Pregled bibliografske jedinice broj: 1260215
Stable gastric pentadecapeptide BPC 157 and striated, smooth, and heart muscle
Stable gastric pentadecapeptide BPC 157 and striated, smooth, and heart muscle // Biomedicines, 10 (2022), 12; 3221, 40 doi:10.3390/biomedicines10123221 (međunarodna recenzija, pregledni rad, znanstveni)
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Naslov
Stable gastric pentadecapeptide BPC 157 and striated, smooth, and heart muscle
Autori
Starešinić, Mario ; Japjec, Mladen ; Vraneš, Hrvoje ; Prtorić, Andreja ; Žižek, Helena ; Krezić, Ivan ; Gojković, Slaven ; Smoday, Ivan Maria ; Oroz, Katarina ; Starešinić, Eva ; Dretar, Vilim ; Yago, Haidi ; Milavić, Marija ; Sikirić, Sunčana ; Lovrić, Eva ; Batelja Vuletić, Lovorka ; Simeon, Paris ; Dobrić, Ivan ; Štrbe, Sanja ; Kokot, Antonio ; Vlainić, Josipa ; Boban Blagaić, Alenka ; Škrtić, Anita ; Seiwerth, Sven ; Sikirić, Predrag
Izvornik
Biomedicines (2227-9059) 10
(2022), 12;
3221, 40
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
muscle healing ; stable gastric pentadecapeptide BPC 157 ; therapy
Sažetak
First, we review the definitively severed myotendinous junction and recovery by the cytoprotective stable gastric pentadecapeptide BPC 157 therapy, its healing that might combine both transected and detached tendon and transected muscle, ligament and bone injuries, applied alone, as native peptide therapy, effective in rat injury, given intraperitoneally or in drinking water or topically, at the site of injury. As a follow up, we reviewed that with the BPC 157 therapy, its cytoprotective ability to organize simultaneous healing of different tissues of and full recovery of the myotendinous junction might represent the particular muscle therapy against distinctive etiopathology muscle disabilities and weakness. In this, BPC 157 therapy might recover many of muscle disabilities (i.e., succinylcholine, vascular occlusion, spinal cord compression, stroke, traumatic brain injury, severe electrolyte disturbances, neurotoxins, neuroleptics, alcohol, serotonin syndrome and NO-system blockade and tumor- cachexia). These might provide practical realization of the multimodal muscle-axis impact able to react depending on the condition and the given agent(s) and the symptoms distinctively related to the prime injurious cause symptoms in the wide healing concept, the concept of cytoprotection, in particular. Further, the BPC 157 therapy might be the recovery for the disabled heart functioning, and disabled smooth muscle functioning (various sphincters function recovery). Finally, BPC 157, native and stable in human gastric juice, might be a prototype of anti-ulcer cytoprotective peptide for the muscle therapy with high curing potential (very safe profile (lethal dose not achieved), with suited wide effective range (µg-ng regimens) and ways of application).
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Stomatološki fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Medicinski fakultet, Osijek
Profili:
Ivan Dobrić (autor)
Antonio Kokot (autor)
Mario Starešinić (autor)
Predrag Sikirić (autor)
Slaven Gojković (autor)
Anita Škrtić (autor)
Sanja Štrbe (autor)
Helena Žižek (autor)
Sunčana Sikirić (autor)
Sven Seiwerth (autor)
Lovorka Batelja Vuletić (autor)
Ivan Krezić (autor)
Marija Milavić (autor)
Paris Simeon (autor)
Ivan Maria Smoday (autor)
Alenka Boban Blagaić (autor)
Josipa Vlainić (autor)
Eva Lovrić (autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus