Pregled bibliografske jedinice broj: 1260556
The effect of mitochondrial energy metabolism modulators on cytotoxicity of cisplatin and pemetrexed in mesothelioma
The effect of mitochondrial energy metabolism modulators on cytotoxicity of cisplatin and pemetrexed in mesothelioma // Virchows Archiv 481 (Suppl 1)
Basel, Švicarska, 2022. str. S144-S144 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1260556 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The effect of mitochondrial energy metabolism
modulators on cytotoxicity of cisplatin and
pemetrexed in mesothelioma
Autori
Sikirić, Sunčana ; Šepac, Ana ; Sedlić, Filip ; Seiwerth, Sven
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Virchows Archiv 481 (Suppl 1)
/ - , 2022, S144-S144
Skup
34th European Congress of Pathology
Mjesto i datum
Basel, Švicarska, 03.09.2022. - 07.09.2022
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
mitochondria ; cytotoxicity ; mesothelioma
Sažetak
The presented results showed that all three tested mitochondrial energy metabolism modulators, UK5099, DNP and DCA, when used in higher concentrations, have a similar pattern of action ; potentiating the cytotoxic effect of cisplatin and pemetrexed. This suggests a synergistic effect of antineoplastic agents and mitochondrial metabolism modulators on reducing mesothelioma cell proliferation. Mitochondrial metabolism modulators have potential for mesothelioma treatment. However, further studies are needed to examine their precise mechanisms of action.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Zagreb
