Naslov
How rare are the rare breast cancers?- A single institution experience

Autori
Cesarec Augustinović, Sanja ; Ramić, Snježana ; Kirigin, Monica Stephany ; Sesar, Patricija ; Puhalo, Ana ; Perić Balja, Melita

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
28th Ljudevit Jurak International Symposium on Comparative Pathology with One Health Session / - Zagreb, 2022, 34-34

Skup
28th Ljudevit Jurak International Symposium on Comparative Pathology with One Health Session

Mjesto i datum
Zagreb, Hrvatska, 10.06.2022. - 11.06.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Breast cancer, Rare breast cancer subtypes, Incidence

Sažetak
As defined by the National Cancer Institute, rare cancer is cancer that occurs in fewer than 15 out of 100, 000 people each year. According to the World Health Organization (WHO) the term “Invasive breast carcinoma” (IBC) refers to a large and heterogeneous group of malignant epithelial neoplasms classified based on histological features. Breast cancers (BC) showing a special histological pattern in more than 90% of the tumor are classified as a pure special tumor type (such as lobular, mucinous and tubular carcinoma). Tumors lacking specific features are designated as invasive ductal carcinoma of no special type (NST). About 75-80% BC are NST while invasive lobular carcinoma, classical type (ILC) comprise 5-15% of BCs. Other (rare) histological types of BC are therefore all other histological types that constitute only about 10% of all BC. Rare subtypes of BC each have unique features but the rarity of many of these neoplasms does not allow large or randomized studies to define the optimal treatment guidelines. Most of the current limited knowledge of these tumors derives from anecdotal case reports or small retrospective studies. From our pathology database we retrieved 5145 BCs diagnosed in 5-year period (2017-2021). The diagnosis for all cases was established according to the criteria of the current WHO classification of breast tumors. Among them 4267 (82.9%) cases were diagnosed as NST and 587 (11.4%) as ILC. There were 291 (5.7%) cases that were diagnosed as other (rare) histological types of BC. Literature indicates that mucinous carcinoma is the main “rare” form of BC, comprising approximately 2% of all primary BC diagnosis. According to our data, there were 106 cases of mucinous carcinoma, comprising 36.4% of rare forms of BC and 2.1% of all BC in our Institution. According to our findings, among total number of BCs, there were diagnosed as follows: 43 (0.8%) cases of carcinomas with apocrine differentiation, 35 (0.7%) cases of micropapillary carcinomas, 29 (0.6%) cases of metaplastic carcinomas, 18 (0.3%) cases of neuroendocrine carcinomas, 21 (0.4%) cases of papillary carcinomas, 15 (0.3%) cases of carcinomas with medullary differentiation, 9 (0.2%) cases of tubular carcinomas, 8 (0.2%) cases of cribriform carcinomas, 3 (0.1%) cases of microinvasive carcinomas, 3 (0.1%) cases of adenoid cystic carcinomas and 1 (0.0%) case of polymorphous adenocarcinoma. The aim was to analyze how really rare are this types of BC in our Institution compared to the incidence indicated in the literature. When compared, data in the literature correspond our findings.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA