0067}, title = {Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96}, keyword = {decidual dendritic cells, chemokine, cytokine, gp96, pregnancy} }
@article{article, author = {Guli\'{c}, Tamara and Laskarin, Gordana and Glavan, Lana and Grubi\'{c} Kezele, Tanja and Haller, Herman and Rukavina, Daniel.}, year = {2023}, pages = {2278-2293}, DOI = {10.3390/ijms24032278}, keywords = {decidual dendritic cells, chemokine, cytokine, gp96, pregnancy}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms24032278}, volume = {24}, number = {3}, issn = {1422-0067}, title = {Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96}, keyword = {decidual dendritic cells, chemokine, cytokine, gp96, pregnancy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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