Pregled bibliografske jedinice broj: 1260199
PDGF Modulates BMP2-Induced Osteogenesis in Periosteal Progenitor Cells
PDGF Modulates BMP2-Induced Osteogenesis in Periosteal Progenitor Cells // JBMR Plus, 3 (2019), 5; e10127, 11 doi:10.1002/jbm4.10127 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1260199 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
PDGF Modulates BMP2-Induced Osteogenesis in
Periosteal Progenitor Cells
Autori
Wang, Xi ; Matthews, Brya G ; Yu, Jungeun ; Novak, Sanja ; Grcevic, Danka ; Sanjay, Archana ; Kalajzic, Ivo
Izvornik
JBMR Plus (2473-4039) 3
(2019), 5;
E10127, 11
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
periosteum ; bone morphogenetic protein 2 ; platelet‐derived growth factor ; stem cells ; fracture healing
Sažetak
BMPs are used in various clinical applications to promote bone formation. The limited success of the BMPs in clinical settings and supraphysiological doses required for their effects prompted us to evaluate the influence of other signaling molecules, specifically platelet‐derived growth factor (PDGF) on BMP2‐induced osteogenesis. Periosteal cells make a major contribution to fracture healing. We detected broad expression of PDGF receptor beta (PDGFRβ) within the intact periosteum and healing callus during fracture repair. In vitro, periosteum‐derived progenitor cells were highly responsive to PDGF as demonstrated by increased proliferation and decreased apoptosis. However, PDGF blocked BMP2‐ induced osteogenesis by inhibiting the canonical BMP2/Smad pathway and downstream target gene expression. This effect is mediated via PDGFRβ and involves ERK1/2 MAPK and PI3K/AKT signaling pathways. Therapeutic targeting of the PDGFRβ pathway in periosteum‐mediated bone repair might have profound implications in the treatment of bone disease in the future.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Zagreb