Naslov
Physiological and Pharmacological Mechanisms in Gastrointestinal Protection, Ulcer Healing and Mucosal Repair - An Update

Autori
Sikiric, Predrag ; Brzozowski, Tomasz

Izvornik
Current Pharmaceutical Design (1381-6128) 26 (2020), 25; 2933-2935

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
BPC 157 ; cytoprotection ; ulcer healing ; gastrointestinal system

Sažetak
The gastrointestinal tract (GI-tract) is constantly exposed to a variety of strong irritants, toxins, poisoning liquids, drugs and deleterious microbial organisms. Thus, the maintenance of the GI-tract integrity is of great importance for the normal functioning of the physiological processes including proper food intake control, gastrointestinal digestion and absorption. This special issue of Current Pharmaceutical Design was created to provide an update on the crucial mechanisms of GI-tract integrity, protection and ulcer healing of the upper and lower GI-tract, in addition to being enriched with quite recent aspects such as the physiology and pharmacology of brain-gut axis and microbiota. As Guest Editors of this Special Issue, we are truly convinced that despite the extensive and multidisciplinary research presented in these articles, more basic and clinical research is still required for better understanding of the central and peripheral mechanisms of the mucosal protection, as well as repair and healing of the GI-tract mucosa injured by various damaging agents. Future trends in research related to this field of medicine should consider the search for the plethora of molecular regulators, first and second messenger systems for a discussion on novel concepts resulting in better implementation of modes of treatment, and the introduction of a variety of prevention/management modalities with the application of new agents. Therefore, our attempt was to provide an overview of a large frame of pertinent scientific research by eminent experts in the field, providing their most updated experimental and clinical evidence, including the development of new medical products, pro-drugs and new approaches.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA