Naslov
Efficacy of lixisenatide in patients with type 2 diabetes: A post hoc analysis of patients with diverse β-cell function in the GetGoal-M and GetGoal-S trials

Autori
Yabe, Daisuke ; Ambos, Anu ; Cariou, Bertrand ; Duvnjak, Lea ; Evans, Marc ; González-Gálvez, Guillermo ; Lin, Jay ; Nikonova, Elena V. ; de Pablos-Velasco, Pedro ; Yale, Jean-François ; Ahrén, Bo

Izvornik
Journal of Diabetes and its Complications (1056-8727) 30 (2016), 7; 1385-1392

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antidiabetic drug ; Beta cell ; GLP-1 analog ; Glycemic control ; Type 2 diabetes

Sažetak
Aims: To evaluate the impact of β-cell function on the efficacy of lixisenatide, a once-daily prandial glucagon-like peptide-1 receptor agonist, in patients with type 2 diabetes (T2D). Materials and methods: In this post hoc analysis, patients from the Phase 3 GetGoal-M and GetGoal-S clinical trials randomized to lixisenatide 20μg once daily were stratified into quartiles by baseline β-cell function, as measured by the secretory units of islet in transplantation (SUIT) index. Results: Patients (N=437) were distributed evenly among SUIT index quartiles 1 to 4 (lowest to highest β-cell function). Clinical outcomes improved from baseline across all SUIT quartiles ; mean changes at week 24 were: glycated hemoglobin (HbA1c ; % [mmol/mol]), -0.99 (-10.8), -0.87 (-9.5), -0.86 (-9.4), -0.83 (-9.1) ; and postprandial plasma glucose (PPG ; mmol/L), -7.9, -5.6, -5.5, -4.3 (overall effect P<0.0001). Furthermore, postprandial glucagon was reduced in all SUIT quartiles, while insulinogenic index improved only in patients with higher baseline SUIT (overall effect P=0.0286). No severe symptomatic hypoglycemic events were reported. Conclusions: Lixisenatide treatment resulted in reductions in HbA1c and PPG levels across all SUIT quartiles. This suggests that non-insulin-related actions of lixisenatide contribute to improved glycemic control in T2D. Trial registration: ClinicalTrials.gov NCT00712673 NCT00713830.

Izvorni jezik
Engleski

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